Estimation of the power electronic converter lifetime in fully rated converter wind turbine for onshore and offshore wind farms

A comparison has been made of the converter lifetime for a 3MW fully rated converter horizontal axis wind turbine located onshore and offshore. Simulated torque and speed of the turbine shaft were used to calculate voltage and current time series, that was used to calculate the junction temperatures of the diode and IGBT in the generator-side converter by a thermal-electrical model. A rainflow counting algorithm was applied to the junction temperature in combination with an empirical model of the lifetime estimation, to calculate the lifetime of the power electronic modules in the turbine. The number of parallel modules for each location to achieve 20 years life time has also been found. Simulations show the lifetime consumption rate of the diode and IGBT is decreased exponentially by increasing number of parallel modules, lowering the average temperature. The offshore wind turbine has a higher lifetime consumption rate, requiring a slightly higher converter rating to achieve a 20-year lifetime, but this difference is small, and both turbines will use the same number of modules

xD-Track: Leveraging Multi-Dimensional Information for Passive Wi-Fi Tracking

We describe the design and implementation of xD-Track, the first practical Wi-Fi based device-free localization system that employs a simultaneous and joint estimation of time-of-flight, angle-of-arrival, angle-of-departure, and Doppler shift to fully characterize the wireless channel between a sender and receiver. Using this full characterization, xD-Track introduces novel methods to measure and isolate the signal path that reflects off a person of interest, allowing it to localize a human with just a single pair of access points, or a single client-access point pair. Searching the multiple dimensions to accomplish the above is highly computationally burdensome, so xD-Track introduces novel methods to prune computational requirements, making our approach suitable for real-time person tracking. We implement xD-Track on the WARP software-defined radio platform and evaluate in a cluttered office environment. Experiments tracking people moving indoors demonstrate a 230% angle-of-arrival accuracy improvement and a 98% end-to-end tracking accuracy improvement over the state of the art localization scheme SpotFi, adapted for device-free localization. The general platform we propose can be easily extended for other applications including gesture recognition and Wi-Fi imaging to significantly improve performance

What is the best way to manage phantom limb pain?

No single best therapy for phantom limb pain (PLP) exists. Treatment requires a co- ordinated application of conservative, pharmacologic, and adjuvant therapies. Evaluative management (including prosthesis adjustment, treatment of referred pain, and residual limb care) should be tried initially (strength of recommendation [SOR]: C, expert opinion). Other first-line treatments such as transcutaneous electrical nerve stimulation (TENS) (SOR: A, multiple high-quality randomized, control trials [RCTs]), and biofeedback (SOR: B, numerous case studies) can reduce PLP. Pharmaco- therapy, including opioids, anticonvulsants (gabapentin), and nonsteroidal anti- inflammatory drugs (NSAIDs), can also relieve pain (SOR: B, initial RCTs and inconsistent findings)

Augmenting Wide-band 802.11 Transmissions via Unequal Packet Bit Protection

Due to frequency selective fading, modern wide-band 802.11 transmissions have unevenly distributed bit BERs in a packet. In this paper, we propose to unequally protect packet bits according to their BERs. By doing so, we can best match the effective transmission rate of each bit to channel condition, and improve throughput. The major design challenge lies in deriving an accurate relationship between the frequency selective channel condition and the decoded packet bit BERs, all the way through the complex 802.11 PHY layer. Based on our study, we find that the decoding error of a packet bit corresponds to dense errors in the underlying codeword bits, and the BER can be truthfully approximated by the codeword bit error density. With above observation, we propose UnPKT, scheme that protects packet bits using different MAC-layer FEC redundancies based on bit-wise BER estimation to augment wide-band 802.11 transmissions. UnPKT is software-implementable and compatible with the existing 802.11 architecture. Extensive evaluations based on Atheros 9580 NICs and GNU-Radio platforms show the effectiveness of our design. UnPKT can achieve a significant goodput improvement over state-of-the-art approaches

Absorbent products for urinary/faecal incontinence: a comparative evaluation of key product designs

Background: The UK health service, nursing homes and public spend around £94 million per year on incontinence pads (absorbent products) to contain urine and/or faeces, but the research base for making informed choices between different product designs is very weak.Objectives: The aim of this trial was to compare the performance and cost-effectiveness of the key absorbent product designs to provide a more solid basis for guiding selection and purchase.A further aim was to carry out the first stage in the development of a quality of life instrument for measuring the impact of absorbent product use on users' lives.Design: The work involved three clinical trials focusing on the three biggest market sectors. Each trial had a similar crossover design in which each participant tested all products within their group in random order.Settings, participants and methods: In Trial 1, 85 women with light urinary incontinence living in the community tested three products from each of the four design categories available (total of 12 test products): disposable inserts (pads); menstrual pads; washable pants with integral pad; and washable inserts. In Trial 2a, 85 moderate/heavily incontinent adults (urinary or urinary/faecal) living in the community (49 men and 36 women) tested three (or two) products from each of the five design categories available (total of 14 test products): disposable inserts (with mesh pants); disposable diapers (nappies); disposable pull-ups (similar to toddlers' trainer pants); disposable T-shaped diapers (nappies with waist-band); and washable diapers. All products were provided in a daytime and a (mostly more absorbent) night-time variant. In these first two trials, the test products were selected on the basis of data from pilot studies. In Trial 2b, 100 moderate/heavily incontinent adults (urinary or urinary/faecal) living in 10 nursing homes (27 men and 73 women) evaluated one product from each of the four disposable design categories from Trial 2a. Products were selected on the basis of product performance in Trial 2a and, again, daytime and night-time variants were provided. The first phase of work to develop a quality of life tool for measuring the impact of using different pad designs was carried out by interviewing participants from Trials 1 and 2a.Outcome measures: Product performance was characterised using validated questionnaires, which asked the participants (in Trials 1 and 2a) or carers (all participants in Trial 2b, except for the few who could report for themselves) to evaluate various aspects of pad performance (leakage, ease of putting on, discreetness, etc.) using a five-point scale (very good–very poor) at the end of the week (or 2 weeks for Trial 2b) of product testing. In addition, participants/carers were asked to save individual used pads in bags for weighing and to indicate the severity of any leakage from them on a three-point scale (none, a little, a lot). These data were used to determine differences in leakage performance. Numbers of laundry items and pads used were recorded to estimate costs, and skin health changes were recorded by the participant or by the researchers (Trial 2b). At the end of testing, participants were interviewed and ranked their preferences (with and without costs), stated the acceptability of each design (highly acceptable–totally unacceptable) and recorded their overall opinion on a visual analogue scale (VAS) of 0–100 points (worst design–best design). This VAS score was used with product costs to estimate cost-effectiveness. In addition, a timed pad changing exercise was conducted with 10 women from Trial 2b to determine any differences between product designs.Results: Results presented are for statistically and clinically significant findings.<br/

Analyzing the effects of surface distribution of pores in cell electroporation for a cell membrane containing cholesterol

This paper presents a model and numerical analysis (simulations) of transmembrane potential induced in biological cell membrane under the influence of externally applied electric field (i.e., electroporation). This model differs from the established models of electroporation in two distinct ways. Firstly, it incorporates the presence of cholesterol (~20% mole-fraction) in biological membrane. Secondly, it considers the distribution of pores as a function of the variation of transmembrane potential from one region of the cell to another. Formulation is based on the role of membrane tension and electrical forces in the formation of pores in a cell membrane, which is considered as an infinitesimally thin insulator. The model has been used to explore the process of creation and evolution of pores and to determine the number and size of pores as a function of applied electric field (magnitude and duration). Results show that the presence of cholesterol enhances poration by changing the membrane tension. Analyses indicate that the number of pores and average pore radii differ significantly from one part of the cell to the other. While some regions of the cell membrane undergo rapid and dense poration, others remain unaffected. The method can be a useful tool for a more realistic prediction of pore formation in cells subjected to electroporation.Comment: 11 pages, 3 figures. v2: added new references, grammatical changes, corrected typo

Microarray analyses demonstrate the involvement of type i interferons in psoriasiform pathology development in D6-deficient mice

The inflammatory response is normally limited by mechanisms regulating its resolution. In the absence of resolution, inflammatory pathologies can emerge, resulting in substantial morbidity and mortality. We have been studying the D6 chemokine scavenging receptor, which played an indispensable role in the resolution phase of inflammatory responses and does so by facilitating removal of inflammatory CC chemokines. In D6-deficient mice, otherwise innocuous cutaneous inflammatory stimuli induce a grossly exaggerated inflammatory response that bears many similarities to human psoriasis. In the present study, we have used transcriptomic approaches to define the molecular make up of this response. The data presented highlight potential roles for a number of cytokines in initiating and maintaining the psoriasis-like pathology. Most compellingly, we provide data indicating a key role for the type I interferon pathway in the emergence of this pathology. Neutralizing antibodies to type I interferons are able to ameliorate the psoriasis-like pathology, confirming a role in its development. Comparison of transcriptional data generated from this mouse model with equivalent data obtained from human psoriasis further demonstrates the strong similarities between the experimental and clinical systems. As such, the transcriptional data obtained in this preclinical model provide insights into the cytokine network active in exaggerated inflammatory responses and offer an excellent tool to evaluate the efficacy of compounds designed to therapeutically interfere with inflammatory processes

Taking Uncertainty Seriously: From Permissive Regulation to Preventative Design in Environmental Decision Making

This paper contrasts two paradigms of environmental regulatory decision making, permissive regulation and preventative design, with respect to their treatment of scientific and legal uncertainty and the allocation of legal standards and burdens of proof. Permissive regulation, which is the predominant approach in Canada, suffers two types of statistical errors. A type I error occurs when, for example, a pollution control device is unjustly imposed on an industry. A type II error occurs when no action is taken to control an industry when, in fact, damage is taking place. Concern to prevent type I errors often leads to type II errors. Attempts to resolve these problems through incremental changes in legislation and policy have generally failed. This article illustrates the scientific and regulatory problems associated with \u27permissive regulation through an analysis of environmental common law, legislation, and regulation. Protection of environmental quality requires regulatory decision making rooted in the principles of precautionary, preventative action that tends to minimize costly type II errors. With the preventative design approach now being used in several jurisdictions, the regulatory burden of proving harm is shifted from regulators to the polluters who must demonstrate safety. European and American initiatives as well as international agreements illustrate the historical development and implementation of this preventative design perspective. This article suggests that Canadian legislation and regulations be written with this approach