A Preliminary Examination of Power Relationships’ Influence on Reducing the Digitally Marginalized Student Population in Jamaica.

The Digital Divide has historically been viewed as the separation of people from technology based primarily on socio-economic issues and other demographic vulnerabilities. More recent studies have expanded research into investigating the impact of other societal structures such as the power of the government on equitable distribution of Information & Communication Technologies (ICTs) and other resources to the digitally marginalized population. While many strides have been made, educating children in the post-Covid era has made resolving the Divide a more pressing issue for students living in developing countries like Jamaica, where pre-pandemic, technology in education was still in its infancy. Using the Grounded Theory methodology, this research introduces preliminary findings demonstrating four power-relationships that have the power to and the power over effectively bridging the Divide and amongst the youngest of the digitally marginalized population and its effect on state-sponsored initiatives such as the OYOD

Worker-Job Recommendation for Mixed Crowdsourcing Systems: Algorithms, Models, Metrics and Service-Oriented Architecture

Crowdsourcing is used as model to distribute work over the Internet via an open call to anonymous human workers, who opt to take up work offerings sometimes for some small compensation. Increasingly, crowdsourcing systems are integrated into workflows to provide human computation capabilities. These workflows consist of machine-based workers that work harmoniously on different phases of a task with their human counterparts. This body of work addresses workflows where machines and human workers have the capacity to fulfill the requirements for same tasks. To maximize performance through the delegation of work to the most competent worker, this work outlines a collaborative filtering based approach with a bottom up evaluation based on workers' performance history and their inferred skillsets. Within the model, there are several algorithms, formulae and evaluative metrics. The work also introduces the notion of an Open Push-Pull model; a paradigm that maximizes on the services and strengths of the open call model, while seeking to address its weaknesses such as platform lock-in that affects access to jobs and availability of the worker pool. The work outlines the model in terms of a service-oriented architecture (SOA). It provides a supporting conceptual model for the architecture and an operational model that facilitates both human and machine workers. It also defines evaluative metrics for understanding the true capabilities of the worker pool. Techniques presented in this work can be used to expand the potential worker pool to compete for tasks through the incorporation of machine-oriented workers via virtualization and other electronic services, and human workers via existing crowds. Results in this work articulate the flexibility of our approach to support both human and machine workers within a competitive model while supporting tasks spanning multiple domains and problem spaces. It addresses the inefficiencies of current top-down approaches in worker-job recommendation through use of a bottom-up approach which adapts to dynamic and rapidly changing data. The work contrasts the shortcomings of top-down approaches' dependency on professed profiles which can be under-represented, over-represented or falsified in other ways with evaluative metrics that can be used for the individual and collective assessment of workers within a labor pool.Ph.D., Computer Science -- Drexel University, 201

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant

Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility

Several susceptibility loci for classical Hodgkin lymphoma (cHL) have been reported, however much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies (GWAS), a new GWAS, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all cHL at 6q22.33 (rs9482849, P=1.52 × 10-8) and for nodular sclerosis HL (NSHL) at 3q28 (rs4459895, P=9.43 × 10-17), 6q23.3 (rs6928977, P=4.62 × 10-55 11), 10p14 (rs3781093, P=9.49 × 10-13), 13q34 (rs112998813, P=4.58 × 10-8) and 16p13.13 (rs34972832, P=2.12 × 10-8). Additionally, independent loci within the HLA region are observed for NSHL (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity HL (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.In the United Kingdom, Bloodwise (LLR; 10021) provided principal funding for the study. Support from Cancer Research UK (C1298/A8362 supported by the Bobby Moore Fund) and the Lymphoma Research Trust is also acknowledged. A.S. is supported by a clinical fellowship from Cancer Research UK. For the UK-GWAS, sample and data acquisition were supported by Breast Cancer Now, the European Union and the Lymphoma Research Trust. The UK-GWAS made use of control genotyping data generated by the WTCCC. For further information, please visit the publishr's website

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant

A prenylated dsRNA sensor protects against severe COVID-19

Inherited genetic factors can influence the severity of COVID-19, but the molecular explanation underpinning a genetic association is often unclear. Intracellular antiviral defenses can inhibit the replication of viruses and reduce disease severity. To better understand the antiviral defenses relevant to COVID-19, we used interferon-stimulated gene (ISG) expression screening to reveal that OAS1, through RNase L, potently inhibits SARS-CoV-2. We show that a common splice-acceptor SNP (Rs10774671) governs whether people express prenylated OAS1 isoforms that are membrane-associated and sense specific regions of SARS-CoV-2 RNAs, or only express cytosolic, nonprenylated OAS1 that does not efficiently detect SARS-CoV-2. Importantly, in hospitalized patients, expression of prenylated OAS1 was associated with protection from severe COVID-19, suggesting this antiviral defense is a major component of a protective antiviral response

THE IMPACT OF U.S. BIOFUEL MANDATE WAIVER DECISIONS ON WORLD ETHANOL AND BIODIESEL MARKETS

Recently, the Environmental Protection Agency (EPA) proposed biofuel requirements for 2014 that suggest the use of ethanol would probably be lower than the volume previously envisioned in the Energy Independence and Security Act (EISA) of 2007. The impact of waiving down the mandate in the U.S., and shrinking the “advanced gap” will mean that both the U.S. and Brazil will export more to other countries. Given the flexibility the EPA has for setting policy, we analyze the impact of two alternative scenarios for mandate waivers on the U.S. domestic biofuel market and its implications for the world ethanol and biodiesel market: (1) overall mandate is waived down to a level which preserves the “advanced gap” at the levels envisioned in the RFS2; (2) overall mandate is achieved by expanding the biodiesel mandate is expanded from 1.28 billion gallons to 1.8 billion gallons. Increasing the advanced gap leads to both an increase in imports, but also an increase in exports of ethanol for the U.S., driven by the fact that the U.S. discriminates on the basis of feedstock where Brazil does not

Plastic sexual ornaments: Assessing temperature effects on color metrics in a color-changing reptile.

Conspicuous coloration is an important subject in social communication and animal behavior, and it can provide valuable insight into the role of visual signals in social selection. However, animal coloration can be plastic and affected by abiotic factors such as temperature, making its quantification problematic. In such cases, careful consideration is required so that metric choices are consistent across environments and least sensitive to abiotic factors. A detailed assessment of plastic trait in response to environmental conditions could help identify more robust methods for quantifying color. Temperature affects sexual ornamentation of eastern fence lizards, Sceloporus undulatus, with ventral coloration shifting from green to blue hues as temperatures rise, making the calculation of saturation (color purity) difficult under conditions where temperatures vary. We aimed to characterize how abiotic factors influence phenotypic expression and to identify a metric for quantifying animal color that is either independent from temperature (ideally) or best conserves individual's ranks. We compared the rates of change in saturation across two temperature treatments using seven metrics: three that are based on fixed spectral ranges (with two of them designed by us specifically for this system) and three that track the expressed hue (with one of them designed by us to circumvent spurious results in unornamented individuals). We also applied a lizard visual sensitivity model to understand how temperature-induced color changes may be perceived by conspecifics. We show that the rate of change in saturation between two temperatures is inconsistent across individuals, increasing at a higher rate in individuals with higher baseline saturation at lower temperatures. In addition, the relative color rank of individuals in a population varies with the temperature standardized by the investigator, but more so for some metrics than others. While we were unable to completely eliminate the effect of temperature, current tools for quantifying color allowed us to use spectral data to estimate saturation in a variety of ways and to largely preserve saturation ranks of individuals across temperatures while avoiding erroneous color scores. We describe our approaches and suggest best-practices for quantifying and interpreting color, particularly in cases where color changes in response to environmental factors