Riverside space and local communities. Selected theoretical aspects

The presented article is dedicated to the analysis of selected theoretical aspects regarding the riverside space. The very concept of space is presented interdisciplinary as the subject of research in numerous fields of science. Most attention was paid to analyses riverside space in the context of human-river relations, and the mainstream consideration is the social role of the phenomenon, its social perception, and the resulting actions. The concept of space is connected here with the concept of local community, which supplements the issue, and their interdependence mainly results from the attributes and the process of creating that community. So in the article, a lot of space is devoted to theoretical considerations of these interrelationships and dependencies. Selected contemporary examples of revitalization and re-use of the riverside space and the social impact of these processes in urban areas are also presented

建築利用者の心理に対する建築理論家と実務家の多様な認識の研究 - 現代心理学の思考傾向の概念を用いて

早大学位記番号:新8141早稲田大

Wartości docelowe ciśnienia tętniczego u osób z chorobą wieńcową — spojrzenie po badaniu SPRINT

Nadciśnienie tętnicze jest jednym z głównych czynników ryzyka chorób układu sercowo-naczyniowego. Istotnie obciąża też rokowanie u osób po zawale serca lub z niewydolnością serca. Leczenie przeciwnadciśnieniowe poprawia rokowanie, także u osób z chorobą wieńcową. Opublikowane w ciągu ostatniego roku wyniki kilku dużych badań i analiz zmodyfikowały wytyczne postępowania w zakresie docelowego ciśnienia tętniczego. W artykule przedstawiono aktualne poglądy na docelowe ciśnienie tętnicze u osób z chorobą wieńcową.Hypertension is one of the major cardiovascular risk factors. High blood pressure is related to poor prognosis in patients with coronary artery disease or heart failure. Antihypertensive treatment improves prognosis, also in coronary artery disease patients. As recently published results of several trials and analyses have influenced guidelines (including guidelines of European Society of Cardiology) concerning blood pressure goals the article presents current views on blood pressure goals in patients with coronary artery disease

Czego fotografia może nauczyć architekta?

Koło Naukowe „Analog” zrzesza studentów Architektury Politechniki Łódzkiej, którzy kontynuują techniki czarno-białej fotografii analogowej. Artykuł przedstawia szereg umiejętności, jakich świadome fotografowanie może nauczyć architekta. Pierwszym omówionym zagadnieniem jest kompozycja. Autor przedstawia paralelę pomiędzy fotograficznymi zasadami komponowania kadru a architektonicznymi zasadami projektowania. W dalszej części omówione zostały inne umiejętności, takie jak świadome korzystanie z oświetlenia czy cechy charakteru przyszłego architekta, takie jak cierpliwość i kreatywność. Artykuł przybliża również działalność Koła Naukowego „Analog”. Opowiada o wystawie solarografii i współpracy z Muzeum Miasta Łodzi przy tworzeniu odbitek z płytek szklanych oraz wykorzystaniu tradycyjnych technik w ciemni.„Analog” Science Club unites Architecture Students of Łódź University of Technology, who continue black and white analog photography technic. Article presents a few skills, which can be taught by aware photography. First discussed topic is composition. Author presents relation between photographic composition rules and architectural design. Further there are mentioned other skills like aware usage of light or useful character traits like patience or creativity. Moreover article presents recent activities of “Analog” like solarography exhibitoion or cooperation with Łódź City Museum to create prints from archival glass plates; also other traditional techniques use in the darkroom

Comprehensive prediction in 78 human cell lines reveals rigidity and compactness of transcription factor dimers

The binding of transcription factors (TFs) to their specific motifs in genomic regulatory regions is commonly studied in isolation. However, in order to elucidate the mechanisms of transcriptional regulation, it is essential to determine which TFs bind DNA cooperatively as dimers and to infer the precise nature of these interactions. So far, only a small number of such dimeric complexes are known. Here, we present an algorithm for predicting cell-type-specific TF-TF dimerization on DNA on a large scale, using DNase I hypersensitivity data from 78 human cell lines. We represented the universe of possible TF complexes by their corresponding motif complexes, and analyzed their occurrence at cell-type-specific DNase I hypersensitive sites. Based on ~1.4 billion tests for motif complex enrichment, we predicted 603 highly significant celltype- specific TF dimers, the vast majority of which are novel. Our predictions included 76% (19/25) of the known dimeric complexes and showed significant overlap with an e xperimental database of protein-protein interactions. They were also independently supported by evolutionary conservation, as well as quantitative variation in DNase I digestion patterns. Notably, the known and predicted TF dimers were almost always highly compact and rigidly spaced, suggesting that TFs dimerize in close proximity to their partners, which results in strict constraints on the structure of the DNA-bound complex. Overall, our results indicate that chromatin openness profiles are highly predictive of cell-type-specific TF-TF interactions. Moreover, cooperative TF dimerization seems to be a widespread phenomenon, with multiple TF complexes predicted in most cell types. © 2013, Published by Cold Spring Harbor Laboratory Press.Link_to_subscribed_fulltex

SOXE transcription factors form selective dimers on non-compact DNA motifs through multifaceted interactions between dimerization and high-mobility group domains

The SOXE transcription factors SOX8, SOX9 and SOX10 are master regulators of mammalian development directing sex determination, gliogenesis, pancreas specification and neural crest development. We identified a set of palindromic SOX binding sites specifically enriched in regulatory regions of melanoma cells. SOXE proteins homodimerize on these sequences with high cooperativity. In contrast to other transcription factor dimers, which are typically rigidly spaced, SOXE group proteins can bind cooperatively at a wide range of dimer spacings. Using truncated forms of SOXE proteins, we show that a single dimerization (DIM) domain, that precedes the DNA binding high mobility group (HMG) domain, is sufficient for dimer formation, suggesting that DIM:HMG rather than DIM:DIM interactions mediate the dimerization. All SOXE members can also heterodimerize in this fashion, whereas SOXE heterodimers with SOX2, SOX4, SOX6 and SOX18 are not supported. We propose a structural model where SOXE-specific intramolecular DIM:HMG interactions are allosterically communicated to the HMG of juxtaposed molecules. Collectively, SO XE factors evolved a unique mode to combinatorially regulate their target genes that relies on a multifaceted interplay between the HMG and DIM domains. This property potentially extends further the diversity of target genes and cell-specific functions that are regulated by SOXE proteins.Link_to_subscribed_fulltex

Renal denervation in patients with symptomatic chronic heart failure despite resynchronization therapy : a pilot study

Introduction: Renal denervation (RD) has been shown to decrease sympathetic function in patients with hypertension. Its efficacy in symptomatic chronic heart failure (CHF) patients not responding to cardiac resynchronization therapy (CRT) has not been evaluated. Aim: To assess whether a less invasive treatment method – renal denervation – is safe in symptomatic heart failure patients despite optimal medical treatment and resynchronization therapy and whether it is associated with an improvement in clinical status, exercise capacity and hemodynamic parameters. Material and methods: The study was an open-label, randomized, controlled clinical trial. Patients were divided into an intervention (RD) and a control group. Clinical data collection, blood pressure (BP) measurements, echocardiography, 6-minute walk test (6MWT) and laboratory tests were performed before, 6 and 12 months after RD. The patients were followed-up to 24 months. Results: We included 20 patients aged 52.0 to 86.0 years (median age: 71.5 years), 15 males and 5 females with median left ventricular ejection fraction (LVEF) of 32.5%, body mass index 31.3 kg/m2. Renal denervation was safe, no significant adverse effects were registered. There were no significant differences in LVEF, BP, 6MWT and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) concentration 6 and 12 months after RD or control. Conclusions: Our results indicate that RD in CHF patients not responding to CRT is safe and does not worsen exercise capacity and hemodynamic parameters

Volunteer Computing Simulation Using Repast And Mason

Volunteer environments usually consist of a large number of computing nodes,with highly dynamic characteristics, therefore reliable models for a planning ofthe whole computing are highly desired. An easy to implement approach to mo-delling and simulation of such environments may employ agent-based universalsimulation frameworks, such as RePast or MASON. In the course of the paperthe above-mentioned simulation frameworks are adapted to support simulationof volunteer computing. After giving implementation details, selected resultsconcerning computing time and speedup are given and are compared with theones obtained from an actual volunteer environment

Long-term outcomes of the Coordinated Care Program in Patients after Myocardial Infarction (KOS-MI)

Background: The Coordinated Care in Myocardial Infarction Program (KOS-MI) was introduced to improve prognosis for patients after myocardial infarction (MI). The program includes complete revascularization followed by unrestricted access to rehabilitation, electrotherapy and cardiac care. Aim: The aim of this study was to assess major adverse cardiac and cerebrovascular events (MACCE) of patients enrolled in the KOS-MI at 3-year follow-up. Methods: This is a retrospective, multicenter registry of patients treated for MI. Study group (KOS-MI) of 963 patients was compared to the control group (standard of care) of 1009 patients. At 3-year follow-up MACCE including death, MI, stroke and repeated revascularization were reported. Additionally, hospitalization due to heart failure (HF) was analyzed. Propensity score matching (PSM) was utilized for group baseline characteristics adjustment. Results: Patients in the KOS-MI group were younger (65 vs. 68; P < 0.001), mostly men (70% vs. 62.9%; P < 0.001), admitted with ST-elevation myocardial infarction (STEMI) (44.6% vs. 36.2%; P < 0.001). Patients in the control group had more comorbidities and were admitted more often with non ST-elevation myocardial infarction (63.8% vs. 55.4%; P < 0.001) and acute HF (5.1% vs. 2.7%; P = 0.007). Following PSM 530 well matched pairs were selected. At three years (92.3% follow-up completeness), the relative risk reduction was: 25% in MACCE (P = 0.008), 38% in mortality (P = 0.008), 29% in repeated revascularization(P = 0.04) and 28% (P = 0.0496) in hospitalization for HF in the KOS-MI group. Conclusions: The combination of contemporary invasive techniques, complete revascularization, cardiac rehabilitation and ambulatory care included in the KOS-MI Program improves long-term prognosis of patients after MI up to 3-year follow-up