Comprehensive Evaluation of Corticospinal Tract Metabolites in Amyotrophic Lateral Sclerosis Using Whole-Brain 1H MR Spectroscopy

Changes in the distribution of the proton magnetic resonance spectroscopy (MRS) observed metabolites N-acetyl aspartate (NAA), total-choline (Cho), and total-creatine (Cre) in the entire intracranial corticospinal tract (CST) including the primary motor cortex were evaluated in patients with amyotrophic lateral sclerosis (ALS). The study included 38 sporadic definite-ALS subjects and 70 age-matched control subjects. All received whole-brain MR imaging and spectroscopic imaging scans at 3T and clinical neurological assessments including percentage maximum forced vital capacity (FVC) and upper motor neuron (UMN) function. Differences in each individual metabolite and its ratio distributions were evaluated in the entire intracranial CST and in five segments along the length of the CST (at the levels of precentral gyrus (PCG), centrum semiovale (CS), corona radiata (CR), posterior limb of internal capsule (PLIC) and cerebral peduncle (CP)). Major findings included significantly decreased NAA and increased Cho and Cho/NAA in the entire intracranial CST, with the largest differences for Cho/NAA in all the groups. Significant correlations between Cho/NAA in the entire intracranial CST and the right finger tap rate were noted. Of the ten bilateral CST segments, significantly decreased NAA in 4 segments, increased Cho in 5 segments and increased Cho/NAA in all the segments were found. Significant left versus right CST asymmetries were found only in ALS for Cho/NAA in the CS. Among the significant correlations found between Cho/NAA and the clinical assessments included the left-PCG versus FVC and right finger tap rate, left -CR versus FVC and right finger tap rate, and left PLIC versus FVC and right foot tap rate. These results demonstrate that a significant and bilaterally asymmetric alteration of metabolites occurs along the length of the entire intracranial CST in ALS, and the MRS metrics in the segments correlate with measures of disease severity and UMN function

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

RECHERCHE DE CHLORAMINES DANS L'AIR DES PISCINES COUVERTES ET ENQUETE SUR LA GENE OCCASIONNEE CHEZ LES MAITRES NAGEURS

NANCY1-SCD Pharmacie-Odontologie (543952101) / SudocSudocFranceF

Les légionelloses nosocomiales

NANCY1-SCD Pharmacie-Odontologie (543952101) / SudocNANCY1-Bib. numérique (543959902) / SudocSudocFranceF

Biodégradation de composés organophosphores à liaison P-S (VX, tetriso et demeton-S-methyl)

NANCY1-SCD Pharmacie-Odontologie (543952101) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF

Les mycoses superficielles (diagnostic, traitement, conseils en officine)

NANCY1-SCD Pharmacie-Odontologie (543952101) / SudocSudocFranceF

Le conseil "minceur" en officine, résultats d'une enquête dans les officines de Meurthe-et-Moselle

Le pharmacien d officine, acteur de santé de proximité s engage depuis de nombreuses années dans le conseil minceur . Cependant, cette mission nécessite une formation, du temps et un investissement de l ensemble de l équipe du fait d une demande importante et d un marché en forte croissance. Le pharmacien doit référencer des produits qui ne disposent pas d'une autorisation de mise sur le marché, source de sécurité et d'efficacité. Il doit exercer son sens critique vis à vis de ces demandes et de ces produits, par ailleurs générateurs de chiffre d'affaire. On peut alors se demander si le pharmacien a les compétences nécessaires, de par sa formation, son expérience professionnelle, sa connaissance des clients, pour mener à bien cette mission. Afin de répondre à ces questions une enquête a été conduite auprès des pharmacies de Meurthe et Moselle. L objet de cette enquête est de se rendre compte : de la manière dont les répondants s autoévaluent quant à leurs connaissances dans ce domaine, de leur degré d implication dans la prise en charge du client désirant mincir et de leurs attentes pour pouvoir agir efficacement.NANCY1-SCD Pharmacie-Odontologie (543952101) / SudocSudocFranceF

Formation et stabilité des hydroxysels Fe(II-III) de type rouille verte en cultures bactériennes

NANCY1-SCD Pharmacie-Odontologie (543952101) / SudocSudocFranceF

Cancers cutanés et photoprotection

NANCY1-SCD Pharmacie-Odontologie (543952101) / SudocSudocFranceF