Buffalo Child Care Means Business: Full Study Report

[Excerpt] Buffalo Child Care Means Business presents the economic and business case for making Buffalo\u27s children the focus of economic development. The 2006 survey of 117 businesses located in downtown Buffalo, New York, documents the business sector\u27s present and projected reliance upon high quality child care services as a necessary component to optimum workplace recruitment, productivity and stability. This promising study highlights research specific to the Buffalo region measuring the cost the community bears as a result of low quality child care and early education. It draws upon nationally recognized economic development strategies to offer recommendations for a strategic child care plan integral to the City of Buffalo\u27s overall strategic initiatives to strengthen downtown\u27s attractiveness to successful enterprises. The early development needs of Buffalo\u27s children must be front and center if the potential economic power of broadly successful education is to be realized. With business, government, education and child care leaders at the table, Buffalo\u27s economic renaissance can be built on individual and social foundations that last a lifetime

Lesson plans to stimulate beginning creative writing in grades three, four, and five

Thesis (Ed.M.)--Boston Universit

Investigation of slow collisions for (quasi) symmetric heavy systems: what can be extracted from high resolution X-ray spectra

We present a new experiment on (quasi) symmetric collision systems at low-velocity, namely Ar$^{17+}$ ions ($v=0.53$ a.u.) on gaseous Ar and N$_2$ targets, using low- and high-resolution X-ray spectroscopy. Thanks to an accurate efficiency calibration of the spectrometers, we extract absolute X-ray emission cross sections combining low-resolution X-ray spectroscopy and a complete determination of the ion beam - gas jet target overlap. Values with improved uncertainty are found in agreement with previous results \cite{Tawara2001}. Resolving the whole He-like Ar$^{16+}$ Lyman series from $n=2$ to 10 with our crystal spectrometer enables to determine precisely the distribution ${\mathcal{P}_n}$ of the electron capture probability and the preferential $n_{pref}$ level of the selective single-electron capture. Evaluation of cross sections for this process as well as for the contribution of multiple-capture is carried out. Their sensitivity to the $\ell$-distribution of $n$ levels populated by single-electron capture is clearly demonstrated, providing a stringent benchmark for theories. In addition, the hardness ratio is extracted and the influence of the decay of the metastable $1s2s\ ^3 S_1$ state on this ratio is discussed

Y27632, a Rho-activated kinase inhibitor, normalizes dysregulation in alpha1-adrenergic receptor-induced contraction of Lyon hypertensive rat artery smooth muscle.

RhoA-activated kinase (ROK) is involved in the disorders of smooth muscle contraction found in hypertension model animals and patients. We examined whether the alpha1-adrenergic receptor agonist-induced ROK signal is perturbed in resistance small mesentery artery (SMA) of Lyon genetically hypertensive (LH) rats, using a ROK antagonist, Y27632. Smooth muscle strips of SMA and aorta were isolated from LH and Lyon normotensive (LN) rats. After Ca(2+)-depletion and pre-treatment with phenylephrine (PE), smooth muscle contraction was induced by serial additions of CaCl(2). In LH SMA Ca(2+) permeated cells to a lesser extent as compared with LN SMA, while CaCl(2)-induced contraction of LH SMA was greater than that of LN SMA, indicating a higher ratio of force to Ca(2+) in LH SMA contraction (Ca(2+) sensitization). No hyper-contraction was observed in LH aorta tissues. Treatment of LH SMA with Y27632 restored both Ca(2+) permeability and Ca(2+)-force relationship to levels seen for LN SMA. In response to PE stimulation, phosphorylation of CPI-17, a phosphorylation-dependent myosin phosphatase inhibitor protein, and MYPT1 at Thr853, the inhibitory phosphorylation site of the myosin phosphatase regulatory subunit, was increased in LN SMA, but remained unchanged in LH SMA. These results suggest that the disorder in ROK-dependent Ca(2+) permeability and Ca(2+)-force relationship is responsible for LH SMA hyper-contraction. Unlike other hypertensive models, the ROK-induced hyper-contractility of LH SMA is independent of MYPT1 and CPI-17 phosphorylation, which suggests that ROK-mediated inhibition of myosin phosphatase does not affect SMA hyper-contractility in LH SMA cells

Investigation of human bocavirus associated with acute respiratory infection in patients treated in health unit in Guarapuava – PR / Investigação de bocavírus humano associado à infecção respiratória aguda em pacientes atendidos em unidade de sáude do Município de Guarapuava - PR

Human Bocavirus (HBoV) is a parvovirus in human respiratory secretions isolates from symptomatic patients. Its prevalence varies from 1.5 to 19% and the most common age for a primary infection is between 6 to 24 months age. HBoV has been associated with infections in the upper and lower children respiratory tract, little is known about HBoV infections among adults and the elderly. The present study objective was to investigate the HBoV occurrence in children and adults with acute respiratory symptoms. One hundred and eighty-theree nasal swab samples from symptomatic patients that are attended in the public health services in Guarapuava city, in Paraná State between 2014 and 2015. The patients´ mean age included in the essay was 35 years old and the 33 years median, varying from less than 1 year and up to 82 years age. The most commonly observed symptoms were coryza, cough and fever. The samples were tested for HBoV DNA presence by standard PCR methodology. No positive samples were detected for HBoV. Thus, we did not demonstrate the HBoV circulation in Guarapuava - PR, but more studies are necessary, taking into account that these new viruses may be important pathogens in respiratory diseases in Brazil

The Iowa Homemaker vol.12, no.9

Mayonnaise or Turtle Soup… By Jean B. Guthrie, ‘31 This Little Pig Went to Market… By Margaret Stover Diet to Be Fat or to Be Thin… By Ella Gertrude McMullen Cutting the Cost of College… By Regina Kilde

Is it possible to discriminate odors with common words ?

Several experiments have been performed in order to study the cognitive processes which are involved in odor recognition. The current report summarizes experimental protocol and analyzes collected data. The goal is to try to recognize odors from descriptors which are selected by subjects from a list. Different groups have to choose in several descriptor lists, some with profound descriptors and some with a few surface descriptors. Profound descriptors are supposed to involved more cognition than surface descriptors. Subjects also have to name the odors. Recorded data are first analyzed, and then learned by an incremental neural classifier. The problem is hard to be learned. It seems very difficult to discriminate the different odors from the sets of descriptors. A variant of the learning algorithm, less sensitive to difficult examples, is proposed. The pertinence of surface descriptors is discussed.Des expériences ont été réalisées pour étudier les processus cognitifs impliqués dans la reconnaissance des odeurs. Ce rapport résume le protocole expérimental et étudie les données collectées. Le but est d'essayer de discriminer des odeurs à partir de descripteurs qui sont choisis par les sujets dans une liste. Plusieurs groupes travaillent avec différentes listes de descripteurs, ces descripteurs pouvant être de surface ou profonds. Les descripteurs profonds sont supposés être imliqués dans des traitememts plus cognitifs que les descripteurs de surface. Les sujets doivent également nommer les odeurs. Les données recueillies sont d'abord analysées, puis apprises par un classifieur neuronal incrémental. Le problème est difficile à apprendre. Il semble très délicat de discriminer les odeurs à partir des jeux de descripteurs. Une variante de l'algorithme d'apprentissage, moins sensible aux exemples difficiles, est proposée. La pertinence des descripteurs de surface est discutée

Resistenzausprägung von hetero- und homozygot resistenten Genotypen eines Acker-Fuchsschwanz-Biotypen mit Target-Site Resistenz (Haplotyp Leu1781) in Dosis-Wirkungsversuchen mit Clethodim und Cycloxydim

Anhand von Dosis-Wirkungsversuchen und molekularbiologischen Analysen wurde die Reaktion der Gesamtpopulation eines Biotyps von Acker-Fuchsschwanz (Alopecurus myosuroides) mit Target-Site Resistenz gegen ACCase-Inhibitoren (Ile1781-Leu) auf die Wirkstoffe Clethodim und Cycloxydim mit der Reaktion der homozygoten (reinerbigen) und der heterozygoten (mischerbigen) Teilpopulation verglichen. Um die beobachtete Reaktion in die einer homo- und heterozygoten Teilpopulation aufzuschlüsseln, wurden individuelle Pflanzen bezüglich des Haplotyps Leu1781 mittels SNP-Analytik (Pyrosequencing) differenziert. Für die Gesamtpopulation ergaben sich signifikant unterschiedliche Resistenzfaktoren (RF) von 8 für Clethodim und 153 für Cycloxydim. Nach Korrelation der Phäno- und Genotypen ergab sich für die heterozygote Teilpopulation ein RF von 6 für Clethodim und 118 für Cycloxydim und für die homozygote Teilpopulation ein RF von 10 für Clethodim und 136 für Cycloxydim. Obwohl sich die RF der homo- und heterozygoten Teilpopulationen nicht signifikant unterschieden, zeigten die geringeren RF der heterozygoten Teilpopulationen den deutlichen Trend einer verringerten Resistenzausprägung. Lässt sich dieser Trend in weiteren Versuchen bestätigen, so kann angenommen werden, dass die Selektion von Resistenz in einer Feld-Population neben dem eingesetzten Wirkstoff auch von der Frequenz der Genotypen abhängig ist. Die beobachteten Unterschiede zwischen der Reaktion von Acker-Fuchsschwanz mit dem Haplotyp Leu1781 auf die Wirkstoffe Clethodim und Cycloxydim verdeutlichen zudem die Bedeutung der stets individuell zu betrachtenden Konstellation von Resistenzmechanismus, Genotyp und Wirkstoff für die Selektion und Ausbreitung von Resistenz. Stichwörter: Alopecurus myosuroides, Dosis-Wirkungsversuche, Pyrosequenzierung, Target-Site Resistenz Degree of resistance of hetero- and homozygous resistant genotypes of a target-site resistant blackgrass biotype (haplotype Leu1781) in dose-response experiments with clethodim and cycloxydim Abstract In dose-response experiments and by molecular analyses the reaction of a black grass biotype (Alopecurus myosuroides) with target site resistance to ACCase inhibitors (Ile1781-Leu) was examined for the response to clethodim and cycloxydim and compared to the responses of the homozygous and heterozygous sub-populations. To decipher the population into the homo- and heterozygous sub-populations, individual plants of the resistant biotype were analyzed for the haplotype Leu1781 by means of SNP analytics (pyrosequencing). For the entire population, significant different resistance factors (RF) of 8 and 153 resulted for clethodim and cycloxydim, respectively. For the heterozygous sub-population a RF of 6 was estimated for clethodim and 118 for cycloxydim. For the homozygous sub-population a RF of 10 for clethodim and 136 for cycloxydim was estimated. The RF between the homo- and heterozygous sub-populations for each herbicide were, however, not significantly different. Despite this, a tendency of the heterozygous sub-population being less resistant was indicated. Therefore, it is hypothesized that the selection of resistance depends not only on the herbicide used, but on the frequency of the genotypes in a field population. Furthermore, the significant different reaction of black grass with the haplotype 1781 to both tested herbicides reflects the meaning of the individual constellation of active ingredient, resistance mechanisms and genotype for selection and spread of resistance. Keywords: Alopecurus myosuroides, dose-response, pyrosequencing, target-site resistanc