Sinteza i antimikrobno djelovanje derivata oksazolinona i imidazolinona

Abstract

A few imidazolinones [1-aminoethyl/phenyl-2-methyl/phenyl-4-acetylidene/benzylidene-imidazolin-5(4H)-ones] were newly synthesized from respetive acetylidene/benzylidene oxazolinones. Schiff\u27s bases were synthesized by the reaction between imidazolinones and benzaldehyde. The antimicrobial screening of almost all compounds showed moderate to significant activities against B. subtilis ATCC 6633 and K. pneumoniae ATCC 25063. Compounds 10 [1-aminophenyl-2-phenyl-4-acetylidene-imidazolin-5(4H)-one] and 12 [1-aminophenyl-2-phenyl-4-benzylidene-imidazolin-5(4H)-one] showed even better activity than amphotericin B against C. albicans ATCC 29738.Sintetizirano je nekoliko novih derivata imidazolinona 1-aminoetil/fenil-2-metil/fenil-4-acetiliden/benziliden-imidazolin-5(4H)-ona iz odgovarajućeg acetiliden/benziliden oksazolinona. Reakcijom imidazolinona i benzaldehida pripravljene su Schiffove baze. Skoro svi spojevi posjeduju umjereno antimikrobno djelovanje na B. subtilis ATCC 6633 i K. pneumoniae ATCC 25063. Spojevi 10 1-aminofenil-2-fenil-4-acetiliden-imidazolin-5(4H)-on i 12 1-aminofenil-2-fenil-4-benziliden-imidazolin-5(4H)-on su čak aktivniji od amfotericina B na gljivicu C. albicans ATCC 29738

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