Interview with Jean Orr Belcher

https://digitalcommons.winthrop.edu/scmotheroftheyear/1025/thumbnail.jp

Comparison of ten packages that compute ocean carbonate chemistry

International audienceMarine scientists often use two measured or modeled carbonate system variables to compute others. These carbonate chemistry calculations, based on well-known thermodynamic equilibria, are now available in a dozen public packages. Ten of those were compared using common input data and the set of equilibrium constants recommended for best practices. Current versions of all 10 packages agree within 0.2 μatm for pCO2, 0.0002 units for pH, and 0.1 μmol kg−1 for CO32− in terms of surface zonal-mean values. That represents more than a 10-fold improvement relative to outdated versions of the same packages. Differences between packages grow with depth for some computed variables but remain small. Discrepancies derive largely from differences in equilibrium constants. Analysis of the sensitivity of each computed variable to changes in each constant reveals the general dominance of K1 and K2 but also the comparable sensitivity to KB for the AT–CT input pair. Best-practice formulations for K1 and K2 are implemented consistently among packages. Yet with more recent formulations designed to cover a wider range of salinity, packages disagree by up to 8 μatm in pCO2, 0.006 units in pH, and 1 μmol kg−1 in CO32− under typical surface conditions. They use different proposed sets of coefficients for these formulations, all of which are inconsistent. Users would do well to use up-to-date versions of packages and the constants recommended for best practices

The management of the abortion-prone patient

Abstract Not Provided

Thromboxane A2 receptor (TBXA2R) is a potent survival factor for triple negative breast cancers (TNBCs)

Triple Negative Breast Cancer (TNBC) is defined by the lack of ERα, PR expression and HER2 overexpression and is the breast cancer subtype with the poorest clinical outcomes. Our aim was to identify genes driving TNBC proliferation and/or survival which could represent novel therapeutic targets. We performed microarray profiling of primary TNBCs and generated differential genelists based on clinical outcomes following the chemotherapy regimen FEC (5-Fluorouracil/Epirubicin/Cyclophosphamide -‘good’ outcome no relapse > 3 years; ‘poor’ outcome relapse < 3 years). Elevated expression of thromboxane A2 receptor (TBXA2R) was observed in ‘good’ outcome TNBCs. TBXA2R expression was higher specifically in TNBC cell lines and TBXA2R knockdowns consistently showed dramatic cell killing in TNBC cells. TBXA2R mRNA and promoter activities were up-regulated following BRCA1 knockdown, with c-Myc being required for BRCA1-mediated transcriptional repression. We demonstrated that TBXA2R enhanced TNBC cell migration, invasion and activated Rho signalling, phenotypes which could be reversed using Rho-associated Kinase (ROCK) inhibitors. TBXA2R also protected TNBC cells from DNA damage by negatively regulating reactive oxygen species levels. In summary, TBXA2R is a novel breast cancer-associated gene required for the survival and migratory behaviour of a subset of TNBCs and could provide opportunities to develop novel, more effective treatments

ICSM CHC White Paper II: Impacts, vulnerability, and understanding risks of climate change for culture and heritage: Contribution of Impacts Group II to the International CoSponsored Meeting on Culture, Heritage and Climate Change

Climate change is already impacting multiple types of heritage across all regions of the world. Future climate change poses increased risks to heritage globally, including losses and damages to heritage of current and future generations and particularly severe impacts on the intangible cultural heritage of Indigenous communities. Climate change impacts on heritage are not being studied consistently nor systematically, which is reflected in heritage coverage in IPCC assessments and special reports. There is a global imbalance in the number of publications assessing the impact of climate change on heritage between different regions. Regional, national and sub-national disparities are also observed (example of Australia East vs. West). As a result, it is difficult to know if what we know about the impact of climate change on heritage is just a reflection of where the science is funded rather than where or when heritage is being affected by climate change. Impacts of climate change on the broader economic benefits (besides tourism), and social and cultural value of heritage are neither investigated nor reviewed globally and rarely explored regionally or locally. Disparities in climate change / heritage publications appear to be determined by research funding, income inequality (within and between countries), colonial legacy (research ties and relationships between former colonies and colonising countries), legal systems of heritage protection (imbalance between natural and cultural heritage depending on the country/region), local vs. international interest in heritage, the language of publication (focus on English excluding other significant scientific languages such as French, Spanish, or Japanese). Improvement of data reliability and resolution allows for more nuanced reconstructions of impacts of past climatic events, facilitating historically important factors of societal adaptation processes proportional to those changes. Yet they do not provide straightforward solutions for contemporary anthropogenic climate change as the scale of recent changes across the climate system are unprecedented over many centuries to many thousands of years. Alignment of climate change risk terms may facilitate collaboration between climate science and heritage research fields and enhance the likelihood of uptake by large climate change assessments like the IPCC. Innovative methods, especially those which are ideal for assessing social and cultural vulnerability, are needed to integrate the value of intangible cultural heritage with assessments of climate change risk. There is opportunity for climate change / heritage research to embrace transformational, inter- and transdisciplinary, and decolonial principles to address a range of the research and practice challenges as the field matures

Surgical treatment for different forms of hernias in sheep and goats

Sheep and goats are frequently presented with different forms of hernias to veterinary clinics. The aim of this study is to investigate the outcome of the surgical treatment of abdominal, umbilical, inguinal and scrotal hernias in sheep and goats. Fifty-eight clinical cases (sheep = 44, goat = 14) were presented to the Veterinary Teaching Hospital, College of Agriculture and Veterinary Medicine, Qassim University, Saudi Arabia from September, 2003 to September, 2006. These animals had abdominal (sheep = 30, goat = 10), umbilical (sheep = 6, goat = 4), inguinal (sheep = 7) and scrotal (sheep = 1) hernias. All the cases of hernias in sheep and goats were subjected to full study including the history of the case, classification of hernias, the size of the hernial ring, surgical repair of the hernias, adhesions between the hernial sacs in each case, the postoperative care and follow up of the cases. The results revealed that gender had an effect on the incidence of hernia. The incidence of abdominal hernias was higher in females and the incidence of inguinal hernia was higher in males. There was a positive correlation between the history of hernia and the degree of adhesion. For the sheep, 26 out of 30 cases of abdominal hernia had good outcomes and the healing was excellent. There were postoperative complications in 4 ewes. For the goats, there were slight swellings at the site of operation in 2 out of 10 cases of abdominal hernia, while the remaining 8 cases had good outcomes. There was one case of umbilical hernia with an umbilical abscess that had broken down with sepsis formation at the surgical site. In conclusion, the success rates of surgical treatment for all types of hernias were very high and there were no significant differences in the success rates among the different types of hernias in both sheep and goats. The types of suture materials and the types of hernias had no significant effect on the outcome of the surgical treatment

Ocean Acidification: Summary for Policymakers

Third Symposium on the Ocean in a High-CO2 Worl

Ozeanversauerung: Zusammenfassung für Entscheidungsträger

Third Symposium on the Ocean in a High-CO2 Worl