798 research outputs found
Ariel - Volume 8 Number 3
Executive Editor
James W. Lockard, Jr.
Business Manager
Neeraj K. Kanwal
University News
Richard J . Perry
World News
Doug Hiller
Opinions
Elizabeth A. McGuire
Features
Patrick P. Sokas
Sports Desk
Shahab S. Minassian
Managing Editor
Edward H. Jasper
Managing Associate
Brenda Peterson
Photography Editor
Robert D. Lehman. Jr.
Graphics
Christine M. Kuhnl
Ariel - Volume 8 Number 2
Executive Editor
James W. Lockard , Jr.
Issue Editor
Doug Hiller
Business Manager
Neeraj K. Kanwal
University News
Richard J. Perry
World News
Doug Hiller
Opinions
Elizabeth A. McGuire
Features
Patrick P. Sokas
Sports Desk
Shahab S. Minassian
Managing Editor
Edward H. Jasper
Managing Associate
Brenda Peterson
Photography Editor
Robert D. Lehman, Jr.
Graphics
Christine M. Kuhnl
Professional Seminar: Valuing a One-Credit Course Through the Lens of Doctoral Students
Professional seminar for doctoral students at a Research I University is a 1-credit course, 2 below the conventional courses. However, the course content covers at least 3 years’ worth of experiences, knowledge, and processes compressed into a single school year. The course typically extends over 16 weeks and 24 actual contact hours with 1 professor to 7 students on average. Assignments expose students to professional jobs in academia, resources available on campus, grant writing procedures, and facilitate the trajectory and purpose of the doctoral process. The purpose of this study is to investigate doctoral students’ narratives on the value they hold for seminar. Findings indicate an overarching theme of value among 5 categories: opportunities, cohort, departmental support, overcoming obstacles, and vested interest
Stellar Stalling:the view from asteroseismology
Asteroseismology, the study of intrinsic oscillations in stars, can reveal fundamental properties of cool stars critical in our understanding of stellar rotational evolution. Through space missions such as Kepler and TESS, asteroseismology has seen a surge of new data and research in the past decade. These data have contributed to important results in the field of stellar braking particularly for F, G and K stars, thanks to estimates of stellar age for rotating field stars, and the measurement of stellar rotation through oscillation spectra as important comparisons for estimates from star-spots.
In this talk, I will provide an introduction to asteroseismology how it can provide important results for your research. This will be followed by a breakdown of how asteroseismologists have used these techniques to establish the presence of weakened magnetic braking on the main sequence using asteroseismic data, and what we should be looking forward to from these techniques with the TESS mission
How low can SUSY go? Matching, monojets and compressed spectra
If supersymmetry (SUSY) has a compressed spectrum then the current mass
limits from the LHC can be drastically reduced. We consider a possible 'worst
case' scenario where the gluino and/or squarks are degenerate with the lightest
SUSY particle (LSP). The most sensitive searches for these compressed spectra
are via the final state LSPs recoiling against initial state radiation (ISR).
Therefore it is vital that the ISR is understood and possible uncertainties in
the predictions are evaluated. We use both MLM (with Pythia 6) and CKKW- L
(with Pythia 8) matching and vary matching scales and parton shower properties
to accurately determine the theoretical uncertainties in the kinematic
distributions. All current LHC SUSY and monojet analyses are employed and we
find the most constraining limits come from the CMS Razor and CMS monojet
searches. For a scenario of squarks degenerate with the LSP and decoupled
gluinos we find GeV. For gluinos degenerate with the LSP
and decoupled squarks, GeV. For equal mass squarks and
gluinos degenerate with the LSP, GeV.Comment: References added, version submitted to ep
Histopathological screening of Pontogammarus robustoides (Amphipoda), an invader on route to the United Kingdom
Biological invasions may act as conduits for pathogen introduction. To determine which invasive non-native species pose the biggest threat, we must first determine the symbionts (pathogens, parasites, commensals, mutualists) they carry, via pathological surveys that can be conducted in multiple ways (i.e., molecular, pathological, and histological). Whole animal histopathology allows for the observation of pathogenic agents (virus to Metazoa), based on their pathological effect upon host tissue. Where the technique cannot accurately predict pathogen taxonomy, it does highlight pathogen groups of importance. This study provides a histopathological survey of Pontogammarus robustoides (invasive amphipod in Europe) as a baseline for symbiont groups that may translocate to other areas/hosts in future invasions
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and relieving pain. Unlike typical opioid narcotics, KOR agonists do not produce euphoria or lead to respiratory suppression or overdose. However, they do produce dysphoria and sedation, side effects that have precluded their clinical development as therapeutics. KOR signaling can be fine-tuned to preferentially activate certain pathways over others, such that agonists can bias signaling so that the receptor signals through G proteins rather than other effectors such as βarrestin2. We evaluated a newly developed G protein signaling–biased KOR agonist in preclinical models of pain, pruritis, sedation, dopamine regulation, and dysphoria. We found that triazole 1.1 retained the antinociceptive and antipruritic efficacies of a conventional KOR agonist, yet it did not induce sedation or reductions in dopamine release in mice, nor did it produce dysphoria as determined by intracranial self-stimulation in rats. These data demonstrated that biased agonists may be used to segregate physiological responses downstream of the receptor. Moreover, the findings suggest that biased KOR agonists may present a means to treat pain and intractable itch without the side effects of dysphoria and sedation and with reduced abuse potential
The HIPASS Catalogue - II. Completeness, Reliability, and Parameter Accuracy
The HI Parkes All Sky Survey (HIPASS) is a blind extragalactic HI 21-cm
emission line survey covering the whole southern sky from declination -90 to
+25. The HIPASS catalogue (HICAT), containing 4315 HI-selected galaxies from
the region south of declination +2, is presented in Meyer et al. (2004a, Paper
I). This paper describes in detail the completeness and reliability of HICAT,
which are calculated from the recovery rate of synthetic sources and follow-up
observations, respectively. HICAT is found to be 99 per cent complete at a peak
flux of 84 mJy and an integrated flux of 9.4 Jy km/s. The overall reliability
is 95 per cent, but rises to 99 per cent for sources with peak fluxes >58 mJy
or integrated flux > 8.2 Jy km/s. Expressions are derived for the uncertainties
on the most important HICAT parameters: peak flux, integrated flux, velocity
width, and recessional velocity. The errors on HICAT parameters are dominated
by the noise in the HIPASS data, rather than by the parametrization procedure.Comment: Accepted for publication in MNRAS. 12 pages, 11 figures. Paper with
higher resolution figures can be downloaded from http://hipass.aus-vo.or
Gelation Landscape Engineering Using a Multi-Reaction Supramolecular Hydrogelator System
Simultaneous control of the kinetics and
thermodynamics of two different types of covalent
chemistry allows pathway selectivity in the formation of
hydrogelating molecules from a complex reaction network.
This can lead to a range of hydrogel materials with vastly
different properties, starting from a set of simple starting
compounds and reaction conditions. Chemical reaction
between a trialdehyde and the tuberculosis drug isoniazid
can form one, two, or three hydrazone connectivity
products, meaning kinetic gelation pathways can be
addressed. Simultaneously, thermodynamics control the
formation of either a keto or an enol tautomer of the
products, again resulting in vastly different materials.
Overall, this shows that careful navigation of a reaction
landscape using both kinetic and thermodynamic
selectivity can be used to control material selection from
a complex reaction network
The Effect of Dapagliflozin on Albuminuria in DECLARE-TIMI 58
OBJECTIVE Sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve albuminuria in patients with high cardiorenal risk. We report albuminuria change in the Dapagliflozin Effect on Cardiovascular Events (DECLARE-TIMI 58) cardiovascular outcome trial, which included populations with lower cardiorenal risk. RESEARCH DESIGN AND METHODS DECLARE-TIMI 58 randomized 17,160 patients with type 2 diabetes, creatinine clearance >60 mL/min, and either atherosclerotic cardiovascular disease (CVD; 40.6%) or risk-factors for CVD (59.4%) to dapagliflozin or placebo. Urinary albumin-to-creatinine ratio (UACR) was tested at baseline, 6 months, 12 months, and yearly thereafter. The change in UACR over time was measured as a continuous and categorical variable (15 to = 30 to 300 mg/g) by treatment arm. The composite cardiorenal outcome was a >= 40% sustained decline in the estimated glomerular filtration rate (eGFR) to 15 to 300 mg/g. Measured as a continuous variable, UACR improved from baseline to 4.0 years with dapagliflozin, compared with placebo, across all UACR and eGFR categories (all P = 1 category improvement in UACR was more common in dapagliflozin versus placebo (hazard ratio 1.45 [95% CI 1.35-1.56], P = 30 mg/g (P < 0.0125, P-interaction = 0.033), and the renal-specific outcome was reduced for all UACR subgroups (P < 0.05, P-interaction = 0.480). CONCLUSIONS In DECLARE-TIMI 58, dapagliflozin demonstrated a favorable effect on UACR and renal-specific outcome across baseline UACR categories, including patients with normal albumin excretion. The results suggest a role for SGLT2i also in the primary prevention of diabetic kidney disease
- …