Creating SAFE spaces for online learning in enabling maths courses

AIMS Transition Maths is a foundational maths unit offered fully online in pre-degree programs at the University of Tasmania, as well as through Open Universities Australia. The unit aims to prepare non-traditional and underrepresented students (such as first-in-family or of low socio-economic status) for tertiary study. Many of our students lack access to technology and established support networks; they often lack core mathematical skills and frequently recount previous negative experiences of formal maths education. These are both risk factors for maths anxiety (Khasawneh & Gosling, 2021). PEDAGOGICAL CONTEXT Our teaching approach is grounded in adult learning theory (Tate, 2012) and evidence-based practices (Brown, Roediger, & McDaniel, 2014) that lead to efficient learning for time poor students. We provide a rich suite of resources with a coherent structure and clear workflow for familiarity of process which assists with reducing anxiety. The workflow is closely aligned with weekly online contact sessions to enable real-time interactions which are designed to nurture a growth mindset where mistakes are celebrated as learning opportunities for all, rather than being seen as a failure of the individual. This has been shown to assist students with anxiety or depression to better cope with the stresses of university life (Dweck, 2017; p.38). We also use a differentiated instruction model and assessment framework to empower students to select the difficulty level at which they wish to work. LEARNING MODEL To overcome the isolation which can arise in online learning environments we focus on building relationships of trust through multimodal communication, both synchronous and asynchronous. We use team-teaching to create a learning community where participants have shared goals, space, and agency to decide how best to go about their learning (Hord, 2009). Activity-based sessions encourage group work and peer collaboration, and the presence of two teachers enables timely assistance, helping us to sustain the lively learning environment. Self-reflection is promoted at regular waypoints to ensure students achieve mathematical fluency and avoid the ‘illusion of knowing’ (Oakley, 2014). REFLECTION With a focus on open communication and relationship building we create safe spaces for effective online mathematics learning. Students report increasing confidence and they specifically acknowledge how motivated they became with our online team-teaching approach. REFERENCES Brown, P., Roediger, H., & McDaniel, M. (2014) Make it stick, Cambridge, MA: The Belknap Press. Dweck, C. (2017) Mindset: Changing the way you think to fulfil your potential, London: Robinson. Hord, S. (2009). Professional Learning Communities. Journal of Staff Development, 30(1), 40-43. Khasawneh, E., & Gosling, C. (2021). What impact does maths anxiety have on university students?, BMC Psychology, 9. https://doi.org/10.1186/s40359-021-00537-2 Oakley, B. (2014) A mind for numbers: How to excel at maths & science, New York: TarcherPerigee. Tate, M. (2012) “Sit & get” Won’t grow dendrites brain, London: SAGE Publications

Targeted ablation of oligodendrocytes induces axonal pathology independent of overt demyelination

The critical role of oligodendrocytes in producing and maintaining myelin that supports rapid axonal conduction in CNS neurons is well established. More recently, additional roles for oligodendrocytes have been posited, including provision of trophic factors and metabolic support for neurons. To investigate the functional consequences of oligodendrocyte loss, we have generated a transgenic mouse model of conditional oligodendrocyte ablation. In this model, oligodendrocytes are rendered selectively sensitive to exogenously administered diphtheria toxin (DT) by targeted expression of the diphtheria toxin receptor in oligodendrocytes. Administration of DT resulted in severe clinical dysfunction with an ascending spastic paralysis ultimately resulting in fatal respiratory impairment within 22 d of DT challenge. Pathologically, at this time point, mice exhibited a loss of ∼26% of oligodendrocyte cell bodies throughout the CNS. Oligodendrocyte cell-body loss was associated with moderate microglial activation, but no widespread myelin degradation. These changes were accompanied with acute axonal injury as characterized by structural and biochemical alterations at nodes of Ranvier and reduced somatosensory-evoked potentials. In summary, we have shown that a death signal initiated within oligodendrocytes results in subcellular changes and loss of key symbiotic interactions between the oligodendrocyte and the axons it ensheaths. This produces profound functional consequences that occur before the removal of the myelin membrane, i.e., in the absence of demyelination. These findings have clear implications for the understanding of the pathogenesis of diseases of the CNS such as multiple sclerosis in which the oligodendrocyte is potentially targeted

Older adults’ perspectives on physical activity and sedentary behaviour within their home using socio-ecological model

BackgroundThere are few studies that focus explicitly on the impact of the home environment on older adults’ sedentary behaviour (SB) and physical activity (PA) using the socio-ecological model (SEM). This study aims to investigate older adults’ PA and SB within the home environment integrating the SEM as a theoretical framework.MethodsA qualitative exploratory research design was employed to conduct 33 in-depth interviews (IDIs) and five focus group (FGs; n = 16) with multi-diverse ethnic older adults (mean age 72±5 years). Using reflexive thematic analysis themes were generated from the data set and were interpreted using the SEM.ResultsThe findings indicate that different levels of the SEM had an impact on older adults’ PA and SB. These include the 1) Individual level: Attitude, perception and motivation 2) Interpersonal level: Family and Friends: a motive to remain active 3) Organisational level: healthcare institutes, 4) Community level factors: Significance of social groups, 5) Physical Environment: Microenvironment and 6) Policy level factors (lockdown restrictions and healthcare system). This model can be utilised to foster activity within the home by focusing on the facilitators and barriers identified at each of these levels of influence.ConclusionThe study findings suggest that modifying PA and SB in the home environment is complex and is influenced across different levels of the SEM. Therefore, a holistic approach is required that integrates these multiple influences. This understanding can inform the design of interventions that seek to optimize PA and minimize SB within the home environment

Optimising older adults’ home spaces to enhance their physical activity level: an exploratory qualitative study protocol

Introduction:Housing is a major contributing factor to health, and better housing condition has been linked to improved general and psychological health. There has also been strong evidence that the physical environment within the home setting substantially impacts sedentary behaviour and physical activity in children. However, there is a lack of research that has investigated the physical environment within the home setting in the context of older adults’ physical activity levels and sedentary behaviour. Given that with increasing age, older adults spend large proportions of their time in their homes it is important to optimize older adults’ home settings to support healthy ageing. Therefore, the current study aims to explore older adults’ perceptions around optimizing their physical environment within their home space to support physical activity and subsequently facilitate healthy ageing. Methods and analysis:In this formative research, a qualitative exploratory research design using in-depth interviews (IDIs) and a purposive sampling approach will be employed. In-depth interviews will be conducted to collect data from study participants. Older adults from diverse community organizations in Swansea, Bridgend, and Neath Port Talbot will formally request approval to recruit via its contacts for this formative research. The study data will be analyzed thematically using NVivo V.12 Plus software.Ethics and dissemination:Ethical approval for this study has been obtained from the College of Engineering Research Ethics Committee (NM_31-03-22), Swansea University. The findings of the study will be disseminated to the scientific community and to the study participants. The results will enable us to explore the perceptions and attitudes of older adults towards physical activity within their home environment

Alcohol exposure during late gestation: Multiple developmental outcomes in sheep

Alcohol consumption during pregnancy remains common in many countries. Exposure to even low amounts of alcohol (i.e. ethanol) in pregnancy can lead to the heterogeneous fetal alcohol spectrum disorders (FASD), while heavy alcohol consumption can result in the fetal alcohol syndrome (FAS). FAS is characterized by cerebral dysfunction, growth restriction and craniofacial malformations. However, the effects of lower doses of alcohol during pregnancy, such as those that lead to FASD, are less well understood. In this article, we discuss the findings of recent studies performed in our laboratories on the effects of fetal alcohol exposure using sheep, in which we investigated the effects of late gestational alcohol exposure on the developing brain, arteries, kidneys, heart and lungs. Our studies indicate that alcohol exposure in late gestation can (1) affect cerebral white matter development and increase the risk of hemorrhage in the fetal brain, (2) cause left ventricular hypertrophy with evidence of altered cardiomyocyte maturation, (3) lead to a decrease in nephron number in the kidney, (4) cause altered arterial wall stiffness and endothelial and smooth muscle function and (5) result in altered surfactant protein mRNA expression, surfactant phospholipid composition and pro-inflammatory cytokine mRNA expression in the lung. These findings suggest that fetal alcohol exposure in late gestation can affect multiple organs, potentially increasing the risk of disease and organ dysfunction in later life

Reimaginar los servicios de bienestar infantil en América Latina: Hacia comunidades de excelencia

Children facing extreme poverty, abuse, and neglect often lack empowering care in welfare settings. This study developed and tested a model curriculum for training caregivers in two Peruvian Residential Care Centers using a sequential explanatory mixed-methods longitudinal design with 26 participants over three years. Findings demonstrate the curriculum’s practical value for caregiver training and emphasize the necessity of shifting organizational culture toward trauma-informed, strengths-based, and motivational practices. Achieving this transformation depends on committed leadership and increased organizational awareness, underscoring the importance of holistic change for effective, empowering support in residential child welfare environments. Los niños afectados por pobreza extrema, abuso y abandono suelen carecer de cuidados empoderadores en entornos de asistencia social. Este estudio diseñó y probó un plan de estudios para la formación de cuidadores en dos centros residenciales peruanos, utilizando un diseño longitudinal secuencial explicativo de métodos mixtos con 26 participantes durante tres años. Los resultados muestran el valor práctico del programa y resaltan la necesidad de transformar la cultura organizativa hacia enfoques basados en el trauma, fortalezas y motivación. Esta transformación exige liderazgo comprometido y mayor conciencia organizacional para lograr un apoyo infantil eficaz y empoderador

The Relationship Between Ambient Atmospheric Fine Particulate Matter (PM2.5) and Glaucoma in a Large Community Cohort.

Purpose: Glaucoma is more common in urban populations than in others. Ninety percent of the world's population are exposed to air pollution above World Health Organization (WHO) recommended limits. Few studies have examined the association between air pollution and glaucoma. Methods: Questionnaire data, ophthalmic measures, and ambient residential area air quality data for 111,370 UK Biobank participants were analyzed. Particulate matter with an aerodynamic diameter < 2.5 μm (PM2.5) was selected as the air quality exposure of interest. Eye measures included self-reported glaucoma, intraocular pressure (IOP), and average thickness of macular ganglion cell-inner plexiform layer (GCIPL) across nine Early Treatment Diabetic Retinopathy Study (ETDRS) retinal subfields as obtained from spectral-domain optical coherence tomography. We examined the associations of PM2.5 concentration with self-reported glaucoma, IOP, and GCIPL. Results: Participants resident in areas with higher PM2.5 concentration were more likely to report a diagnosis of glaucoma (odds ratio = 1.06, 95% confidence interval [CI] = 1.01-1.12, per interquartile range [IQR] increase P = 0.02). Higher PM2.5 concentration was also associated with thinner GCIPL (β = -0.56 μm, 95% CI = -0.63 to -0.49, per IQR increase, P = 1.2 × 10-53). A dose-response relationship was observed between higher levels of PM2.5 and thinner GCIPL (P < 0.001). There was no clinically relevant relationship between PM2.5 concentration and IOP. Conclusions: Greater exposure to PM2.5 is associated with both self-reported glaucoma and adverse structural characteristics of the disease. The absence of an association between PM2.5 and IOP suggests the relationship may occur through a non-pressure-dependent mechanism, possibly neurotoxic and/or vascular effects

BHPR research: qualitative1. Complex reasoning determines patients' perception of outcome following foot surgery in rheumatoid arhtritis

Background: Foot surgery is common in patients with RA but research into surgical outcomes is limited and conceptually flawed as current outcome measures lack face validity: to date no one has asked patients what is important to them. This study aimed to determine which factors are important to patients when evaluating the success of foot surgery in RA Methods: Semi structured interviews of RA patients who had undergone foot surgery were conducted and transcribed verbatim. Thematic analysis of interviews was conducted to explore issues that were important to patients. Results: 11 RA patients (9 ♂, mean age 59, dis dur = 22yrs, mean of 3 yrs post op) with mixed experiences of foot surgery were interviewed. Patients interpreted outcome in respect to a multitude of factors, frequently positive change in one aspect contrasted with negative opinions about another. Overall, four major themes emerged. Function: Functional ability & participation in valued activities were very important to patients. Walking ability was a key concern but patients interpreted levels of activity in light of other aspects of their disease, reflecting on change in functional ability more than overall level. Positive feelings of improved mobility were often moderated by negative self perception ("I mean, I still walk like a waddling duck”). Appearance: Appearance was important to almost all patients but perhaps the most complex theme of all. Physical appearance, foot shape, and footwear were closely interlinked, yet patients saw these as distinct separate concepts. Patients need to legitimize these feelings was clear and they frequently entered into a defensive repertoire ("it's not cosmetic surgery; it's something that's more important than that, you know?”). Clinician opinion: Surgeons' post operative evaluation of the procedure was very influential. The impact of this appraisal continued to affect patients' lasting impression irrespective of how the outcome compared to their initial goals ("when he'd done it ... he said that hasn't worked as good as he'd wanted to ... but the pain has gone”). Pain: Whilst pain was important to almost all patients, it appeared to be less important than the other themes. Pain was predominately raised when it influenced other themes, such as function; many still felt the need to legitimize their foot pain in order for health professionals to take it seriously ("in the end I went to my GP because it had happened a few times and I went to an orthopaedic surgeon who was quite dismissive of it, it was like what are you complaining about”). Conclusions: Patients interpret the outcome of foot surgery using a multitude of interrelated factors, particularly functional ability, appearance and surgeons' appraisal of the procedure. While pain was often noted, this appeared less important than other factors in the overall outcome of the surgery. Future research into foot surgery should incorporate the complexity of how patients determine their outcome Disclosure statement: All authors have declared no conflicts of interes