764 research outputs found

    Introducing a Framework to Capture and Reuse Tacit Knowledge in Software Project Management

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    In rapidly growing global companies, comprehensive training programs as well as in depth sharing of knowledge are essential factors to maintain the quality of human capital despite rapid expansion. Different dimensions of Knowledge management address the need and approach to leverage dispersed knowledge in order to make it visible and accessible for everyone to improve organizational performance. However, there has been a scarcity of successful and holistic models that define and categorize tacit knowledge in order to capture and distribute it for the benefit of others. This paper focuses on developing a framework in order to capture experiences regarding software project management and to provide a platform for managers to inherit knowledge from and bequeath their learning to others at large organizations. In order to build up and enhance the framework, the majority of information was gleaned from intensive interviews with top software project managers at Infosys, a well-known global company in the field of software development and consulting services. The final framework we developed can act as a comprehensive data-repository for capturing, storing, searching, and distributing tacit knowledge of project managers

    Physico-chemical fingerprinting of RNA genes

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    We advance here a novel concept for characterizing different classes of RNA genes on the basis of physico-chemical properties of DNA sequences. As knowledge-based approaches could yield unsatisfactory outcomes due to limitations of training on available experimental data sets, alternative approaches that utilize properties intrinsic to DNA are needed to supplement training based methods and to eventually provide molecular insights into genome organization. Based on a comprehensive series of molecular dynamics simulations of Ascona B-DNA consortium, we extracted hydrogen bonding, stacking and solvation energies of all combinations of DNA sequences at the dinucleotide level and calculated these properties for different types of RNA genes. Considering ∼7.3 million mRNA, 255 524 tRNA, 40 649 rRNA (different subunits) and 5250 miRNA, 3747 snRNA, gene sequences from 9282 complete genome chromosomes of all prokaryotes and eukaryotes available at NCBI, we observed that physico-chemical properties of different functional units on genomic DNA differ in their signatures

    The HI content of star-forming galaxies at z = 0.24

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    We use observations from the Giant Metrewave Radio Telescope (GMRT) to measure the atomic hydrogen gas content of star-forming galaxies at z = 0.24 (i.e. a look-backtime of ~3 Gyr). The sample of galaxies studied were selected from Halpha-emitting field galaxies detected in a narrow-band imaging survey with the Subaru Telescope. The Anglo-Australian Telescope was used to obtain precise optical redshifts for these galaxies. We then coadded the HI 21 cm emission signal for all the galaxies within the GMRT spectral line data cube. From the coadded signal of 121 galaxies, we measure an average atomic hydrogen gas mass of (2.26 +- 0.90)*10^9 solar masses. We translate this HI signal into a cosmic density of neutral gas at z = 0.24 of Omega_gas = (0.91 +- 0.42)*10^-3. This is the current highest redshift at which Omega_gas has been constrained from 21 cm emission and our value is consistent with that estimated from damped Lyman-alpha systems around this redshift. We also find that the correlations between the Halpha luminosity and the radio continuum luminosity and between the star formation rate and the HI gas content in star-forming galaxies at z = 0.24 are consistent with the correlations found at z = 0. These two results suggest that the star formation mechanisms in field galaxies ~3 Gyr ago were not substantially different from the present, even though the star formation rate is 3 times higher.Comment: 11 pages, contains 9 figures and 1 table. Accepted for publishing in MNRAS 2007 January 22. Received 2007 January 22; in original form 2006 November 3

    Fuzzy Implications: Some Recently Solved Problems

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    In this chapter we discuss some open problems related to fuzzy implications, which have either been completely solved or those for which partial answers are known. In fact, this chapter also contains the answer for one of the open problems, which is hitherto unpublished. The recently solved problems are so chosen to reflect the importance of the problem or the significance of the solution. Finally, some other problems that still remain unsolved are stated for quick reference

    Planar 17O NMR study of Pr_yY_{1-y}Ba_2Cu_3O_{6+x}

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    We report the planar ^{17}O NMR shift in Pr substituted YBa_{2}Cu_{3}O_{6+x}, which at x=1 exhibits a characteristic pseudogap temperature dependence, confirming that Pr reduces the concentration of mobile holes in the CuO_{2} planes. Our estimate of the rate of this counterdoping effect, obtained by comparison with the shift in pure samples with reduced oxygen content, is found insufficient to explain the observed reduction of T_c. From the temperature dependent magnetic broadening of the ^{17}O NMR we conclude that the Pr moment and the local magnetic defect induced in the CuO_2 planes produce a long range spin polarization in the planes, which is likely associated with the extra reduction of T_c. We find a qualitatively different behaviour in the oxygen depleted Pr_yY_{1-y}Ba_2Cu_3O_{6.6}, i.e. the suppression of Tc_c is nearly the same, but the magnetic broadening of the ^{17}O NMR appears weaker. This difference may signal a weaker coupling of the Pr to the planes in the underdoped compound, which might be linked with the larger Pr to CuO_2 plane distance, and correspondingly weaker hybridization.Comment: 8 pages, 9 figures, accepted in Phys Rev

    Effective interaction between helical bio-molecules

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    The effective interaction between two parallel strands of helical bio-molecules, such as deoxyribose nucleic acids (DNA), is calculated using computer simulations of the "primitive" model of electrolytes. In particular we study a simple model for B-DNA incorporating explicitly its charge pattern as a double-helix structure. The effective force and the effective torque exerted onto the molecules depend on the central distance and on the relative orientation. The contributions of nonlinear screening by monovalent counterions to these forces and torques are analyzed and calculated for different salt concentrations. As a result, we find that the sign of the force depends sensitively on the relative orientation. For intermolecular distances smaller than 6A˚6\AA it can be both attractive and repulsive. Furthermore we report a nonmonotonic behaviour of the effective force for increasing salt concentration. Both features cannot be described within linear screening theories. For large distances, on the other hand, the results agree with linear screening theories provided the charge of the bio-molecules is suitably renormalized.Comment: 18 pages, 18 figures included in text, 100 bibliog

    Adsorption of mono- and multivalent cat- and anions on DNA molecules

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    Adsorption of monovalent and multivalent cat- and anions on a deoxyribose nucleic acid (DNA) molecule from a salt solution is investigated by computer simulation. The ions are modelled as charged hard spheres, the DNA molecule as a point charge pattern following the double-helical phosphate strands. The geometrical shape of the DNA molecules is modelled on different levels ranging from a simple cylindrical shape to structured models which include the major and minor grooves between the phosphate strands. The densities of the ions adsorbed on the phosphate strands, in the major and in the minor grooves are calculated. First, we find that the adsorption pattern on the DNA surface depends strongly on its geometrical shape: counterions adsorb preferentially along the phosphate strands for a cylindrical model shape, but in the minor groove for a geometrically structured model. Second, we find that an addition of monovalent salt ions results in an increase of the charge density in the minor groove while the total charge density of ions adsorbed in the major groove stays unchanged. The adsorbed ion densities are highly structured along the minor groove while they are almost smeared along the major groove. Furthermore, for a fixed amount of added salt, the major groove cationic charge is independent on the counterion valency. For increasing salt concentration the major groove is neutralized while the total charge adsorbed in the minor groove is constant. DNA overcharging is detected for multivalent salt. Simulations for a larger ion radii, which mimic the effect of the ion hydration, indicate an increased adsorbtion of cations in the major groove.Comment: 34 pages with 14 figure

    Effect of anisotropic impurity scattering in superconductors

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    We discuss the weak-coupling BCS theory of a superconductor with the impurities, accounting for their anisotropic momentum-dependent potential. The impurity scattering process is considered in the t-matrix approximation and its influence on the superconducting critical temperature is studied in the Born and unitary limit for a d- and (d+s)-wave superconductors. We observe a significant dependence of the pair-breaking strength on the symmetry of the scattering potential and classify the impurity potentials according to their ability to alter T_c. A good agreement with the experimental data for Zn doping and oxygen irradiation in the overdoped cuprates is found.Comment: 31 pages, RevTex, 15 PostScript figure

    Attraction between DNA molecules mediated by multivalent ions

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    The effective force between two parallel DNA molecules is calculated as a function of their mutual separation for different valencies of counter- and salt ions and different salt concentrations. Computer simulations of the primitive model are used and the shape of the DNA molecules is accurately modelled using different geometrical shapes. We find that multivalent ions induce a significant attraction between the DNA molecules whose strength can be tuned by the averaged valency of the ions. The physical origin of the attraction is traced back either to electrostatics or to entropic contributions. For multivalent counter- and monovalent salt ions, we find a salt-induced stabilization effect: the force is first attractive but gets repulsive for increasing salt concentration. Furthermore, we show that the multivalent-ion-induced attraction does not necessarily correlate with DNA overcharging.Comment: 51 pages and 13 figure
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