Wybór środków dydaktycznych w procesie kształtowania wrażliwości muzycznej pianisty

The process of gaining pianist abilities by students depends a great deal on personal and music qualities of their teachers. The author of the article proves that it is the teacher’s attitude that decides on whether music is likely to become the student’s subject of self-realization and his/her further life aims. She outlines and discusses the basic assumptions of didactics and the teaching process, such as teaching principles, forms of work, methods considered to be indispensable in the process of shaping the music sensitivity and their influence on sound quality, playing technique, interpretation of a music work and its general artistic form

The differential effects of neuroleptic drugs and PACAP on the expression of BDNF mRNA and protein in a human glioblastoma cell line

It has been suggested that, in addition to modulation of monoaminergic neurotransmission, antipsychotic drugs can also affect expression of neurotrophic factors in the brain. The present study was aimed to examine the effects of the first generation neuroleptic drug (FGA; haloperidol) and second generation neuroleptic drugs (SGAs; olanzapine and amisulpride) on expression and level of brain-derived neurotrophic factor (BDNF) in astrocyte-like T98G glioblastoma cell line. Effects of these drugs were compared to the action of PACAP38, a neuropeptide with well known BDNF-mediated neuroprotective effects. The tested neuroleptics differentially regulated the mRNA expression and protein level of BDNF depending on the concentration and incubation time. Using rtPCR technique, we demonstrate that, from the three tested neuroleptics, both haloperidol as well as olanzapine at 5 μM concentration (but not at 20 μM) increased BDNF mRNA expression with a similar efficacy after a 72 h incubation. In order to confirm the observed changes in the mRNA expression of BDNF, a protein expression assay was performed. The exposure of cells only to 5 μM olanzapine for 72 h increased BDNF concentration in the culture medium by 29%. Additionally, PACAP significantly up-regulated BDNF mRNA expression in T98G cells and the obtained results correlated positively with the increased production of BDNF protein, by 22% above control. The results of the paper show that olanzapine, similarly to exogenous PACAP38, increased BDNF mRNA expression and protein release, which can contribute to its neuroprotective mechanism of action in the cells of nonneuronal origin. The results of the present paper confirm the findings that BDNF may represent the key target for olanzapine and PACAP

Concomitant Administration of Different Doses of Simvastatin with Ivabradine Influence on PAI-1 and Heart Rate in Normo- and Hypercholesterolaemic Rats

Ivabradine is a novel heart rate lowering agent that inhibits If ionic current in the sinus node and demonstrates antiischaemic and antianginal activity. The aim of the paper was to investigate the effect its dose-dependent drug-drug interaction with simvastatin inhibitor HMGCo-A has on PAI-1 blood level, heart rate and blood pressure. The experiments were performed in hyper- and normocholesterolemic Wistar rats receiving simvastatin (1 and 20 mg × kg−1 bw) with ivabradine (10 mg × kg−1 bw) during a 4-week period. Ivabradine exacerbated the decrease of PAI-1 in normocholesterolemic animals receiving simvastatin at a dose of 1 mg/kg bw and was not observed to have any significant influence on the PAI-1 values in rats receiving 20 mg × kg−1 bw simvastatin. Ivabradine, coadministered with simvastatin given at a dose of 20 mg × kg−1 bw, significantly slowed the heart rate in normocholesterolaemic and hypercholesterolaemic groups as compared to the group receiving ivabradine alone. Conclusion. The administration of ivabradine to normocholesterolaemic and hypercholesterolaemic rats receiving simvastatin significantly exacerbated the slowing of heart rate with no effect on blood pressure. The administration of ivabradine has been shown to demonstrate different effects on PAI-1 values depending on lipid disorders

Flow Structure, Drop Deformation and Mass Transfer in Dense Emulsions

This paper presents applications of a new model of the rheological behaviour of dense oil-inwater emulsions of non-colloidal droplets to describe the flow structure, the effects of the flow of dense emulsion on drop deformation and the related increase of the interfacial area and the mass transfer rate

Flow Structure, Drop Deformation and Mass Transfer in Dense Emulsions

This paper presents applications of a new model of the rheological behaviour of dense oil-inwater emulsions of non-colloidal droplets to describe the flow structure, the effects of the flow of dense emulsion on drop deformation and the related increase of the interfacial area and the mass transfer rate

Rosuvastatin, sildenafil and their combination in monocrotaline-induced pulmonary hypertension in rat

There is considerable interest in the pleiotropic effects of statins and their potential role in the treatment of pulmonary hypertension. Previous experimental findings indicate that a combination of lipophilic statins with phosphodiesterase type-5 inhibitor, sildenafil, can offer preventive effects on rat monocrotaline-induced pulmonary hypertension. The present study is aimed to assess whether therapeutic regimen provides any benefits. Seven days after pulmonary hypertension induction, hydrophilic rosuvastatin and sildenafil were given 14 days to male Wistar outbred rats. Right ventricular pressure, right ventricle mass and three biomarkers were evaluated after 21 days: brain natriuretic peptide, high-density lipoprotein cholesterol and vascular endothelial growth factor. The present study demonstrates that administration of hydrophilic statin with sildenafil results in reduction of pulmonary vascular remodeling and right ventricular pressure. The results of biochemical measurements may suggest that statins play a positive role in right ventricle function or the process of angiogenesis in pulmonary hypertension development

Dental and oral manifestations of coeliac disease - a literature review

Introduction  Coeliac disease is a genetic autoimmune disease of the digestive system. It is caused by permanent intolerance to gluten (a protein contained in wheat, rye, barley), which results in the atrophy of the intestinal villi in the small intestine and deficiency of nutrients in the body. It can also manifest itself with various pathologies within the teeth and oral mucosa.  Aim of the study  The purpose of the study is to present the symptoms of coeliac disease in oral cavity.  Materials and methods PubMed and Google Scholar medical databases were analyzed, operating with the following keywords: coeliac disease, oral cavity, manifestations, lesions, symptoms, oral health in as many configurations as needed. Twenty-eight related articles published during the last five years (2018-2023) were selected.  Results  In addition to the classic intestinal symptomatology, coeliac disease can also manifest itself in the oral cavity in the form of delayed tooth eruption, enamel defects, MIH, recurrent aphthous stomatitis or xerostomia. The etiology of the changes is still not clear, but studies show that they most likely arise as a result of impaired absorption of vitamins and minerals in the small intestine.  Conclusion The variety of symptoms of celiac disease makes it a significant diagnostic challenge. It is important to raise awareness among dentists about the symptoms of the disease because a quick diagnosis can prevent many complications.   &nbsp