Potential markets for a satellite-based mobile communications system

The objective of the study was to define the market needs for improved land mobile communications systems. Within the context of this objective, the following goals were set: (1) characterize the present mobile communications industry; (2) determine the market for an improved system for mobile communications; and (3) define the system requirements as seen from the potential customer's viewpoint. The scope of the study was defined by the following parameters: (1) markets were confined to U.S. and Canada; (2) range of operation generally exceeded 20 miles, but this was not restrictive; (3) the classes of potential users considered included all private sector users, and non-military public sector users; (4) the time span examined was 1975 to 1985; and (5) highly localized users were generally excluded - e.g., taxicabs, and local paging

Alpine topography of the Gamburtsev Subglacial Mountains, Antarctica, mapped from ice sheet surface morphology

Landscapes buried beneath the Antarctic Ice Sheet preserve information about the geologic and geomorphic evolution of the continent both before and during the wide-scale glaciation that began roughly 34×106 years ago. Since the inception of this ice sheet, some areas have remained cold-based and non-erosive, preserving ancient landscapes remarkably intact. The Gamburtsev Subglacial Mountains in central East Antarctica are one such landscape, maintaining evidence of tectonic, fluvial and glacial controls on their distinctly alpine morphology. The central Gamburtsev Mountains have previously been surveyed using airborne ice-penetrating radar; however, many questions remain as to their evolution and their influence on the East Antarctic Ice Sheet, including where in the region to drill for a 1.5×106 year-long “oldest-ice” core. Here, we derive new maps of the planform geometry of the Gamburtsev Subglacial Mountains from satellite remote sensing datasets of the ice sheet surface, based on the relationship between bed roughness and ice surface morphology. Automated and manual approaches to mapping were tested and validated against existing radar data and elevation models. Manual mapping was more effective than automated approaches at reproducing bed features observed in radar data, but a hybrid approach is suggested for future work. The maps produced here show the detail of mountain ridges and valleys on wavelengths significantly smaller than the spacing of existing radar flightlines, and mapping has extended well beyond the confines of existing radar surveys. Morphometric analysis of the mapped landscape reveals that it constitutes a preserved (>34 Ma) dendritic valley network, with some evidence for modification by topographically confined glaciation prior to ice sheet inception. The planform geometry of the landscape is a significant control on locations of basal melting, subglacial hydrological flows and the stability of the ice sheet over time, so the maps presented here may help to guide decisions about where to search for oldest ice

Seasonal evolution of supraglacial lakes on an East Antarctic outlet glacier

Supraglacial lakes are known to influence ice melt and ice flow on the Greenland ice sheet and potentially cause ice shelf disintegration on the Antarctic Peninsula. In East Antarctica, however, our understanding of their behavior and impact is more limited. Using >150 optical satellite images and meteorological records from 2000 to 2013, we provide the first multiyear analysis of lake evolution on Langhovde Glacier, Dronning Maud Land (69°11′S, 39°32′E). We mapped 7990 lakes and 855 surface channels up to 18.1 km inland (~670 m above sea level) from the grounding line and document three pathways of lake demise: (i) refreezing, (ii) drainage to the englacial/subglacial environment (on the floating ice), and (iii) overflow into surface channels (on both the floating and grounded ice). The parallels between these mechanisms, and those observed on Greenland and the Antarctic Peninsula, suggest that lakes may similarly affect rates and patterns of ice melt, ice flow, and ice shelf disintegration in East Antarctica

Bias spectroscopy and simultaneous SET charge state detection of Si:P double dots

We report a detailed study of low-temperature (mK) transport properties of a silicon double-dot system fabricated by phosphorous ion implantation. The device under study consists of two phosphorous nanoscale islands doped to above the metal-insulator transition, separated from each other and the source and drain reservoirs by nominally undoped (intrinsic) silicon tunnel barriers. Metallic control gates, together with an Al-AlOx single-electron transistor, were positioned on the substrate surface, capacitively coupled to the buried dots. The individual double-dot charge states were probed using source-drain bias spectroscopy combined with non-invasive SET charge sensing. The system was measured in linear (VSD = 0) and non-linear (VSD 0) regimes allowing calculations of the relevant capacitances. Simultaneous detection using both SET sensing and source-drain current measurements was demonstrated, providing a valuable combination for the analysis of the system. Evolution of the triple points with applied bias was observed using both charge and current sensing. Coulomb diamonds, showing the interplay between the Coulomb charging effects of the two dots, were measured using simultaneous detection and compared with numerical simulations.Comment: 7 pages, 6 figure

Non-communicable diseases in emergencies: a call to action

Recent years have demonstrated the devastating health consequences of complex emergencies and natural disasters and thereby highlighted the importance of comprehensive and collaborative approaches to humanitarian responses and risk reduction. Simultaneously, noncommunicable diseases are now recognised as a real and growing threat to population health and development; a threat that is magnified by and during emergencies. Noncommunicable diseases, however, continue to receive little attention from humanitarian organisations in the acute phase of disaster and emergency response. This paper calls on all sectors to recognise and address the specific health challenges posed by noncommunicable diseases in emergencies and disaster situations. This publication aims to highlight the need for: • Increased research on morbidity and mortality patterns due to noncommunicable diseases during and following emergencies; • Raised awareness through greater advocacy for the issue and challenges of noncommunicable diseases during and following emergencies; • Incorporation of noncommunicable diseases into existing emergency-related policies, standards, and resources; • Development of technical guidelines on the clinical management of noncommunicable diseases in emergencies; • Greater integration and coordination in health service provision during and following emergencies; • Integrating noncommunicable diseases into practical and academic training of emergency workers and emergency-response coordinators

Biosynthesis of selenate reductase in <i>Salmonella enterica</i>:critical roles for the signal peptide and DmsD

Salmonella enterica serovar Typhimurium is a Gram-negative bacterium with a flexible respiratory capability. Under anaerobic conditions, S. enterica can utilize a range of terminal electron acceptors, including selenate, to sustain respiratory electron transport. The S. enterica selenate reductase is a membrane-bound enzyme encoded by the ynfEFGH-dmsD operon. The active enzyme is predicted to comprise at least three subunits where YnfE is a molybdenum-containing catalytic subunit. The YnfE protein is synthesized with an N-terminal twin-arginine signal peptide and biosynthesis of the enzyme is coordinated by a signal peptide binding chaperone called DmsD. In this work, the interaction between S. enterica DmsD and the YnfE signal peptide has been studied by chemical crosslinking. These experiments were complemented by genetic approaches, which identified the DmsD binding epitope within the YnfE signal peptide. YnfE signal peptide residues L24 and A28 were shown to be important for assembly of an active selenate reductase. Conversely, a random genetic screen identified the DmsD V16 residue as being important for signal peptide recognition and selenate reductase assembly

Absorbent products for urinary/faecal incontinence: a comparative evaluation of key product designs

Background: The UK health service, nursing homes and public spend around £94 million per year on incontinence pads (absorbent products) to contain urine and/or faeces, but the research base for making informed choices between different product designs is very weak.Objectives: The aim of this trial was to compare the performance and cost-effectiveness of the key absorbent product designs to provide a more solid basis for guiding selection and purchase.A further aim was to carry out the first stage in the development of a quality of life instrument for measuring the impact of absorbent product use on users' lives.Design: The work involved three clinical trials focusing on the three biggest market sectors. Each trial had a similar crossover design in which each participant tested all products within their group in random order.Settings, participants and methods: In Trial 1, 85 women with light urinary incontinence living in the community tested three products from each of the four design categories available (total of 12 test products): disposable inserts (pads); menstrual pads; washable pants with integral pad; and washable inserts. In Trial 2a, 85 moderate/heavily incontinent adults (urinary or urinary/faecal) living in the community (49 men and 36 women) tested three (or two) products from each of the five design categories available (total of 14 test products): disposable inserts (with mesh pants); disposable diapers (nappies); disposable pull-ups (similar to toddlers' trainer pants); disposable T-shaped diapers (nappies with waist-band); and washable diapers. All products were provided in a daytime and a (mostly more absorbent) night-time variant. In these first two trials, the test products were selected on the basis of data from pilot studies. In Trial 2b, 100 moderate/heavily incontinent adults (urinary or urinary/faecal) living in 10 nursing homes (27 men and 73 women) evaluated one product from each of the four disposable design categories from Trial 2a. Products were selected on the basis of product performance in Trial 2a and, again, daytime and night-time variants were provided. The first phase of work to develop a quality of life tool for measuring the impact of using different pad designs was carried out by interviewing participants from Trials 1 and 2a.Outcome measures: Product performance was characterised using validated questionnaires, which asked the participants (in Trials 1 and 2a) or carers (all participants in Trial 2b, except for the few who could report for themselves) to evaluate various aspects of pad performance (leakage, ease of putting on, discreetness, etc.) using a five-point scale (very good–very poor) at the end of the week (or 2 weeks for Trial 2b) of product testing. In addition, participants/carers were asked to save individual used pads in bags for weighing and to indicate the severity of any leakage from them on a three-point scale (none, a little, a lot). These data were used to determine differences in leakage performance. Numbers of laundry items and pads used were recorded to estimate costs, and skin health changes were recorded by the participant or by the researchers (Trial 2b). At the end of testing, participants were interviewed and ranked their preferences (with and without costs), stated the acceptability of each design (highly acceptable–totally unacceptable) and recorded their overall opinion on a visual analogue scale (VAS) of 0–100 points (worst design–best design). This VAS score was used with product costs to estimate cost-effectiveness. In addition, a timed pad changing exercise was conducted with 10 women from Trial 2b to determine any differences between product designs.Results: Results presented are for statistically and clinically significant findings.<br/

Extensive and anomalous grounding line retreat at Vanderford Glacier, Vincennes Bay, Wilkes Land, East Antarctica

Wilkes Land, East Antarctica, has been losing mass at an accelerating rate over recent decades in response to enhanced oceanic forcing. Overlying the Aurora Subglacial Basin, it has been referred to as the ‘weak underbelly’ of the East Antarctic Ice Sheet and is drained by several major outlet glaciers. Despite their potential importance, few of these glaciers have been studied in detail. This includes the six outlet glaciers which drain into Vincennes Bay, a region recently discovered to have the warmest intrusions of modified Circumpolar Deep Water (mCDW) ever recorded in East Antarctica. Here, we use remotely sensed optical imagery, differential satellite aperture radar interferometry (DInSAR) and datasets of ice surface velocity, ice surface elevation and grounding line position, to investigate ice dynamics between 1963 and 2022. Decadal trends in frontal position are observed across the Vincennes Bay outlet glaciers, potentially correlated to variations in sea ice production. Ice surface velocities were generally stable between 2000 and 2021, with some fluctuations measured across the grounding line of Bond East Glacier. Changes in ice surface elevation were spatially variable, but a clear and consistent thinning trend was measured at Vanderford Glacier between 2003 and 2020. Enhanced rates of ice thinning were seen across each of the Vanderford, Adams, Anzac, and Underwood Glaciers between 2017 and 2020. Most importantly, our results confirm extensive grounding line retreat at Vanderford Glacier, measured at 18.6 km between 1996 and 2020. Such rapid grounding line retreat (0.8 km yr-1) is consistent with the notion that warm mCDW is able to access deep cavities formed below the Vanderford Ice Shelf, driving high rates of basal melting. With a retrograde slope observed inland along the Vanderford Trench, such oceanic forcing may have significant implications for the future stability of Vanderford Glacier