Tribal Corridor Management Planning: Model, Case Study, and Guide for Caltrans District 1, Research Report 10-01

In Northern California, tribal governments and personnel of the California Department of Transportation (Caltrans) District 1, have applied innovative context-sensitive solutions to meet a variety of transportation challenges along state highways that traverse tribal lands. This report describes and discusses the efforts under way and offer suggestions for continuing and extending these initiatives through the development of Tribal Corridor Management Plans (TCMPs). The methods employed in this project are multidisciplinary and include: (1) content analysis of existing corridor management plans; (2) literature review to identify “best practices;” (3) participant observation; (4) interviews with local stakeholders; (5) focus group interviews with Caltrans personnel; and (6) landscape analysis. This study’s authors conclude that Caltrans District 1 staff and tribal governments share common goals for highway operations; however, progress —while significant—has been somewhat hampered by geographic and administrative challenges. It is recommended that Caltrans and the tribes seek early and frequent communication and collaboration to overcome these obstacles. Further, they identify several examples of non-standard design elements that could be incorporated into highway improvements to enhance local sense of place among both residents and travelers. A preliminary TCMP for the segment of State Route 96 that lies within the boundaries of the Hoopa Valley Indian Reservation is presented as an example. Beyond its role as a guide for initiating tribal corridor projects within Caltrans District 1, the report should prove instructive for any efforts to enhance sense of place within transportation byways, particularly in Native communities

Urban Education Reform- Case Study: North Forest Independent School District

Education reformers and advocates have conducted extensive studies and produced significant research around various models of school turnaround and reform. As a case study for policy in relation to models for school district turnaround, we will explore Houston’s North Forest Independent School District (NFISD). The purpose of this paper is threefold. First, as a study of policy we will retroactively explore the key factors that led to the proposed closure of NFISD. Second, using existing strategies of school turnaround, we will explore potential models of reform that may be applied to NFISD. Third, we will discuss biases and recommendations concerning a proposed annexation of NFISD by the Houston Independent School District (HISD) and how those biases and recommendations could potentially influence policy and ultimately increase student achievement

The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease.

Perivascular microglia activation is a hallmark of inflammatory demyelination in multiple sclerosis (MS), but the mechanisms underlying microglia activation and specific strategies to attenuate their activation remain elusive. Here, we identify fibrinogen as a novel regulator of microglia activation and show that targeting of the interaction of fibrinogen with the microglia integrin receptor Mac-1 (alpha(M)beta(2), CD11b/CD18) is sufficient to suppress experimental autoimmune encephalomyelitis in mice that retain full coagulation function. We show that fibrinogen, which is deposited perivascularly in MS plaques, signals through Mac-1 and induces the differentiation of microglia to phagocytes via activation of Akt and Rho. Genetic disruption of fibrinogen-Mac-1 interaction in fibrinogen-gamma(390-396A) knock-in mice or pharmacologically impeding fibrinogen-Mac-1 interaction through intranasal delivery of a fibrinogen-derived inhibitory peptide (gamma(377-395)) attenuates microglia activation and suppresses relapsing paralysis. Because blocking fibrinogen-Mac-1 interactions affects the proinflammatory but not the procoagulant properties of fibrinogen, targeting the gamma(377-395) fibrinogen epitope could represent a potential therapeutic strategy for MS and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation

Natural Salinity Removal Processes in Reservoirs

A small but significant amount of salinity removal has been reported by various authors to occur in mainstem Colorado River reservoirs. Recalculation of some of these salinity budgets, together with a review of the data bases used, usggests taht removal has not often been conclusively demonstrated. Laboratory microcosm experiments and field data indicate that calcium carbonate precipitation, perhaps with some coprecipitation of magnesium carbonate, is the mechanism responsible for most of the salinity removal in Oneida Reservoir, Idaho. Coprecipitation processes (including ion exchange), coagulation, and bioassimilation do not appear to be important natural salinity removal mechanisms. Finally, loss of calcium, relative to monovalent cations, may decrease water quality for irrigation purposes through increasing the sodium adsorption ratio (SAR), despite a pross decrease in the TDS. The potential role of various reservoir operation options in managing natural salinity removal processes and the value of such removal is discussed