Radioisotope study of fructose adsorption at the alumina/electrolyte interface

The mechanism, kinetic and static studies of fructose adsorption at the alumina/electrolyte interface using radiolabeled 14C-fructose were conducted. Pseudo 2nd order model of adsorption kinetics was found to fit best to adsorption as a function of time. The fructose adsorption was found to decrease with increasing pH of the solution. Considering the changes in concentration of surface groups at the alumina/electrolyte interface, the hydrogen bonding is the most probable mechanism of interaction of fructose with the surface. This is confirmed by calorimetric titration experiments because the measured heat of adsorption was 10.8 kJ/mol. For the system studied the coverage of surface by fructose was several times smaller than the monolayer

Incomplete Cross-Bonding in the MV Line. Experience from the Operation of MV Single Cable Lines

Cable lines are one of the basic components of power systems. Medium and high voltage cables mainly comprise a metallic sheath, which is concentric to the main core conductor. There are several operating schemes of such cable lines, which differ in the place of earthing of sheaths and the possible use of the sheaths and/or conductors crossing. The sheaths cross-bonding is typically done in two places of one cable line section, and it allows to reduce power losses. Nevertheless, the use of incomplete sheaths crossing—only in one place on cable route may have economic justification. The paper presents an incomplete sheaths cross-bonding analysis of an existing medium voltage cable line. The results obtained by the mathematical model are validated by measurements taken on 30 October 2019 on an existing cable line. Measurements recorded on a real object for various systems of crossing sheaths are presented. The influence of incorrect sheaths crossing on the measured quantities was shown. In addition, the risk of excess voltage on the sheaths during short-circuits has been verified using a mathematical model

Krzyżowanie żył powrotnych w liniach kablowych SN w celu zmniejszenia strat energii czynnej

Currently, almost all medium voltage cable lines (MV) operate with the return wires earthed at both ends of the cable. Such a way of operation causes that during normal states of operation as well as during disturbances, e.g. short-circuits, in the return wires induce currents whose values mainly depend on the currents flowing in the phase wires. These currents in normal operating states are a source of additional energy losses incurred in the MV cables. The effect can be decreased by the return wires cross-bonding or the phase wires transposition. The paper discusses the potential effects that can be achieved by use of the return wires cross-bonding or the phase wires transposition in the domestic grids.Aktualnie u prawie wszystkich polskich operatorów sieci dystrybucyjnej (OSD) linie kablowe średniego napięcia (SN) pracują z żyłami powrotnymi uziemionymi na początku i na końcu linii. Taki układ pracy powoduje, że podczas stanów normalnych, jak i podczas zwarć, indukują się w żyłach powrotnych prądy, których wartości zależą głównie od prądów płynących w żyłach roboczych. Prądy te w stanach normalnych są źródłem dodatkowych strat przesyłowych ponoszonych w kablach SN. Artykuł zawiera dyskusję nad zasadnością stosowania transpozycji żył powrotnych lub żył roboczych w warunkach krajowych

The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure : one institution study

BACKGROUND: Gastrointestinal stromal tumors (GIST) mutational status is recognized factor related to the results of tyrosine kinase inhibitors therapy such as imatinib (IM) or sunitinib (SU). Arterial hypertension (AH) is common adverse event related to SU, reported as predictive factor in renal cell carcinoma. The aim of the study was to analyze the outcomes and factors predicting results of SU therapy in inoperable/metastatic CD117(+) GIST patients after IM failure. METHODS: We identified 137 consecutive patients with advanced inoperable/metastatic GIST treated in one center with SU (2(nd )line treatment). Median follow-up time was 23 months. Additionally, in 39 patients there were analyzed selected constitutive single nucleotide polymorphisms (SNPs) of VEGFA and VEGFR2 genes. RESULTS: One year progression-free survival (PFS; calculated from the start of SU) rate was 42% and median PFS was 43 weeks. The estimated overall survival (OS, calculated both from start of SU or IM) was 74 weeks and 51 months, respectively. One-year PFS was 65% (median 74 weeks) in 55 patients with AH vs. 22% (median 17 weeks) in patients without AH. Patients with primary tumors carrying mutations in KIT exon 9 or wild-type had substantially better 1-year PFS (68% and 57%; median 65.5 and 50.5 weeks, respectively) than patients having tumors with KIT exon 11 or PDGFRA mutations (34% and 15%; median 36.8 and 9 weeks, respectively). We identified two independent factors with significant impact on PFS and OS in univariate and multivariate analysis: primary tumor genotype and presence of AH. The most common adverse events during therapy were: fatigue, AH, hypothyroidism, hand and foot syndrome, mucositis, skin reactions, dyspepsia, and diarrhea. Two deaths were assessed as related to tumor rupture caused by reaction to SU therapy. The presence of C-allele in rs833061 and the T-allele in rs3025039 polymorphism of VEGFA were associated with significantly higher risk of hypothyroidism (OR: 10.0 p = 0.041 and OR: 10.5; p = 0.015, respectively). CONCLUSIONS: We confirmed that many advanced GIST patients benefit from SU therapy with OS > 1.5 year. Primary tumor KIT/PDGFRA genotype and SU-induced AH, as surrogate of its antiangiogenic activity are two independent factors influencing both PFS and OS. NOTE: The preliminary data of this study were presented during Annual Meeting of American Society of Clinical Oncology, 4-8 June 2011 and Connective Tissue Oncology Society Meeting, 26-28 October 2011 in Chicago, IL