A rare incidence of averting ‘maternal near-miss’ in a case of spontaneous uterine rupture in shock

Uterine rupture is a rare but catastrophic obstetric emergency associated with significant feto-maternal morbidity and mortality. There are various risk factors and wide spectrum of clinical presentations have been identified; previous cesarean delivery being most common risk factor. Spontaneous rupture of unscarred uterus is infrequently encountered, but very dangerous for both mother and fetus as remotely suspected. Usually, spontaneous rupture of primigravida uterus is considered almost immune as it is rare but not unheard of; it may occur before or after onset of labour, at term or preterm and with or without fetal heart rate abnormality. The reported case was such a case of spontaneous unscarred uterine rupture with favourable outcome for both mother and baby

Sinteza i antimikrobno djelovanje derivata oksazolinona i imidazolinona

A few imidazolinones [1-aminoethyl/phenyl-2-methyl/phenyl-4-acetylidene/benzylidene-imidazolin-5(4H)-ones] were newly synthesized from respetive acetylidene/benzylidene oxazolinones. Schiff\u27s bases were synthesized by the reaction between imidazolinones and benzaldehyde. The antimicrobial screening of almost all compounds showed moderate to significant activities against B. subtilis ATCC 6633 and K. pneumoniae ATCC 25063. Compounds 10 [1-aminophenyl-2-phenyl-4-acetylidene-imidazolin-5(4H)-one] and 12 [1-aminophenyl-2-phenyl-4-benzylidene-imidazolin-5(4H)-one] showed even better activity than amphotericin B against C. albicans ATCC 29738.Sintetizirano je nekoliko novih derivata imidazolinona 1-aminoetil/fenil-2-metil/fenil-4-acetiliden/benziliden-imidazolin-5(4H)-ona iz odgovarajućeg acetiliden/benziliden oksazolinona. Reakcijom imidazolinona i benzaldehida pripravljene su Schiffove baze. Skoro svi spojevi posjeduju umjereno antimikrobno djelovanje na B. subtilis ATCC 6633 i K. pneumoniae ATCC 25063. Spojevi 10 1-aminofenil-2-fenil-4-acetiliden-imidazolin-5(4H)-on i 12 1-aminofenil-2-fenil-4-benziliden-imidazolin-5(4H)-on su čak aktivniji od amfotericina B na gljivicu C. albicans ATCC 29738

Studies on in vitro antiplasmodial activity of cleome rutidosperma

Malaria is a protozoal disease transmitted by the Anopheles mosquito, caused by minute parasitic protozoa of the genus Plasmodium, which infect human and insect hosts alternatively. It affects over 40% of the worldís population, with 120 million cases reported, and about 2 million deaths annually (1). The P. falciparum variety of the parasite accounts for 80% of cases and 90% of deaths caused by malaria. The declining efficacy of classical medication in relation to the rapid increase of parasite resistant strains, mainly of Plasmodium falciparum, as well as the greater resistance of vectors to insecticides, and the difficulty of creating efficient vaccines have led to an urgent need for new efficient antimalarial drugs (2, 3). Natural molecules may provide innovative strategies towards malarial control, hence active research groups are now working to develop new active compounds as an alternative to chloroquine, especially from artemisinin (4, 5), a plant-based antimalaria drug isolated from the Chinese plant Artemisia annua (6). Plants may well, therefore, prove to be the sources of new antimalarial in view of the success with the two important chemotherapeutic agents, quinine and artemisinin, both of which are derived from plants. Cleome rutidosperma (Capparidaceae) is a low-growing herb, up to 70 cm tall, found in waste grounds and grassy places with trifoliate leaves and small, violet-blue flowers, which turn pink as they age. The elongated capsules display the asymmetrical, dull black seeds. The plant is native to West Africa, although it has become naturalized in various parts of tropical America as well as Southeast Asia (7, 8). The diuretic, laxative, anthelmintic, antimicrobial, analgesic, anti-inflammatory, antipyretic, antioxidant and free radical scavenging activities of Cleome rutidosperma were reported earlier by the authors (9-13). The plant is used as antimalarial by the traditional healers in Cameroon and mild antiplasmodial activity of chloroform/methanol (1:1) extract of leaves of Cleome rutidosperma against chloroquine-sensitive (F32) laboratory strain of P. falciparum was reported earlier in Cameroon (14). The present study investigates the in vitro antiplasmodial activity of ethanolic extract and its fractions of aerial parts of Cleome rutidosperma against the chloroquine sensitive (CQS) D10 strain of the parasite, as well as their toxicity against a mammalian cell lines

IDENTIFICATION AND MAPPING OF TECTONICALLY ACTIVE POTENTIAL ZONES IN NORTHEASTERN PART OF ARAVALLI MOUNTAIN RANGE

The Great Boundary Fault (GBF) forms the eastern margin of the Aravalli Mountain Range (AMR) and, is exposed as boundary between highly deformed rocks of the AMR and relatively undeformed Vindhyan rocks. The GBF acts as important active dislocation zone between Himalayan regime in the north and, Son-Narmada regime in the south. Nevertheless, the intensity of active tectonics along GBF is relatively mild and hence, it requires special technique to identify and map active tectonics zone along this thrust. The thematic maps of geology, geomorphology, slope, and vegetation index of study area have been prepared using Landsat 7 ETM + digital data. These themes are integrated in GIS environment to assess the active tectonic potential in the area. The observed four high potential zones in the area are located at the intersection of NE-SW lineaments. The study brings out methodology for assessing active tectonic potential of the area. 1