The Rise of Environmental, Social and Corporate Governance Disclosures in the United States and Mandatory Human Rights Due Diligence in Europe: Implications for U.S. Lawyers

Over the past decade, due in part to the devastating impact of the global financial crisis of 2008 and growing awareness of climate change, the world witnessed increasing interest on the part of society in general, and investors in particular, for responsible business. “Responsible business” is the concept that business should be conducted in a way that 1) does not violate fundamental rights of the people affected by the business activity; 2) does not exacerbate environmental harm; and 3) complies with basic principles of good governance. Society’s interest in responsible business has been reflected in growing pressure on businesses to disclose information regarding their impact on the environment and human rights and to take steps to address them. In the United States, given the limited engagement of the legal profession with the UNGP (United Nations Guiding Principles on Business and Human Rights), more needs to be done to educate the legal community on the importance of the UNGP and BHR (Business and Human Rights) more generally. Given their role in either formally regulating the legal profession or providing advocacy and a unified voice as well as enforcing ethical standards, bar associations have a major role to play in educating and mobilizing the legal profession around BHR. At a minimum, bar associations should actively encourage understanding and implementation of the UNGP through conferences, regional initiatives, and training programs. In such cases, it is recommended that bar associations look to engage directly with their members by way of working groups or training programs, in order to encourage a deeper understanding and adherence to the standards established by the UNGP. Given their positions of influence in legal and business communities, bar associations should consider endorsing the UNGP

A formal design synthesis and optimization method for systems architectures

International audienc

Time-varying exponential stabilization of nonholonomic systems in power form

Systems in canonical power form have recently been used to model the kinematic equations of nonholonomic mechanical systems. McCloskey and Murray have had the idea of using the properties of homogeneous systems to derive exponentially stabilizing continuous time-periodic feedbacks for this class of systems. Motivated by this work, the present study extends a control design method previously proposed by Samson to the design of such homogeneous feedbacks. The approach here followed has the advantage of yielding simple and direct stability proofs. Homogeneity-related results needed for time-varying exponential stabilization are also provided

Delayed but Complete Response following Oral Temozolomide Treatment in Melanoma Leptomeningeal Carcinomatosis

Isolated leptomeningeal recurrence of melanoma is rare, occurring in 2% of patients with central nervous system involvement secondary to melanoma. The optimal treatment of leptomeningeal carcinomatosis (LMC) in melanoma has not yet been determined and remains a major challenge. We report a melanoma patient who presented with isolated LMC in the form of a new-onset weakness of the lower limbs, paresthesia of the left hand and foot, lumbago and headache. A lumbar puncture and spinal MRI confirmed LMC. The patient was treated with temozolomide 75 mg/m2/day on a 4 weeks on/2 weeks off schedule. After an initial transient clinical deterioration, the patient showed a complete radiological response as well as a dramatic improvement in quality of life. The encouraging clinical response reported here suggests that dose-intensified temozolomide might have significant activity in the treatment of leptomeningeal dissemination of melanoma and may be a valid treatment option for patients who have not been previously exposed to this agent. Moreover, this treatment regimen is extremely well tolerated and obviates the need for repeated intrathecal administrations of chemotherapeutic agents, which are often not well tolerated by patients who have significant co-morbidities due to their disease. As illustrated in this case, response to temozolomide may occur in a delayed manner, highlighting the importance of following temozolomide treatment long enough before determining that it is inefficient in a given patient

De la ferrure sous le point de vue de l'hygiène, ou de son influence sur la conservation tant des animaux que de leur aptitude au travail : suivi des moyens d'agir sur la corne dans l'intention d'entretenir ou de rétablir les bonnes qualités des pieds des animaux

ER