Організаційно-педагогічні умови підготовки майбутнього педагога-музиканта в системі неперервної освіти

У статті досліджуються організаційно-педагогічні умови підготовки майбутнього педагога-музиканта в системі неперервної освіти.В статье исследуются организационно-педагогические условия подготовки будущего педагога-музыканта в системе непрерывного образования

Bélemnites de Valanginien : Nouvelles observations taxonomiques et stratigraphiques

Six new Valanginian belemnite species (Duvalia crassa sp. nov., Duvalia elongata sp. nov., Duvalia kleini sp. nov., Duvalia superconstricta sp. nov., Castellanibelus vaubellensis sp. nov., and "Hibolithes" lebresensis sp. nov.) are described here and two species (Duvalia aff. elongata and "Hibolithes" aff. pistilliformis (Blainville, 1827)) are left in open nomenclature. They come from both the distal and proximal parts of the Vocontian Basin in south-east France and the Baetic Cordillera in south-east Spain. In addition lectotypes are selected for Castellanibelus orbignyanus (Duval-Jouve, 1841), Castellanibelus picteti (Mayer, 1866), and Duvalia lata (Blainville, 1827).Six espèces nouvelles de bélemnites valanginiennes (Duvalia crassa sp. nov., Duvalia elongata sp. nov., Duvalia kleini sp. nov., Duvalia superconstricta sp. nov., Castellanibelus vaubellensis sp. nov. et "Hibolithes" lebresensis sp. nov.) sont décrites ici alors que deux autres (Duvalia aff. elongata et "Hibolithes" aff. pistilliformis (Blainville, 1827)) sont laissées en nomenclature ouverte. Elles proviennent des parties distales et proximales du bassin vocontien dans le sud-est de la France et des Cordillères bétiques dans le sud-est de l'Espagne. De plus, des lectotypes sont désignés pour les espèces Castellanibelus orbignyanus (Duval-Jouve, 1841), Castellanibelus picteti (Mayer, 1866), et Duvalia lata (Blainville, 1827)

Bélemnites néocomienne des régions méditerranéennes, 3ème partie : Bélemnites de l'intervalle Valanginien-Hauterivien

Les travaux classiques mais anciens de RASPAIL (1829, 1830) et DUVAL-JOUVE (1841) décrivent une grande variété d'espèces de bélemnites, provenant essentiellement du Crétacé inférieur de la région de Castellane-Peyroules (Alpes de Haute-Provence, France). Cette nouvelle contribution s'articule autour de la distribution biostratigraphique des bélemnites décrites précédemment car jusqu'à présent cet aspect avait été négligé. Le canevas biostratigraphique est calibré avec les successions lithologiques et les associations fauniques (ammonitofaune) de plusieurs affleurements dans cette région. Des données supplémentaires ont été obtenues à partir de coupes levées dans d'autres secteurs des Alpes de Haute-Provence: La Lagne, Les Allaves et Pas d'Escale. De plus, afin de mieux comprendre la distribution stratigraphique des bélemnites du Valanginien supérieur au sein de niveaux condensés glauconitiques ces associations sont comparées avec les bélemnites de milieux de dépôt plus profonds à Angles, à la Source de l'Asse de Moriez et à Cheiron, et avec celles des environs de La Charce et Vergol qui correspondent à des milieux plus profonds encore.The classical papers of RASPAIL (1829, 1830) and DUVAL-JOUVE (1841) described a wide range of belemnite species, mainly from the Lower Cretaceous of the Castellane-Peyroules area (Alpes de Haute-Provence, France). The present work focuses mainly on the biostratigraphy of these previously described belemnite taxa for their stratigraphic relationships had not been determined precisely. Here, biostratigraphy is related to the lithologic successions and faunal associations (ammonites) of various outcrops in the area studied. Complementary data were obtained from the La Lagne, Les Allaves and Pas d'Escale sections (Alpes de Haute-Provence, France). And, in order to attain a better understanding of the stratigraphic distribution of Late Valanginian belemnites in condensed glauconitic deposits, these assemblages are compared with belemnites from deeper water successions in the Angles, Source de l'Asse de Moriez, Cheiron areas and those in the vicinity of La Charce and Vergol that are even deeper

Computational tibial bone remodeling over a population after total knee arthroplasty:A comparative study

Periprosthetic bone loss is an important factor in tibial implant failure mechanisms in total knee arthroplasty (TKA). The purpose of this study was to validate computational postoperative bone response using longitudinal clinical DEXA densities. Computational remodeling outcome over a population was obtained by incorporating the strain‐adaptive remodeling theory in finite element (FE) simulations of 26 different tibiae. Physiological loading conditions were applied, and bone mineral density (BMD) in three different regions of interest (ROIs) was considered over a postoperative time of 15 years. BMD outcome was compared directly to previously reported clinical BMD data of a comparable TKA cohort. Similar trends between computational and clinical bone remodeling over time were observed in the two proximal ROIs, with most rapid bone loss taking place in the initial months after TKA and BMD starting to level in the following years. The extent of absolute proximal BMD change was underestimated in the FE population compared with the clinical subject group, which might be the result of significantly higher initial clinical baseline BMD values. Large differences in remodeling response were found in the distal ROI, in which resorption was measured clinically, but a large BMD increase was predicted by the FE models. Multiple computational limitations, related to the FE mesh, loading conditions, and strain‐adaptive algorithm, likely contributed to the extensive local bone formation. Further research incorporating subject‐specific comparisons using follow‐up CT scans and more extensive physiological knee loading is recommended to optimize bone remodeling more distal to the tibial baseplate

Maak het waar(d) : elektronisch informatieverkeer voor kleinere spelers in de keten

Kleine partijen - MKB-ers en consumenten - spelen vaak een sleutelrol in het realiseren van nieuwe concepten voor\ud elektronische communicatie in ketens en netwerken. Juist bij deze kleinere, en vaak talrijke, partijen spelen echter allerlei\ud obstakels die adoptie bemoeilijken

Mitosene-DNA adducts. Characterization of two major DNA monoadducts formed by 1,10-bis(acetoxy)-7-methoxymitosene upon reductive activation

Reductive activation of racemic 1,10-bis(acetoxy)-7-methoxymitosene WV15 in the presence of DNA, followed by enzymatic digestion and HPLC analysis, revealed the formation of various DNA adducts. Reduction is a necessary event for adduct formation to occur. This reductive activation was performed under hypoxic conditions in various ways:  (1) chemically, using a 2-fold excess of sodium dithionite (Na2S2O4), (2) enzymatically using NADH-cytochrome c reductase, (3) electrochemically on a mercury pool working electrode, and (4) catalytically, using a H2/PtO2 system. Five different mitosene−DNA adducts were detected. These adducts were also present when poly(dG-dC) was used instead of DNA, but were absent with poly(dA-dT). All were shown to be adducts of guanine. Reduction of 1,10-dihydroxymitosene WV14 in the presence of DNA did not result in detectable adduct formation, demonstrating the importance of good leaving groups for efficient adduct formation by these mitosenes. Finally, two of the adducts were isolated and their structures elucidated, using mass spectrometry, 1H NMR and circular dichroism (CD). The structures were assigned as the diastereoisomers N2-(1‘ ‘-n-hydroxymitosen-10‘ ‘-yl), 2‘-deoxyguanosine (n = α or β). These type of adducts, in which the mitosene C-10 is covalently bonded to the N-2 of a guanosylic group, are different from the well-known mitomycin C 2‘-deoxyguanosine monoadducts, that is linked via the mitomycin C C-1 position, demonstrating that the order of reactivity of the C-1 and C-10 in these mitosenes is reversed, as compared to mitomycin C. The 7-methoxy substituent of WV15 is a likely factor causing this switch. Evidence is presented that the 7-substituent of mitosenes also influences their DNA alkylation site. Adducts 4 and 5 represent the first isolated and structurally characterized covalent adducts of DNA and a synthetic mitosene

Bélemnites néocomiennes des régions méditerranéennes, 4ème partie: bélemnites de la coupe stratotypique du Barrémien

Cette étude aborde la distribution des bélemnites de l'Hauterivien terminal au Bédoulien inférieur de la Coupe Stratotypique du Barrémien d'Angles (ABSS). La distribution des bélemnites sur l'ABSS n'est pas uniforme, principalement due à l'inaccessibilité de certains bancs. Pour y remédier et pouvoir comparer leur distribution avec celle qui est observée en des domaines moins profonds, nous avons étudié d'autres localités comme les environs du Bourguet. Les sédiments de l'Hauterivien terminal ont fourni principalement Hibolithes ex gr. subfusiformis et quelques Duvalia ex gr. dilatata. Les sédiments du Barrémien basal ont livré une association plus riche comportant les dernières Hibolithes spp. Les premières bélemnites barrémiennes apparaissent juste un banc au dessus de la limite Hauterivien-Barrémien fondée sur les ammonites. Cette association de bélemnites (BaBA1) se compose de Duvalia ex gr. silesiaca-gagrica, Duvalia pontica et de plusieurs espèces d'Hibolithes. À la limite des zones à Nicklesia pulchella et Kotetishvilia compressissima, la diversité augmente et apparaissent alors les bélemnites "classiques" du Barrémien. Anciennement attribuées au genre Mesohibolites (BaBA2), ces espèces sont à présent rattachées au nouveau genre Shvetsovia. En association avec les duvaliidés de BaBA1 elles ont été initialement décrites dans l'Abkhazie par SHVETSOV (1913). Le Barrémien inférieur somminal (BaBA3) et la partie basale du Barrémien supérieur (BaBA4) montrent des associations de bélemnites diversifiées, avec de nombreuses espèces classiques. En particulier les niveaux du Barrémien inférieur terminal et du Barrémien supérieur basal montrent une association riche et diversifiée, dominée par quelques genres ressemblant étroitement aux vrais Mesohibolites. Ces associations de bélemnites sont ensuite comparées à celles de plusieurs coupes plus proximales dans le Bassin vocontien et à des zones situées en dehors du Bassin vocontien (principalement la Hongrie et la Géorgie). Certaines différences dans la fréquence et l'abondance de plusieurs espèces dans ces diverses coupes sont censées refléter des différences dans leur habitat naturel. Duvalia ex gr. grasiana semble être plus abondante dans les coupes les plus distales, tandis que les jeunes Mesohibolitidae, Conohibolites et Curtohibolites semblent être plus abondants dans les environnements plus proximaux. Les premiers Mesohibolites ont été récoltés dans le Barrémien supérieur (zone à Imerites giraudi) et les derniers dans le partie sommitale du "calcaire Bédoulien". Les premiers Neohibolites ont été récoltés dans la "zone non caractérisée" (Barrémien-Bédoulien) de l'ABSS, mais ce genre est plus fréquent dans les dépôts du "Bédoulien marneux". Les dépôts du Barrémien supérieur-Bédoulien inférieur se composent de sept associations de bélemnites, viz. BaBA5, BaBA6, BaBA7, BdBA1, BdBA2, BdBA3 et BdBA4. Pour conclure, une biozonation est présentée, définie par la distribution des bélemnites dans l'ABSS. Cette biozonation semble applicable dans les coupes les plus proximales, bien que certaines biozones puissent être diachrones. Les nouvelles espèces et les nouveaux genres suivants sont décrits: Hibolithes keleptrishvilii sp. nov. (Hauterivien terminal), Duvalia vermeuleni sp. nov. (Barrémien inférieur), Curtohibolites (?) bourguetensis sp. nov. (Barrémien inférieur), Shvetsovia gen. nov. (Barrémien) et Mesohibolites anglesensis sp. nov. (Barrémien supérieur). Enfin onze taxons ont été laissés en nomenclature ouverte.This paper deals with the distribution of belemnites in the latest Hauterivian to early Bedou-lian of the Angles Barremian Stratotype Section (ABSS). The distribution of the belemnites in the ABSS is not uniform, mainly due to the inaccessibility of certain beds. To cover this, and to compare the distribution with more proximal settings, we investigated a section to the north of Le Bourguet. The la-test Hauterivian sediments mainly yield Hibolithes ex gr. subfusiformis besides some Duvalia ex gr. dilatata. The earliest Barremian sediments deliver a richer association that yields the last Hibolithes spp. The first typical Barremian belemnites occur just one bed above the Hauterivian-Barremian boun-dary based on ammonites. This belemnite association (BaBA1) consists of Duvalia ex gr. silesiaca-gagrica, Duvalia pontica and several species of Hibolithes. At the boundary between the Nicklesia pul-chella and the Kotetishvilia compressissima zones the diversity increases and the first classical Barre-mian belemnites occur. These were formerly attributed to Mesohibolites (BaBA2). These species are herein attributed to a new genus Shvetsovia. Together with the duvaliids from BaBA1 they were first described from Abkhasia by SHVETSOV (1913). The latest Early Barremian (BaBA3) and the earliest Late Barremian (BaBA4) show well diversified belemnite associations, with many classical species, domina-ted by few genera closely resembling the true Mesohibolites. Eventually, these belemnite associations are compared to more proximal sections within the Vocontian Basin, and areas outside the Vocontian Basin (chiefly Hungary and Georgia). Some differences in the frequency and abundance of several spe-cies in these different palaeogeographical settings are believed to indicate differences in natural habi-tat. Duvalia ex gr. grasiana appears to be more abundant in more distal sections, while juvenile Meso-hibolitidae, Conohibolites and Curtohibolites appear to be more abundant in the more proximal environ-ments. Finally, a biozonation is presented and defined based on the distribution of the belemnites in the ABSS. This biozonation appears applicable in the more proximal sections, although some biozones are diachronous. The first Mesohibolites occur in the Upper Barremian Imerites giraudi Zone. In the Barremian-Bedoulian boundary sediments, as defined in the ABSS, Neohibolites first occurs, but the latter is only dominant in the marly sediments above the "calcareous Bedoulian". In the Late Barre-mian-early Bedoulian seven main belemnite associations can be distinguished, viz. BaBA5, BaBA6, BaBA7, BdBA1, BdBA2, BdBA3 and BdBA4. The following new species and genera are described: Hiboli-thes keleptrishvilii sp. nov. (latest Hauterivian), Duvalia vermeuleni sp. nov. (Early Barremian), Curto-hibolites (?) bourguetensis sp. nov. (Early Barremian), and Shvetsovia gen. nov. (late Early-early Late Barremian). Besides, the Late Barremian yields the new species Mesohibolites anglesensis. Moreover, eleven species are described in open-nomenclature

Subject-specific knee ligaments modeling approaches in finite element analysis: 1D and 3D

Knee ligaments are among the most complicated structures and have a large effect on knee biomechanics. There are different approaches to model the knee ligaments in FE models. In the knee joint, ligaments have been commonly modelled as 1D spring elements; moreover, some studies modelled the ligaments as 3D constitutive elements [2]. Using springs reduces computational costs compared to constitutive models of the ligaments. In turn, constitutive models closer approximate the anatomy, and facilitate the prediction of local quantities and interactions with surrounding tissues, such as wrapping [1]. To the best of our knowledge, there is no direct/practical comparison study between two FE ligament modelling approaches. The aim of this study is to develop and compare two separate subject-specific finite element knee models in terms of ligament modelling approaches, based on cadaveric validation experiments