Master of Science

thesisAlthough testosterone (T) has been dubbed the "hormone of desire," the link between T and sex drive has proven inconsistent among women. The mixed pattern of findings suggests that woman vary in the degree to which changes in T correspond to changes in sex drive (i.e., the T-drive linkage). Yet, to date no one has examined why this variation exists. The current study sought to answer 2 questions: First, within each individual woman, does T-drive linkage change as a function of ovulation? Second, is the overall degree of T-drive linkage higher in women with greater sexual motivation, greater average T, or greater daily variability in T, and among lesbian, bisexual or heterosexual women? We further explored how between-person and within-person characteristics interact to shape the T-drive linkage. To do this, we assessed daily T and daily sex drive over the middle 2 weeks of the menstrual cycle in a sample of 157 heterosexual, lesbian, and bisexual women. Multilevel modeling analyses demonstrated that lesbian and bisexual women showed a significant T-drive linkage, but only following ovulation, whereas heterosexual women had a significant T-drive linkage, but only prior to ovulation. Moreover, women with higher average T levels showed an inverse T-drive linkage prior to ovulation and a positive T-drive linkage following ovulation, whereas women with lower average T levels did not show a significant T-drive linkage during any ovulatory phase. Results suggest that considering menstrual cycle timing and trait-like characteristics are key to understanding variation in the T-drive linkage

Using SMS Text Messaging to Assess Moderators of Smoking Reduction: Validating a New Tool for Ecological Measurement of Health Behaviors

Objective: Understanding the psychological processes that contribute to smoking reduction will yield population health benefits. Negative mood may moderate smoking lapse during cessation, but this relationship has been difficult to measure in ongoing daily experience. We used a novel form of ecological momentary assessment to test a self-control model of negative mood and craving leading to smoking lapse. Design: We validated short message service (SMS) text as a user-friendly and low-cost option for ecologically measuring real-time health behaviors. We sent text messages to cigarette smokers attempting to quit eight times daily for the first 21 days of cessation (N-obs = 3,811). Main outcome measures: Approximately every two hours, we assessed cigarette count, mood, and cravings, and examined between- and within-day patterns and time-lagged relationships among these variables. Exhaled carbon monoxide was assessed pre- and posttreatment. Results: Negative mood and craving predicted smoking two hours later, but craving mediated the mood–smoking relationship. Also, this mediation relationship predicted smoking over the next two, but not four, hours. Conclusion: Results clarify conflicting previous findings on the relation between affect and smoking, validate a new low-cost and user-friendly method for collecting fine-grained health behavior assessments, and emphasize the importance of rapid, real-time measurement of smoking moderators

Subjective and Oxytocinergic Responses to Mindfulness Are Associated With Subjective and Oxytocinergic Responses to Sexual Arousal

Mindfulness – the ability to pay attention, on purpose, without judgment, and in the present moment – has consistently been shown to enhance women’s sexual arousal. As a first step toward understanding potential neuroendocrine underpinnings of mindfulness and sexual arousal, we examined whether individual differences in subjective and neuroendocrine (i.e., oxytocin) responses to mindful breathing were associated with individual differences in subjective and neuroendocrine responses to sexual arousal. To achieve this aim, 61 lesbian, bisexual, and heterosexual women completed a questionnaire assessing dispositional mindfulness, underwent an arousal task while continuously rating their sexual arousal and a mindful breathing task, after which participants reported on their ability to detect attentional shifts, and provided salivary samples after each assessment. Results indicated that women who were quicker to detect attentional shifts and women who reported greater sexual arousability reported larger changes (decreases) in oxytocin in response to mindful breathing and were the only women to report increases in oxytocin in response to the sexual arousal induction. Results further indicated that individuals who report greater subjective responsiveness to mindfulness and sexual arousal appear to have an oxytocinergic system that is also more responsive to both arousal and to mindfulness. These results make a significant contribution to our understanding of the role of attentional processes in sexual arousal, and warrant future examination of oxytocin as a potential neuroendocrine mechanism underlying the link between mindfulness and sexual arousal

Changing the landscape of mental health among college students: a community case study of a course on learning sustainable well-being

Our society is facing an unprecedented mental health crisis, with nearly one in two people being affected by mental health issues over their lifespan. This trend is especially noticeable among college students, who undergo significant shifts in social, familial, and academic responsibilities. Exacerbating the mental health crisis is the fact that students are facing other societal crises (e.g., climate change). And, in a reciprocal fashion, students experiencing poor mental health are less likely to feel resilient enough to tackle these other crises. In response to these colliding societal crises, we need a comprehensive solution that goes beyond the current models of college mental health services. We propose an alternative preventative mental health approach, which aims to prevent the onset of mental health concerns and build resilience in the face of colliding crises. Specifically, we argue that colleges can aid in building mental health resilience by creating for-credit courses that teach students the skills they need to be conscious, responsible, and resilient human beings. Toward this end, we created an experiential, workshop-style, 1 unit, P/NP course, entitled “Learning Sustainable well-being” (LSW), which guides students to explore, improve, and sustain their mental health. The principles taught in this course combine the wisdoms of several disciplines, including mindfulness, psychology, neuroscience, philosophy, religion, poetry, and cinema. The following community case study reflects on the journey of our “LSW initiative,” starting from the creation of the course in 2014 to the current mission of scaling up the offering as part of an institution-wide LSW program. To this end, we describe the LSW course modules/content, our pedagogical approach, potential limitations, and then provide data demonstrating its efficacy in improving student well-being. As a final note, we present the challenges we have faced, and the lessons learned, while on this journey. We hope that presenting this community case study will facilitate the growing dialogue across colleges about creating (and perhaps requiring) courses like LSW in order to improve students’ mental health and resilience in the context of other colliding crises

Neural correlates of focused attention during a brief mindfulness induction,”

Mindfulness meditationthe practice of attending to present moment experience and allowing emotions and thoughts to pass without judgmenthas shown to be beneficial in clinical populations across diverse outcomes. However, the basic neural mechanisms by which mindfulness operates and relates to everyday outcomes in novices remain unexplored. Focused attention is a common mindfulness induction where practitioners focus on specific physical sensations, typically the breath. The present study explores the neural mechanisms of this common mindfulness induction among novice practitioners. Healthy novice participants completed a brief task with both mindful attention [focused breathing (FB)] and control (unfocused attention) conditions during functional magnetic resonance imaging (fMRI). Relative to the control condition, FB recruited an attention network including parietal and prefrontal structures and trait-level mindfulness during this comparison also correlated with parietal activation. Results suggest that the neural mechanisms of a brief mindfulness induction are related to attention processes in novices and that trait mindfulness positively moderates this activation

Mental Health and Resilience in the Climate Crisis: A case study of well-being courses targeting college students

Our society is facing an unprecedented mental health crisis, with nearly one in two people being affected by mental health issues over their lifespan. This trend is especially noticeable among college students, who undergo significant shifts in social, familial, and academic responsibilities. Exacerbating these mental health issues is the emerging climate crisis. Although college students appear to have a heightened awareness of the climate crisis, such awareness can incite and exacerbate feelings of depression and helplessness, which – in turn – can impede their ability to affect climate change action. In response to these colliding crises of growing mental health and climate-related concerns, we need a comprehensive solution that goes beyond the current models of college mental health services. We propose an alternative preventative mental health approach, which aims to prevent the onset of mental health concerns and build resilience in the face of colliding crises. Specifically, we argue that colleges can aid in building mental health resilience by creating for-credit courses that teach students the skills they need to be conscious, responsible, and flourishing human beings. Toward this end, we created an experiential, workshop-style, 1 unit, P/NP course, entitled “Learning Sustainable Well-being” (LSW), which guides students to explore, improve, and sustain their mental health. The principles taught in this course combine the wisdoms of several disciplines, including mindfulness, psychology, neuroscience, philosophy, religion, poetry, and cinema. The following community case study reflects on the journey of our “LSW initiative”, starting from the creation of the course in 2014 to the current mission of scaling up the offering as part of an institution-wide LSW program. To this end, we describe the LSW course modules/content, our pedagogical approach, potential limitations, and then provide data demonstrating its efficacy in improving student well-being. As a final note, we present the challenges we have faced, and the lessons learned, while on this journey. We hope that presenting this community case study will facilitate the growing dialogue across colleges about creating (and perhaps requiring) courses like LSW in order to improve students’ mental health and resilience in the face of the climate crisis