Improving Drug Safety: The Importance of Postmarking Drug Surveillance

Improved postmarketing surveillance system may reduce the number of adverse reactions to prescription drugs that under the current system continue to rise as the number of prescriptions written in the U.S. rises

Preparing for an Aging Nation: The Need for Academic Geriatricians

According to the author of this issue brief, a strong commitment by the government to a regular stream of financial support for geriatrics would encourage medical centers to establish or expand programs, enhance their ability to attract funds from private sources, and ultimately produce a sufficient number of academic geriatricians. Given the impending retirement of the baby boom generation, this process should begin as soon as possible. This issue brief highlights the critical need for academic geriatricians and presents a realistic proposal to help address the problem

Walk to a Healthy Future

Proposes a new national commitment to walking and formation of walking partnerships and clubs to fight the epidemic of overweight Americans

Quenched Chiral Perturbation Theory for Baryons

We develop quenched chiral perturbation theory for baryons using the graded-symmetry formalism of Bernard and Golterman and calculate non-analytic contributions to the baryon masses coming from quenched chiral loops. The usual term proportional to $m_{q}^{3/2}$ is substantially altered due to the cancellation of diagrams with internal quark loops. In addition, the $\eta'$ ``hairpin'' vertex leads to a new correction, proportional to $m_{q}^{1/2}$. We compare our results to numerical lattice data and use them to estimate the size of the quenching error in the octet baryon masses.Comment: 7 pages (An abridged version of this note will appear in the proceedings of Lattice'93. Latex + 14 postscript files, bundled using uufiles. Needs psfig.) UW/PT-93-0

Challenging empowerment: AIDS-affected southern African children and the need for a multi-level relational approach

Critics of empowerment have highlighted the concept's mutability, focus on individual transformation, one-dimensionality and challenges of operationalisation. Relating these critiques to children's empowerment raises new challenges. Drawing on scholarship on children's subjecthood and exercise of power, alongside empirical research with children affected by AIDS, I argue that empowerment envisaged as individual self-transformation and increased capacity to act independently offers little basis for progressive change. Rather it is essential to adopt a relational approach that recognises the need to transform power relationships at multiple levels. This analysis has implications for our wider understanding of empowerment in the 21st century. © The Author(s) 2013.This research was funded by DFID

Characterizations of a KHz Pulsed Laser Detection System

A KHz Pulsed Laser Detection System was developed employing the concept of charge integration with an electrometer, in the NASA Goddard Space Flight Center, Code 618 Calibration Lab for the purpose of using the pulsed lasers for radiometric calibration. Comparing with traditional trans-impedance (current-voltage conversion) detection systems, the prototype of this system consists of a UV-Enhanced Si detector head, a computer controlled shutter system and a synchronized electrometer. The preliminary characterization work employs light sources running in either CW or pulsed mode. We believe this system is able to overcome the saturation issue when a traditional trans-impedance detection system is used with the pulsed laser light source, especially with high peak-power pulsed lasers operating at kilohertz repetition rates (e.g. Ekspla laser or KHz OPO). The charge integration mechanism is also expected to improve the stability of measurements for a pulsed laser light source overcoming the issue of peak-to-peak stability. We will present the system characterizations including signal-to-noise ratio and uncertainty analysis and compare results against traditional trans-impedance detection systems

Embodied learning: Responding to AIDS in Lesotho's education sector

This is an Author's Accepted Manuscript of an article published in Children's Geographies, 7(1), 2009. Copyright @ 2009 Taylor & Francis, available online at: http://www.tandfonline.com/doi/abs/10.1080/14733280802630981.In contrast to pre-colonial practices, education in Lesotho's formal school system has historically assumed a Cartesian separation of mind and body, the disciplining of students' bodies serving principally to facilitate cognitive learning. Lesotho has among the highest HIV-prevalence rates worldwide, and AIDS has both direct and indirect impacts on the bodies of many children. Thus, students' bodies can no longer be taken for granted but present a challenge for education. Schools are increasingly seen as a key point of intervention to reduce young people's risk of contracting the disease and also to assist them to cope with its consequences: there is growing recognition that such goals require more than cognitive learning. The approaches adopted, however, range from those that posit a linear and causal relationship between knowledge, attitudes and practices (so-called ‘KAP’ approaches, in which the role of schools is principally to inculcate the pre-requisite knowledge) to ‘life skills programmes’ that advocate a more embodied learning practice in schools. Based on interviews with policy-makers and practitioners and a variety of documentary sources, this paper examines a series of school-based AIDS interventions, arguing that they represent a less radical departure from ‘education for the mind’ than might appear to be the case. The paper concludes that most interventions serve to cast on children responsibility for averting a social risk, and to ‘normalise’ aberrant children's bodies to ensure they conform to what the cognitively-oriented education system expects

The hookworm Ancylostoma ceylanicum: an emerging public health risk in Australian tropical rainforests and Indigenous communities

Ancylostoma ceylanicum is the common hookworm of domestic dogs and cats throughout Asia, and is an emerging but little understood public health risk in tropical northern Australia. We investigated the prevalence of A. ceylanicum in soil and free-ranging domestic dogs at six rainforest locations in Far North Queensland that are Indigenous Australian communities and popular tourist attractions within the Wet Tropics World Heritage Area. By combining PCR-based techniques with traditional methods of hookworm species identification, we found the prevalence of hookworm in Indigenous community dogs was high (96.3% and 91.9% from necropsy and faecal samples, respectively). The majority of these infections were A. caninum. We also observed, for the first time, the presence of A. ceylanicum infection in domestic dogs (21.7%) and soil (55.6%) in an Indigenous community. A. ceylanicum was present in soil samples from two out of the three popular tourist locations sampled. Our results contribute to the understanding of dogs as a public health risk to Indigenous communities and tourists in the Wet Tropics. Dog health needs to be more fully addressed as part of the Australian Government's commitments to "closing the gap" in chronic disease between Indigenous and other Australians, and encouraging tourism in similar locations

Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes

Both Rb and p130 are required for the recruitment of heterochromatin proteins that mediate silencing of proliferation genes in adult cardiac myocytes