Knight Innovation Awards: An Interview with Honoree Neil deGrasse Tyson

Jeff Jarvis (Tow-Knight Center for Entrepreneurial Journalism at CUNY Graduate School of Journalism) and Dr. Tyson explore the universe -- and have a lot of fun doing it -- in this in-depth and wide-ranging interview. This video was recorded on October 14, 2015 during the Knight Innovation Awards at the CUNY Graduate School of Journalism

News Accuracy in Switzerland and Italy

Nearly 80 years of accuracy research in the United States has documented that the press frequently errs, but empirical study about news accuracy elsewhere in the world is absent. This article presents an accuracy audit of Swiss and Italian daily regional newspapers. Replicating US research, the study offers a trans-Atlantic perspective of news accuracy. To compare newspaper accuracy in Switzerland and Italy to longitudinal accuracy research in the United States, the study followed closely the methodology pioneered by Charnley (1936) and adapted by Maier (2005). News sources found factual inaccuracy in 60 percent of Swiss newspaper stories they reviewed, compared to 48 percent of US and 52 percent of Italian newspapers examined. The results show that newspaper inaccuracy—and its corrosive effect on media credibility—transcends national borders and journalism cultures. Nowadays, digitization offers new ways of implementing correction policies. Media organizations need, however, to adapt to these changes and to adapt their structures in particular to new forms of participative and interactive two-way communication

Herschel-ATLAS: Blazars in the science demonstration phase field

To investigate the poorly constrained sub-mm counts and spectral properties of blazars we searched for these in the Herschel-ATLAS (H-ATLAS) science demonstration phase (SDP) survey catalog. We cross-matched 500 μm sources brighter than 50 mJy with the FIRST radio catalogue. We found two blazars, both previously known. Our study is among the first blind blazar searches at sub-mm wavelengths, i.e., in the spectral regime where little is still known about the blazar SEDs, but where the synchrotron peak of the most luminous blazars is expected to occur. Our early results are consistent with educated extrapolations of lower frequency counts and question indications of substantial spectral curvature downwardsand of spectral upturns at mm wavelengths. One of the two blazars is identified with a Fermi/LAT Υ-ray source and a WMAP source. The physical parameters of the two blazars are briefly discussed. These observations demonstrate that the H-ATLAS survey will provide key information aboutthe physics of blazars and their contribution to sub-mm counts.We are grateful to the referee, P. Padovani, for very useful comments. Thanks are due to the PACO collaboration for having made available the data on the 2 blazars. M.M. and L.B. thanks the staff at the Australia Telescope Compact Array site, Narrabri (NSW), for the valuable support they provide in running the telescope. Work partially supported by the Italian Space Agency (contract I/016/07/0 "COFIS'' and ASI/INAF Agreement I/072/09/0 for the Planck LFI Activity of Phase E2). This research has made use of the NASA/IPAC Extragalactic Database (NED) which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration

A dynamic Bayesian network for identifying protein-binding footprints from single molecule-based sequencing data

Motivation: A global map of transcription factor binding sites (TFBSs) is critical to understanding gene regulation and genome function. DNaseI digestion of chromatin coupled with massively parallel sequencing (digital genomic footprinting) enables the identification of protein-binding footprints with high resolution on a genome-wide scale. However, accurately inferring the locations of these footprints remains a challenging computational problem

Aptamer-based multiplexed proteomic technology for biomarker discovery

Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes (15 [mu]L of serum or plasma). Our current assay allows us to measure ~800 proteins with very low limits of detection (1 pM average), 7 logs of overall dynamic range, and 5% average coefficient of variation. This technology is enabled by a new generation of aptamers that contain chemically modified nucleotides, which greatly expand the physicochemical diversity of the large randomized nucleic acid libraries from which the aptamers are selected. Proteins in complex matrices such as plasma are measured with a process that transforms a signature of protein concentrations into a corresponding DNA aptamer concentration signature, which is then quantified with a DNA microarray. In essence, our assay takes advantage of the dual nature of aptamers as both folded binding entities with defined shapes and unique sequences recognizable by specific hybridization probes. To demonstrate the utility of our proteomics biomarker discovery technology, we applied it to a clinical study of chronic kidney disease (CKD). We identified two well known CKD biomarkers as well as an additional 58 potential CKD biomarkers. These results demonstrate the potential utility of our technology to discover unique protein signatures characteristic of various disease states. More generally, we describe a versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations. This unbiased and highly multiplexed search engine will enable the discovery of novel biomarkers in a manner that is unencumbered by our incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine

Do Online, Offline, and Multiplatform Journalists Differ in their Professional Principles and Practices? Findings from a Multinational Study

Online journalists are often believed, not least in the industry itself, to follow different professional standards from their print and broadcast colleagues. There is, however, little empirical evidence to support or to refute this perception. This paper intends to help fill that gap by investigating whether offline and online journalists differ in their professional principles and practices. Drawing on previous conceptual research by Deuze, we operationalize the concept of journalism as an ideology comprising four ideal professional values: public service, objectivity, autonomy, and ethics. Using survey data from the Worlds of Journalism Study we compare professional principles and practices among online, offline, and multiplatform journalists in nine Western and Eastern European countries (N = 6,089). We find, contrary to previous research, that principles and practices among online and offline journalists broadly conform. However, we also find that online journalists are more likely than their offline colleagues to find justification for publishing unverified information and less interested in holding politicians to account, despite reporting that they have more freedom to select and frame news stories. We also find important differences between our samples of Western and Eastern European journalists