Boundedness and pointwise differentiability of weak solutions to quasi-linear elliptic differential equations and variational inequalities

summary:The local boundedness of weak solutions to variational inequalities (obstacle problem) with the linear growth condition is obtained. Consequently, an analogue of a theorem by Reshetnyak about a.e\. differentiability of weak solutions to elliptic divergence type differential equations is proved for variational inequalities

Role of membrane phospholipid remodeling, oxidative stress and PKC-δ upregulation in cardioprotection induced by chronic hypoxia

Úloha remodelace membránových fosfolipidů, oxidativního stresu a PKC-δ v kardioprotektivním účinku chronické hypoxie. Úvod: Kardiovaskulární choroby jsou nejčastější příčinou morbidity a mortality v rozvinutých zemích světa, proto se se řada experimentálních a klinických studií zabývá otázkou jak zvýšit toleranci myokardu k ischemicko/reperfúznímu (I/R) poškození. Předkládaná rigorózní práce se zabývá studiem mechanismů podílejících se na indukci endogenní kardioprotekce po adaptaci na intermitentní výškovou (IHA) hypoxii a vlivem diety obohacené tuky s různým zastoupením mastných kyselin (MK). Zaměřili jsme se na změny ve složení lipidů séra a srdečních buněk, expresi proteinkinázy C (PKC) a na markery oxidačního stresu a aktivitu antioxidačních enzymů v myokardu. Studovali jsme také roli reaktivních forem kyslíku (ROS) v kardioprotektivním účinku IHA hypoxie s použitím antioxidantu N- acetylcysteinu (NAC). Metodika: Experimenty byly prováděny na dospělých samcích potkana kmene Wistar. IHA hypoxie byla navozena v barokomoře, nadmořská výška 7000 m, 8 h denně, 5 dní v týdnu, 25 expozic. Zvířatům byla podávána standardní dieta a v dietním pokusu dieta obohacená 10% sádla (saturované - SFA a mononemnasycené MUFA), 10% kukuřičného oleje (n-6 polynenasycené MK, PUFA) a 10% rybího oleje (n-3 PUFA). NAC byl...Role of membrane phospholipid remodeling, oxidative stress and PKC- δ upregulation in cardioprotection induced by chronic hypoxia Introduction: Cardiovascular disease is the main cause of morbidity and mortality in industrially developed countries. Therefore, a number of experimental and clinical studies deal with the issue of how to increase tolerance to myocardial ischemia/reperfusion (I/R) injury. The present studies are concerned with mechanisms involved in the induction of endogenous cardioprotection after adaptation to intermittent altitude (IHA) hypoxia and influence of fat diets enriched with different fatty acids (FA) composition. We focused on changes in the composition of serum and heart lipids, the expression of PKC and on markers of oxidative stress and antioxidant enzyme activity in the myocardium. We also studied the role of reactive oxygen species (ROS) in the cardioprotective effect of IHA hypoxia using the antioxidant N-acetylcysteine (NAC). Methods: Adult male Wistar rats were exposed to IHA hypoxia in hyperbaric chamber, altitude 7000 m, 8 hours per day, 5 days a week, 25 exposures. Animals were fed by standard diet and diet enriched with 10% fat (saturated - SFA and MUFA mononemnasycené), 10% corn oil (n-6 polyunsaturated MK PUFA) and 10% fish oil (n-3 PUFA) in the diet experiment....Department of Cell BiologyKatedra buněčné biologiePřírodovědecká fakultaFaculty of Scienc

Work rehabilitation and its security provided by labour offices in the Ústecký region

Working rehabilitation is the topic of my diploma thesis. Finding out the ways of securing working rehabilitation by the employment offices in the region of Ústí nad Labem on the basis of secondary sources and qualitative talks is the aim of this diploma thesis. So far in the Czech Republic hasn´t been the system providing comprehensive solution of the health handicapped employment. The Act Employment n.435/2004, Code introduces the institute of working rehabilitation in order to provide the access and comeback to the labour market for the health handicapped. Supporting the policy which enable to employ these handicapped people is the the next objective of this institute. The employment offices as the state administration bodies provide the employment facilities in a given region, they are independent subjects, territorially organized in districts and their legislative duties contain working rehabilitation securing. Research respondents were the particular employment offices in the region of Ústí nad Labem personnel who are interested in working rehabilitation and really practise it. The region of ústí nad Labem belongs to the Czech Republic area maintaining the primacy in the field of the unemployment. The unemployment as a result of labour market functioning is one of the contemporary world problems. Labour market is very dynamic phenomenon which reacts to technological development and economic situation. Nowadayas with the essential decrease in working positions there is a decrease in free working positions reserved for the handicapped and thus the participation of the handiccaped in the total number of job applicants has been steadily increased. The integration of these handiccaped to the labour market is affected by lots of factors among others by insuficcient awareness of their needs and weak points of the contemporary functioning from the legistation and practise view point. Creating procedures which enable to make provision for needs and skills of working rehabilitation participants and thereby increasing their participation at labour market was the intention of this diploma thesis. The targets were fulfilled so there were suggested three variants which show various possibilities of the initiation of working rehabilitation process and enable the effective usage of their particular forms. The diploma thesis results can be used either by the employment offices personnel throughout the Czech Republic or by the specialized experts who are interested in the problem of working rehabilitation

What does it means to be an homosexual in the Czech society : the internet discussion community opinions of recent bill for registered partnership

Práce se snaží zachytit názory a argumentace účastníků internetových diskuzí k návrhu zákona o registrovaném partnerství a shrnuje dostupné informace vztahující se k projednávání zákona. Jádrem práce je analýza internetových diskuzí týkajících se tohoto tématu.Katedra sociálních vědDokončená práce s úspěšnou obhajobo

The influence of physical exercises on pregnant women on the development of labour

My work deals with the topic of ``Influence of Physical Exercises during Pregnancy on the Course of the Labour{\crqq}. I decided to explore this subject when I visited a course for pregnant women. I enjoyed the lecture I attended and I was interested whether the time and efforts that the women spent on the exercises were truly worth it. Already in the Antiquity and in the Early Middle Ages people took interest in health of pregnant women and their preparation for the labour. Doctors recommended to them relaxing more, best in lying positions, and bathing in hot water, and they forbade them to bathe in cold water. Based on those recommendations we can see that today{\crq}s psycho-prophylactic preparation of pregnant women has deep roots already in the old times of the Antiquity. The main objective of physical exercises in pregnancy is a good physical and mental condition. The labour and the actual pregnancy are very demanding in terms of the physical and mental fitness, and therefore it is good to be prepared for it. Proper physical exercises help women manage the increased demands on their organisms during the pregnancy, and after the labour it helps them with easier and quicker return to their body weight before the pregnancy. The exercises especially designed for pregnant women prepare them for the labour so that it was as easy for them as possible and did not exhaust them more than it was necessary. Whether the exercise is suitable for the woman or not must be assessed by her doctor on individual basis and based on the current health condition of the woman and her foetus, on the length of pregnancy, physical condition of the woman etc. The goal of this work was to find out whether the physical exercises during the pregnancy truly influence the course of the physiological labour. In order to collect all information I carried out a quantitative research in the form of a questionnaire and I also applied information regarding the length of the labour I had acquired from the medical documentation of women after their physiological labour hospitalized in the lying-in clinic. Before I launched the research I had established a hypothesis that women who had underwent any kind of physical exercises during their pregnancy had faster course of the labour than those who had not attended any such courses. A more significant difference in the length of the labour has been recorded only in case of multiparas who had not done any physical exercises during their pregnancy. The research showed that women (multiparas) who attended any course for pregnant women during their pregnancy have shorter labour approximately by 49 minutes than those women (multiparas) who did not do any exercises. This work could help midwives who lead antenatal courses for pregnant women as part of their primary care. The information could be also provided to the medical staff who meet pregnant women in their practice (for instance in gynaecological departments) and who could deliver the information to them

Integration of a Child with Phenylketon

Fenylketonurie je pro většinu lidí neznámým pojmem. Z výsledků průzkumu u rodičů dětí majících PKU vyplývá, že pouze jeden z dvaceti rodičů znal tento pojem před diagnózou dítěte. Po sdělení diagnózy v sobě rodiče objevují síly, které dosud nebyly využity. Je nutné na sebe vzít břemeno nových požadavků, nový režim rodiny, zvýšené finanční nároky, časové požadavky. Důležité je, aby si rodiče jednotlivě i společně utřídili a ujasnili vše, na co spoléhají, kdo nebo co jim může pomoci

Nursing Care of the Patient with Obesity Immobile

Department of Nursing 3FM CUÚstav ošetřovatelství 3. LF UKThird Faculty of Medicine3. lékařská fakult

Novel approaches to diagnosis and treatment of selected endocrine disorders

Je známou zkušeností, že hyperkortizolismus urychluje aterosklerotické děje. Ty je možné sledovat ultrazvukovým vyšetřováním karotid a nověji též vyšetřováním cévní mikrocirkulace laser-Dopplerovskou metodou. Pro urychlení aterosklerotických změn u nemocných s Cushingovým syndromem jsou nesporně důležité známé faktory: hypertenze, obezita a hyperlipidemie. К nim se počítá zvýšená inzulínová rezistence, ale nemocní s floridním hyperkortizolismem mají normální hladiny glykemie a imunoreaktivního inzulínu. К aterogenezi u floridního hyperkortizolismu může přispívat zvýšená tvorba volných kyslíkových radikálů vznikajících při oxidaci lipidů a zvýšené hladiny pozitivního proteinu akutní fáze-orosomukoidu. Imunosupresivní charakter se projevuje snížením hladin autoprotilátek a snížením hladiny intercelulární adhezivní molekuly-1 (ICAM-1). К urychlení aterogeních dějů dochází i u nemocných, kteří jsou již dlouhou dobu po úspěšné normalizaci hyperkortizolemie. I když čerstvě operovaní a normalizovaní nemocní ztrácí do jednoho roku svou Cushingovskou obezitu, dochází později u operovaných nemocných opět к nadváze. Ta je spojena s poruchami lipidového spektra a u čtvrtiny nemocných i s hypertenzí. Nemocné po operaci pro Cushingův syndrom je nutné pravidelně sledovat, i když jsou dlouhodobě normalizováni. Je třeba u..

Role of membrane phospholipid remodeling, oxidative stress and PKC-δ upregulation in cardioprotection induced by chronic hypoxia

Role of membrane phospholipid remodeling, oxidative stress and PKC- δ upregulation in cardioprotection induced by chronic hypoxia Introduction: Cardiovascular disease is the main cause of morbidity and mortality in industrially developed countries. Therefore, a number of experimental and clinical studies deal with the issue of how to increase tolerance to myocardial ischemia/reperfusion (I/R) injury. The present studies are concerned with mechanisms involved in the induction of endogenous cardioprotection after adaptation to intermittent altitude (IHA) hypoxia and influence of fat diets enriched with different fatty acids (FA) composition. We focused on changes in the composition of serum and heart lipids, the expression of PKC and on markers of oxidative stress and antioxidant enzyme activity in the myocardium. We also studied the role of reactive oxygen species (ROS) in the cardioprotective effect of IHA hypoxia using the antioxidant N-acetylcysteine (NAC). Methods: Adult male Wistar rats were exposed to IHA hypoxia in hyperbaric chamber, altitude 7000 m, 8 hours per day, 5 days a week, 25 exposures. Animals were fed by standard diet and diet enriched with 10% fat (saturated - SFA and MUFA mononemnasycené), 10% corn oil (n-6 polyunsaturated MK PUFA) and 10% fish oil (n-3 PUFA) in the diet experiment...