New concept for a regenerative and resorbable prosthesis for tendon and ligament. Physicochemical and biological characterization of PLA-braided biomaterial

We present a concept for a new regenerative and resorbable prosthesis for tendon and ligament and characterize the physicomechanical and biological behavior of one of its components, a hollow braid made of poly-lactide acid (PLA) which is the load-bearing part of the prosthesis concept. The prosthesis consists of a braid, microparticles in its interior serving as cell carriers, and a surface non-adherent coating, all these parts being made of biodegradable materials. The PLA braid has a nonlinear convex stress-strain behavior with a Young modulus of 1370 +/- 90 MPa in the linear, stretched state, and after 12 months of hydrolytic degradation the modulus shows a reduction by a factor of four. Different disinfection methods were tested as to their efficiency in cleansing the braid and preparing it for cell culture. Fibroblasts of L929 line were grown on the PLA braid for 14 days, showing good adherence and proliferation. These studies validate the PLA braid for the intended purpose in the regenerative prosthesis concept. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 101A: 3228-3237, 2013This work has been developed thanks to the financial support of AITEX (Valencia, Spain). JME thanks Drs. Isabel Pascual, Andres Pena, and their team from Hospital Clinico of Valencia for their fine work.Araque Monrós, MC.; Gamboa Martinez, TC.; Gil Santos, L.; Gironés Bernabé, S.; Monleón Pradas, M.; Más Estellés, J. (2013). New concept for a regenerative and resorbable prosthesis for tendon and ligament. Physicochemical and biological characterization of PLA-braided biomaterial. Journal of Biomedical Materials Research Part A. 101A(11):3228-3237. doi:10.1002/jbm.a.34633S32283237101A11Vieira, A. C., Guedes, R. M., & Marques, A. T. (2009). Development of ligament tissue biodegradable devices: A review. Journal of Biomechanics, 42(15), 2421-2430. doi:10.1016/j.jbiomech.2009.07.019Kuo, C. K., Marturano, J. 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Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

Immunogenetics and cellular immunology of bacterial infectious disease

Personal Career with Poverty Problem Solving of Entrepreneur in DusitArea

AbstractThis research aimed to find problems and attitude of people who wereself-employed. The questionnaire survey and structured interview were used to collect data. There were 200 participants who were street vendors in Dusit Districtparticipated in this study. The results found that majority of the respondents were female, middle aged, and used to work as employees in private business sectors before. Average circulation per day was not over 5000 baht, with average 1,000 bath margin. The reasons to be self-employed were to earn income faster and free of being controlled. Problems of being self-employed were: no good location to sell things, no wholesale sources, no financial support from state agencies. Self-employment can be improved by providing support as stated

Evaluation of hip arthroscopy using a hip-specific distractor for the treatment of femoroacetabular impingement.

Background and study aimsHip arthroscopy using an orthopaedic traction table has been associated with traction-related neurovascular complications. Since the use of a hip-specific distractor for performing hip arthroscopy hasn't been associated with those specific complications we hypothesized that a hip-specific distractor might facilitate the learning curve of hip arthroscopy for beginner surgeons.Material and methodsWe reviewed retrospectively the first 56 hip arthroscopies performed to treat femoro-acetabular impingement using a hip-specific distractor. We tried to analyse the learning curve of this procedure using operative time, peri- and postoperative complications, hospital stay and patient satisfaction. We also evaluated pre- and postoperative sports activities and tried to identify some factors as poor postoperative prognostic factors.ResultsOnly 1 major complication occurred. No traction-related complications have been encountered. The curves analysing intervention time and postoperative satisfaction rate showed improvement after 30 cases performed. In all cases, we were able to perform the whole planned gesture without difficulties accessing the hip joint.ConclusionThe hip-specific distractor is a safe and reproducible method in performing hip arthroscopy without any traction-related complications or time limits

Arthroplastie totale de hanche par mini abord: revue de la littérature et expérience de la voie antérieure directe sur table orthopédique.

In addition to the choice of the surgical approach, the respective place of the mini-incisions and mini-invasive surgery for total hip arthroplasty (THA) remains a controversial topic. The purpose of this study was to specify the advantages and disadvantages of these different approaches by a systematic review of the orthopedic literature and by our experience of the first 100 THA implanted by mini-invasive direct anterior approach (DAA) on orthopedic table. Selecting 15 orthopedic journals, we found 252 articles among which 65 are particularly relevant; 25 correspond to randomized studies. Mini-invasive approaches permit to obtain results at least equivalent to standard approaches with regard to operative time, general complications and adequate component positioning. Contrarily to posterior approach, DAA is associated to a low dislocation rate, even in so-called "at risks patients". Recent randomized studies highlight an earlier functional recovery in patients treated by mini-invasive approaches and particularly by DAA. This advantage seems to persist only the first six weeks but it could be interesting to patients avid to resume quickly their activities. Nevertheless, further studies are mandatory to confirm the observed results and to specify the place of the mini-invasive approaches with regard to early recovery as long-term results.English AbstractJournal ArticleReviewSCOPUS: re.jinfo:eu-repo/semantics/publishe

A low dislocation rate after revision total hip arthroplasty performed through the anterior approach

Background: Dislocation is a major complication in revision total hip arthroplasties. This study aimed to evaluate the dislocation rate, complications, and functional scores of revision total hip arthroplasty performed through the direct anterior approach. Methods: Between January 2014 and March 2020, 84 patients undergoing revision total hip arthroplasty were retrospectively reviewed. All operations were performed through the direct anterior approach. At the final follow-up, incidences of dislocation, reoperation, acute deep infections, periprosthetic fractures and psoas impingement were assessed. The median postoperative Oxford Hip Score was also calculated. Results: At revision surgery, the mean age was 66 ± 12 years (range, 28–91). During an average follow-up of 4.2 ± 1.2 years, reoperation rate for major complications in the non-infected revisions was 15% (n = 11), including five acute deep infections (7%), four periprosthetic fractures (5%), one dislocation and one psoas impingement (1%). The median postoperative Oxford Hip Score was 39 (interquartile range = 14). Conclusion: In our series, revision total hip arthroplasty through direct anterior approach was associated with a very low dislocation rate, acceptable complication rates and good functional results. Our results suggest that this procedure is safe and reliable. Trial registration: Ethical approval for this study was obtained, before enrollment of the first participant, by CUB Erasme's research ethics committee (P2020/323) and C.H.U Ambroise Paré's research ethics committee.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Aseptic Loosening after Total Hip Arthroplasty in an Acromegalic Patient: A Case Report.

Acromegaly is a rare disorder characterized by excess secretion of growth hormone and its principle mediator, insulin-like growth factor-1. Although acromegaly is frequently associated with osteoarthritis, the outcome of arthroplasty in this population is not documented.info:eu-repo/semantics/publishe

A 'made in one piece' skeleton in a 22-year-old man suffering from sickle cell anaemia.

A 22-year-old African male with known sickle cell anaemia was referred by a Congolese medical centre with a request to improve his poor physical condition. He was unable to walk, stand or sit because his large joints and his spine were either ankylosed or very rigid. Radiographs showed joint fusion from the third to the fifth cervical vertebrae, of both hips, of the left knee, and a bilateral osteonecrosis of the humeral head. There was no scintigraphic evidence for an active osteomyelitis (99mTc-MDP (methyldiphosphonate) bone scan, Tc monoclonal antigranulocyte scan and 99mTc sulphur colloid scan). To improve his mobility the right femoral head was resected in June 1997; 14 days later the left femoral head was resected. Four months after the resection of the right hip, a right uncemented total hip prosthesis was implanted on this side. One month later the same type of hip arthroplasty was performed on the left side. During the postoperative rehabilitation period the patient regained autonomy. We have found no previous reports of such severe and multiple joint complications in a single patient suffering from sickle cell anaemia.Case ReportsJournal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Traitement des fractures complexes de l'humérus proximal par enclouage verrouillé (Telegraph). Résultats d'une étude prospective préliminaire.

Treatment of complex fractures of the proximal humerus is still controversial. This prospective study was designed to evaluate the results of open reduction and proximal nailing in complex fractures of the proximal humerus. Fifteen patients aged 39 to 83 years (average: 59 years) presenting severely displaced fractures of the proximal humerus were observed after open reduction and fixation by proximal nailing (Telegraph) combined with screwing and/or osteosuture of the tuberosities. The patients were evaluated at one year clinically and radiologically. The Constant score, DASH score and Simple Shoulder Test were calculated. Complementarily, patients were submitted to an isokinetic test. At one year follow-up, the average range of motion was 85 degrees (40 degrees-170 degrees) for elevation, 82 degrees (40 degrees-170 degrees) for abduction, L3 for internal rotation and 34 degrees (10-60 degrees) for external rotation. The average visual analog score was 3 points (0-8 points). The Constant score varied from 17 to 92 points (average: 48 points). Isokinetic evaluation showed mostly a strength deficit in abduction even for patients presenting an excellent result. Functional results were related to the quality of the surgical reduction but also to patients' collaboration. Various treatment methods for complex fracture of the proximal humerus are reported in the literature. When a nearly anatomical reduction is achieved, the here-described method of open reduction and proximal nailing permits to obtain good functional results in most patients. This option should be considered for young patients and even in the elderly where results are comparable to that obtained with hemiarthroplasty in the same condition.English AbstractJournal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe