19 research outputs found

    Public Accounting Firm Characteristics: Their Importance To Students And Discussion By Recruiters

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    This was a survey-based study of the importance that students attach to various employer qualities and the extent that public accounting recruiters discuss such qualities. Attitudinal differences among students with different academic credentials and differences in the structure of recruiting interviews by various sized public accounting firms were the focus of the study. The data were collected from 106 accounting students and 63 recruiters. Before the beginning of the fall campus interviewing period, students rated the importance of 36 employer characteristics and recruiters reported to what extent they discussed the characteristics during the recruiting process. In general, no differences were noted among students of varying academic credentials. Significant differences, however, were noted in the level of discussion by recruiters from firms of varying size. The extent that recruiters from the various sized firms discussed the characteristics was compared with the student perceived importance. The extent that the national firm recruiters discussed the characteristics most closely matched the student importance ratings, and the discussion by the local firm recruiters least matched the student ratings

    INTERRELATIONS OF LAW AND ECONOMICS: THE CASE OF STREAM POLLUTION

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    Tip60 Is Required for DNA Interstrand Cross-link Repair in the Fanconi Anemia Pathway*

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    The disease Fanconi anemia is a genome instability syndrome characterized by cellular sensitivity to DNA interstrand cross-linking agents, manifest by decreased cellular survival and chromosomal aberrations after such treatment. There are at least 13 proteins acting in the pathway, with the FANCD2 protein apparently functioning as a late term effecter in the maintenance of genome stability. We find that the chromatin remodeling protein, Tip60, interacts directly with the FANCD2 protein in a yeast two-hybrid system. This interaction has been confirmed by co-immunoprecipitation and co-localization using both endogenous and epitope-tagged FANCD2 and Tip60 from human cells. The observation of decreased cellular survival after exposure to mitomycin C in normal fibroblasts depleted for Tip60 indicates a direct function in interstrand cross-link repair. The coincident function of Tip60 and FANCD2 in one pathway is supported by the finding that depletion of Tip60 in Fanconi anemia cells does not increase sensitivity to DNA cross-links. However, depletion of Tip60 did not reduce monoubiquitination of FANCD2 or its localization to nuclear foci following DNA damage. The observations indicate that Fanconi anemia proteins act in concert with chromatin remodeling functions to maintain genome stability after DNA cross-link damage
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