The Scenic Beauty of Geosites and Its Relation to Their Scientific Value and Geoscience Knowledge of Tourists: A Case Study from Southeastern Spain

Scenic beauty is one of the most-commonly used indicators in the inventory and assessment of geosites for geoconservation, geoheritage management and geotourism development. It is an important driver of tourists to visit natural areas and it also provides support for the protection of natural heritage. Previous studies on scenic beauty mainly focused on landscape preference and physical characteristics of geosites that affect scenic beauty appreciation. The relationships between the scenic beauty of geosites, their scientific value and the geoscience knowledge of tourists has not been empirically investigated in detail. Hence, this study investigates this relationship using 34 geosites from southeastern Spain. For this purpose, 29 respondents with a geoscience background and who all visited the 34 geosites, 43 respondents with a geoscience background but who did not visit the geosites, and 104 respondents with no geoscience background and who did not visit the geosites, participated in a survey. The first group rated the scenic beauty and the scientific value of the geosites based on a direct field visit during which the scientific background of these geosites was given. On the other hand, the latter two groups rated scenic beauty using representative photos of the geosites. A five-point Likert scale was used to rate the scenic beauty and the scientific value of the geosites. We found a significant relationship between the scenic beauty of geosites and their scientific value, and this relationship becomes more significant if the geoscientific knowledge of the respondents increases. One-way ANOVA results indicated that a geoscience background contributed to higher perceived scenic beauty, especially for those geosites that in general were considered as more scenic by all the respondent groups. It was also found that geosites with viewpoints received in general higher scenic beauty and scientific value ratings

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP as a clinical target against asthma calls for maximally harnessing its therapeutic potential via structural and mechanistic considerations. Here we employ an integrative experimental approach focusing on productive and antagonized TSLP complexes and free cytokine. We reveal how cognate receptor TSLPR allosterically activates TSLP to potentiate the recruitment of the shared interleukin 7 receptor a-chain (IL-7Ra) by leveraging the flexibility, conformational heterogeneity and electrostatics of the cytokine. We further show that the monoclonal antibody Tezepelumab partly exploits these principles to neutralize TSLP activity. Finally, we introduce a fusion protein comprising a tandem of the TSLPR and IL-7Ra extracellular domains, which harnesses the mechanistic intricacies of the TSLP-driven receptor complex to manifest high antagonistic potency

Do tourists' preferences match the host community's initiatives? : a study of sustainable tourism in one of Africa's oldest conservation areas

Involvement of stakeholders in sustainable tourism, particularly in developing countries, is crucial for the success of tourism development. However, its implementation is often criticized for not considering stakeholders' needs. This study explores tourists' preferences for tourism activities, designed by local stakeholders, in one of the oldest conserved parks in East Africa-the Menagesha Suba Forest, in the Central Highlands of Ethiopia. The study area is endowed with natural, cultural and historical, yet undeveloped, tourist attractions. The host community benefits little from tourism and is in continual conflict with the park administration. This study aims to provide new insights on potential engagement of stakeholders in sustainable tourism planning. In particular, we explored tourists' preferences for activities designed by local stakeholders, as well as their preferences concerning the improvement of the park infrastructure. The local community has been engaged in group discussions to design community involvement activities in tourism, while park guest books have been consulted to identify infrastructure improvements suggested by tourists. A survey that embedded a discrete choice experiment was conducted among tourists that visited the Menagesha Suba Forest. Data were analyzed with mixed logit and latent class models. We identified preferences for infrastructure improvement in the park. Tourists' preferences are heterogeneous and vary with their profile as foreigners, foreign residents, and locals. Furthermore, the study indicates that there is a mismatch between tourists' preferences and activities designed by the host community for their engagement in tourism. Tourists might be unaware of the importance of such activities for local communities. On the other hand, the findings also imply that increasing host residents' awareness of tourism and tourists' preferences is required, prior to tourism activities planning. Hence, sustainable tourism planning and development needs to understand perception gaps between host residents and tourists for its smooth implementation

Isabelle Modelchecking for insider threats

The Isabelle Insider framework formalises the technique of social explanation for modeling and analysing Insider threats in infrastructures including physical and logical aspects. However, the abstract Isabelle models need some refinement to provide sufficient detail to explore attacks constructively and understand how the attacker proceeds. The introduction of mutable states into the model leads us to use the concepts of Modelchecking within Isabelle. Isabelle can simply accommodate classical CTL type Modelchecking. We integrate CTL Modelchecking into the Isabelle Insider framework. A running example of an IoT attack on privacy motivates the method throughout and illustrates how the enhanced framework fully supports realistic modeling and analysis of IoT Insiders

Application of Simple Smart Logic for Waterflooding Reservoir Management

A simple smart logic for controlling inflow control valves (ICV) in waterflooding reservoir management is implemented and analyzed, with the final objective of improving the long term financial return of a petroleum reservoir. Such a control is based in a reactive simple logic that responds to the watercut measured in the ICV. Basically, when the watercut increases, the ICV is set to close proportionally. For comparison purposes, four strategies are presented: base case scenario with conventional control, the best completion configuration found by trial-and-error, the reactive control, and a deterministic optimal control based on Nonlinear Gradient Method with adjoint-gradient formulation is shown for comparison purposes. Finally, all four strategies are tested again in different reservoir realizations in order to mimic the geological uncertainties. Two different synthetic reservoir models were studied. First, a simple cube with a five-spot well configuration, in which the permeability field has a horizontal pattern defined by lognormal distributions. The second model is a benchmark proposed by the Dutch university, TU delft, with 101 channelized permeability fields representing river patterns. For the first model, no significant relative gain is found neither in the variable control nor in the optimal control. Manly because of the high homogeneity of the reservoir models. Therefore, no intelligent completion is recommended. On the other hand, for the second and more complex case, the results indicate an expressive relative gain in the use of simple reactive logic. Besides, this type of control achieves results nearly as good as the optimal control. The test in different realizations, however, shows that reservoir characterization is still a key part of any attempt to improve production. Although the variable reactive control is semi-independent, with action being taken based on measurements, some parameters need a priori model to be tuned

Using observational data to emulate a randomized trial of dynamic treatment switching strategies

BACKGROUND: When a clinical treatment fails or shows suboptimal results, the question of when to switch to another treatment arises. Treatment switching strategies are often dynamic because the time of switching depends on the evolution of an individual's time-varying covariates. Dynamic strategies can be directly compared in randomized trials. For example, HIV-infected individuals receiving antiretroviral therapy could be randomized to switching therapy within 90 days of HIV-1 RNA crossing above a threshold of either 400 copies/ml (tight-control strategy) or 1000 copies/ml (loose-control strategy).METHODS: We review an approach to emulate a randomized trial of dynamic switching strategies using observational data from the Antiretroviral Therapy Cohort Collaboration, the Centers for AIDS Research Network of Integrated Clinical Systems and the HIV-CAUSAL Collaboration. We estimated the comparative effect of tight-control vs. loose-control strategies on death and AIDS or death via inverse-probability weighting.RESULTS: Of 43 803 individuals who initiated an eligible antiretroviral therapy regimen in 2002 or later, 2001 met the baseline inclusion criteria for the mortality analysis and 1641 for the AIDS or death analysis. There were 21 deaths and 33 AIDS or death events in the tight-control group, and 28 deaths and 41 AIDS or death events in the loose-control group. Compared with tight control, the adjusted hazard ratios (95% confidence interval) for loose control were 1.10 (0.73, 1.66) for death, and 1.04 (0.86, 1.27) for AIDS or death.CONCLUSIONS: Although our effective sample sizes were small and our estimates imprecise, the described methodological approach can serve as an example for future analyses

Du grand conseil de Philippe le Bon au parlement de malines de Charles le Téméraire

Van Rompaey Jan. Du grand conseil de Philippe le Bon au parlement de malines de Charles le Téméraire. In: Revue du Nord, tome 61, n°240, Janvier-mars 1979. pp. 213-214

Gilissen (John), Belgique et Nord de la France

Van Rompaey Jan. Gilissen (John), Belgique et Nord de la France. In: Revue belge de philologie et d'histoire, tome 53, fasc. 4, 1975. Histoire (depuis l'Antiquité) — Geschiedenis (sedert de Oudheid) pp. 1375-1378