PacBio amplicon sequencing of Rysto homologues in wild potato species

Poster presented at EAPR Pathology & Pests Section Meeting, Arras, France The research leading to these results has received funding from the Norwegian Financial Mechanism 2014-2021, project DivGene: UMO2019/34/H/NZ9/0055

Diversity analysis of Rpi-ber1 and Rpi-vnt1 genes determining broad spectrum resistance to Phytophthora infestans

Poster presented at EAPR Pathology & Pests Section Meeting, Arras, France The research leading to these results has received funding from the Norwegian Financial Mechanism 2014-2021, project DivGene: UMO2019/34/H/NZ9/0055

High throughput analysis of Rpi genes in potato cultivars, breeding lines and wild Solanum species

Poster presented at 12TH INTERNATIONAL CONGRESS OF PLANT PATHOLOGY ICPP2023, Lyon, France The research leading to these results has received funding from the Norwegian Financial Mechanism 2014-2021, project DivGene: UMO2019/34/H/NZ9/0055

Amplicon sequencing of NBS LRR genes conferring resistance to Phytophthora infestans in potato

Poster presented at 2023 IS-MPMI Congress, Molecular Plant-Microbe Interactions, Providence, USA The research leading to these results has received funding from the Norwegian Financial Mechanism 2014-2021, project DivGene: UMO2019/34/H/NZ9/0055

Presence of homologues of the PVY resistance gene Rysto in wild relatives of potato

Poster presented at 12TH INTERNATIONAL CONGRESS OF PLANT PATHOLOGY ICPP2023, Lyon, France The research leading to these results has received funding from the Norwegian Financial Mechanism 2014-2021, project DivGene: UMO2019/34/H/NZ9/0055

Aggressiveness test of Phytophthora infestans isolates with different effector alleles

Poster presented at EAPR Pathology & Pests Section Meeting, Arras, France The research leading to these results has received funding from the Norwegian Financial Mechanism 2014-2021, project DivGene: UMO2019/34/H/NZ9/0055

Needs and ways to meet them by adolescents during adolescence

Kuszniar Klaudia, Firlej Ewelina, Janiszewska Mariola, Konarska Jagoda, Kustra Paulina, Barańska Agnieszka. Needs and ways to meet them by adolescents during adolescence. Journal of Education, Health and Sport. 2017;7(8):894-906. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.995619 http://ojs.ukw.edu.pl/index.php/johs/article/view/4861 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.08.2017. Revised: 10.08.2017. Accepted: 31.08.2017. Potrzeby oraz sposoby ich zaspokajania przez młodzież w okresie adolescencji Needs and ways to meet them by adolescents during adolescence Klaudia Kuszniar1, Ewelina Firlej2, Mariola Janiszewska2, Jagoda Konarska1, Paulina Kustra1, Agnieszka Barańska3 1Studenckie Koło Naukowe przy Zakładzie Informatyki i Statystyki Medycznej Uniwersytetu Medycznego w Lublinie 2Katedra Zdrowia Publicznego Uniwersytetu Medycznego w Lublinie 3Zakład Informatyki i Statystyki Medycznej Uniwersytetu Medycznego w Lublinie 1Student Scientific Group at the Department of Informatics and Medical Statistics of the Medical University of Lublin 2Department of Public Health of Medical University of Lublin 3Department of Informatics and Medical Statistics of Medical University of Lublin Streszczenie Wprowadzenie. Potrzeby człowieka wynikają z jego uwarunkowań biologicznych i psychicznych. Każda jednostka ze względu na swoją indywidualność generuje odmienne potrzeby. Szczególnie w okresie dorastania człowiek intensywniej odczuwa własne pragnienia. Pęd życia prowadzi go ku dorosłości oraz uniezależnienia od rodziców. Powoduje to chęć poznawania świata, ludzi oraz eksperymentowania. Młode osoby charakteryzuje impulsywność; szybkie i nieprzemyślane decyzje oraz zachowania ryzykowne. Cel. Celem pracy było ukazanie potrzeb oraz sposobów ich zaspokajania przez młodzież w wieku adolescencji. Podsumowanie. Potrzeby człowieka są różnorodne podobnie jak sposoby ich zaspokajania. Zaspokojenie potrzeb jest niezwykle istotne w prawidłowym funkcjonowaniu człowieka. Niezaspokojone potrzeby wpływają negatywnie na codzienne funkcjonowanie jednostki. W sytuacji, w której młode osoby nie są w stanie poradzić sobie z poczuciem braku, podświadomie motywują się do zapełnienia pustki. Budowanie hierarchii potrzeb u każdego człowieka przybiera inną formę, bowiem to czego ludziom brak zależy od ich poziomu inteligencji, wykształcenia, doświadczeń życiowych, środowiska, sytuacji rodzinnej czy materialnej. Istotne jest prowadzenie badań na temat potrzeb młodzieży oraz sposobów ich zaspokajania w okresie adolescencji, aby jak najlepiej wspierać młode osoby w realizacji własnych celów życiowych. Słowa kluczowe: okres dorastania, młodzież, hierarchia potrzeb Summary Introduction. The needs of man derive from his biological and psychological conditioning. Each unit, due to its individuality, generates different needs. Especially in adolescence, a person feels more strongly about his or her own desires. The drive of life leads him towards adulthood and independence from parents. This causes the desire to get to know the world, people and experiment. Young people are characterized by impulsiveness; quick and ill-considered decisions and risky behaviors. Target. The aim of the work was to show the needs and ways of satisfying them by youth in adolescence. Summary. The needs of man are varied as well as the ways of satisfying them. Satisfaction of needs is extremely important in the proper functioning of man. Unmet needs have a negative impact on the daily functioning of the individual. In a situation in which young people are unable to cope with a sense of lack, they are subconsciously motivated to fill emptiness. Building the hierarchy of needs for each person takes on a different form, because what people lack depends on their level of intelligence, education, life experiences, environment, family and material situation. It is important to conduct research on the needs of adolescents and how they can be met during adolescence in order to best support young people in achieving their own adult goals. Keywords: adolescence, youth, need, hierarchy of need

Differences in Avr-vnt1 alleles and aggressiveness in four European Phytophthora infestans lineages

Poster presented at 12TH INTERNATIONAL CONGRESS OF PLANT PATHOLOGY ICPP2023, Lyon, France The research leading to these results has received funding from the Norwegian Financial Mechanism 2014-2021, project DivGene: UMO2019/34/H/NZ9/0055

Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT1A receptor partial agonists

Current antidepressant therapy has several disadvantages related to the properties of antidepressants. Considering their unfavourable features, the process of searching for new antidepressant drugs with better safety and tolerability requires consistent efforts and many complementary studies. Serotonin 5-HT1A receptor is considered as an interesting target of antidepressant therapy. In the present study, the intrinsic activity at different signaling pathways coupled to serotonin 5-HT1A receptor, antidepressant-like and pharmacokinetic properties, and the safety profile of two novel imidazopurine-2,4-dione derivatives, namely compounds AZ-853 (8-(4-(4-(2-fluorophenyl)piperazin-1-yl)butyl)-1,3-dimethyl-1H- imidazo[2,1-f]purine-2,4(3H,8H)-dione) and AZ-861 (1,3-dimethyl-8-(4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)butyl)-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione), were studied in animal models through in vitro and in vivo experiments. We demonstrated that AZ-853 and AZ-861, which structurally differ by one substituent and its placement in the phenyl ring, showed varied functional, pharmacological, and pharmacokinetic properties as well as side effect profiles. AZ-861 exhibited stronger agonistic action in all functional assays. After acute and repeated administration in mice, both compounds showed antidepressant-like activity in the forced swim test, which was partially mediated by 5-HT1A receptor activation. AZ-853 showed a more potent antidepressant-like effect, presumably due to its better penetration into brain structures. Both compounds did not show anticholinergic properties, but after repeated administration, they induced weak sedation and lipid metabolism disturbances without affecting serum glucose level. The stronger α1-adrenolytic effect of AZ-853 is responsible for decreased systolic blood pressure, and in contrast to AZ-861, AZ-853 induced weight gain in mice. The interesting comparative pharmacological profiles of AZ-853 and AZ-861 encourage to conduct further experiments to fully understand their mechanisms and differences in action