26 research outputs found
Protective effect of L-ornithine-L-aspartate and silymarin on chemically induced kidney toxicity and thyroid dysfunction in mice
The present study was designed to reveal the hitherto unknown efficacy of two commonly
used hepatoprotective drugs, L-ornithine-L-aspartate (lornit) and silymarin in the regulation of
kidney toxicity and thyroid dysfunction in mice. Renal and hepatic lipid peroxidation (LPO)
was induced by the administration of carbon tetrachloride (CCl4) for 2 weeks (2.0 gm/kg
twice a week). In two separate groups, along with CCl4 animals were also treated with either
lornit (200 mg/kg) or silymarin (100 mg/kg) every day for the same duration. Other than hepatic
and renal LPO, alterations in the concentrations of serum triiodothyronine (T3), thyroxine
(T4), glucose and insulin and in hepatic type-1 iodothyronine 5’monodeiodinase (5’DI)
activity were considered as major parameters. Simultaneously activities of serum aspartate
aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphahatase (ALP) and
hepatic and renal superoxide dismutase (SOD), catalase (CAT) and reduced glutathione content
(GSH) were also studied. Lornit or silymarin administration reversed almost all the toxic
effects exhibited by CCl4 including enhanced tissue LPO, serum ALT, AST and ALP activities
and the concentrations of insulin and glucose. Both test drugs also significantly increased
hepatic 5’DI activity, cellular antioxidants such as SOD, CAT and GSH and serum levels of
both the thyroid hormones
Modified Ratio and Product Estimators for Population Mean in Systematic Sampling
The estimation of population mean in systematic sampling is explored. Properties of a ratio and product estimator that have been suggested in systematic sampling are investigated, along with the properties of double sampling. Following Swain (1964), the cost aspect is also discussed
Assessing Safety Against Floods for an Ashpond Garlanded by Two Natural Streams
Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv
Fuzzy FMEA model: a case study to identify rejection and losses in fibre industry
The growing competition between fibre producing industry and the standards to which, it requires high quality standards. ABC company’s procurement department data shows N of number of defects in cellulose pulp sheet uncurl every month. Cellulose sheet is an important raw material in the fibre (Staple) producing industry. Quality tools such as Failure Mode and Effects Analysis (FMEA) applied to admeasure the risk of potential miscarriages. This study aims to determine the most dominant activity as the cause of rejection and losses of cellulose sheets and evince improvements that can be made by using the fuzzy FMEA model. Data collection techniques in the study are using the method of observations, interviews as well as assessment of experts to identity it. This study is based on the four criterion which dominates the defect of cellulose pulp sheet vis. Processing activities, acceptance, examination and delivery. Solicitation for overcoming these problems is presented
Effect of metformin on renal microsomal proteins, lipid peroxidation and antioxidant status in dexamethasone-induced type-2 diabetic mice
44-48An SDS-PAGE analysis of renal microsomal fraction of albino mice was performed to study the involvement of proteins in dexamethasone-induced type-2 diabetes mellitus (DM) and their alterations by metformin, a widely accepted oral antidiabetic drug. In addition, changes in renal lipid peroxidation (LPO), activities of superoxide dismutase (SOD) and catalase (CAT), reduced glutathione (GSH) content, as well as renal somatic index (RSI) and daily rate of water consumption were also investigated. While dexamethasone administration (1.0 mg/kg for 21 days) expressed two renal proteins (43 kDa and 63.23 kDa), in addition to the increased fasting serum levels of glucose and insulin, renal LPO, RSI and daily rate of water consumption, a parallel decrease in renal SOD, CAT and GSH was also observed. Treatment with metformin normalized these alterations including the renal proteins and LPO, confirming its efficacy in ameliorating dexamethasone-induced type-2 DM and also the association of two proteins with type-2 DM
Dipeptidyl peptidase IV (DPP-IV/CD26) inhibitory and free radical scavenging potential of W. somnifera and T. foenum-graecum extract
The incretin hormone glucagon-like peptide 1 (GLP-1), proposed as a new target for the treatment of type 2 diabetes, is rapidly cleaved by dipeptidyl peptidase-IV enzyme (DPP-IV/CD26). DPP-IV inhibitors enhance circulating GLP-1 level, which in turn resulted into improved glucose tolerance and insulin secretion. The present study was designed to evaluate DPP-IV inhibitory activities vis a vis anti-peroxidative potential, if any, in two antidiabetic plants. We studied in vitro DPP-IV inhibition; DPPH radical scavenging potential; ß-carotene bleaching; reducing power and total phenolics content at the varying concentrations (0.1 – 1 mg/ml) in the extracts of W. somnifera (WS) root and T. foenum-graecum (TFG) seeds. Methanolic extract (0.5 mg/ml) of WS inhibited DPP-IV activities (69.7 ±0.56%) at greater extent than that of TFG (51.8±1.24%), as compared to control. WS extract contains relatively higher amount of total phenolics, elevated DPPH free radical scavenging potential and pronounced reducing power efficacy than that of TFG. The result of present study ravel that WS and TFG extracts contain some novel DPP-IV inhibitors with antiperoxidative potential and could be developed as therapeutic molecules for type 2 diabetes mellitus
A Ratio-Cum-Product Estimator of Finite Population Mean in Systematic Sampling
In this paper we consider the problem of estimation of population mean using information on two auxiliary variables in systematic sampling. We have extended Singh (1967) estimator for estimation of population mean in systematic sampling. We have derived the expressions for the bias and mean squared error of the suggested estimator up to the first degree of approximation. We have compared the suggested estimator with existing estimators and obtained the conditions under which the suggested estimator is more efficient. An empirical study has been carried out to demonstrate the performance of the suggested estimator
CYTOPROTECTIVE AND DIPEPTIDYL PEPTIDASE IV (DPP-IV/CD26) INHIBITORY ROLES OF OCIMUM SANCTUM AND MOMORDICA CHARANTIA EXTRACT
Objective- The present work deals with investigation of DPP-IV inhibition activity vis a vis cytoprotective potential, if any, in two ant-diabetic plants in methanolic extracts of Ocimum sanctum (Tulsi) leaves and. Momordica charantia (Karela/ bitter melon) fruit.Methods- The DPP-IV activity and cytoprotective were studied based on different antioxidant activity assays such as  hepatic lipid per- oxidation, erythrocytes haemolysis inhibition, in vitro DPP-IV activity; DPPH radical scavenging efficacy; ferric reducing potential; reducing power and total phenolic contents at the varying concentrations in the extracts of O.sanctum  and M.charantia.Result- Methanolic extract (0.5 mg/ml) of OS inhibited DPP-IV activities (66.81±0.05percent) at greater extent than that of M. charantia (53.25±0.04percent); O .sanctum extract contains relatively higher amount of total phenolic content, elevated DPPH free radical scavenging potential and pronounced reducing power efficacy than that of M. charantia. O .sanctum inhibited erythrocytes haemolysis at greater extent (13.1±0.188 µg/ml) as compared to M. charantia (10.3±0.41 µg/ml).Conclusion- The result of present study ravel that O .sanctum and M. charantia extracts contain some novel DPP-IV inhibitors with antiperoxidative potential and could be developed as therapeutic molecules for type 2 diabetes mellitus.Key words: Ant-diabetic plants; Antioxidant; DPP-IV inhibitors; In vitro; Type 2 diabetes mellitu