On board sampling of the rockfish and lingcod commerical passenger fishing vessel industry in northern and central California, May 1987 to December 1991

From May 1987 to June 1990 and from August to December 1991 Fishery Technicians sampled catches on board 690 Commercial Passenger Fishing Vessel (CPFV) trips targeting rockfish and lingcod from the general port areas of Fort Bragg, Bodega Bay, San Francisco, Monterey, and Morro Bay. Data are presented for species composition by port area, year, and month, for catch-per-unit-effort, mean length, and length frequency of lingcod and the 18 most frequently observed rockfish species, and for trends in fishing effort related to fishing time, depth, and distance from port. Total catch estimates are presented based on unadjusted logbook records, logbook records adjusted by sampling data and compliance rates, and effort data from a marine recreational fishing statistics survey. Average catch of kept fish per angler day was 11.8 and average catch of kept fish per angler hour was 3.7. A trend of an increasing frequency of trips to deep (>40 fm) locations was observed in the Bodega Bay, San Francisco, and Monterey areas from 1988 to 1990-91. No trend was evident relative to trip frequency and distance from port. A total of 74 species was observed caught during the study. Rockfishes comprised 88.5% to 97.9% by number of the observed catch by port area. The five most frequently observed species were chilipepper, blue, yellowtail, and widow rockfishes, and bocaccio, with lingcod ranking seventh. In general, mean length and catch-per-angler-hour of sport fishes caught by CPFV anglers varied considerably and did not show steady declines during the study period. However, port-specific areas of major concern were identified for chilipepper, lingcod, and black rockfish, and to a lesser extent brown, canary, vermilion, yelloweye, olive, and widow rockfish. These areas of concern included steadily declining catch rate, steadily declining mean length, and a high percentage of sexually immature fish in the sampled-catch. Recent sampling of the commercial hook-and-line fishery in northern and central California indicated that most species of rockfishes taken by CPFV anglers are also harvested commercially. (261pp.

Comparing Two Methods for Quantifying Soil-borne Entomophaga maimaiga Resting Spores

To improve usability of methods for quantifying environmentally persistent entomophthoralean resting spores in soil, we modified and tested two methods using resting spores (azygospores) of the gypsy moth pathogen Entomophaga maimaiga. Both methods were effective for recovering resting spores at concentrations \u3e100 resting spores/g dry soil. While a modification of a method originally described by Weseloh and Andreadis (2002) recovered more resting spores than a modified method based on Percoll density gradients, the ability to estimate true densities from counts was similar for both methods. Regression equations are provided for predicting true resting spore densities from counts, with R 2 values for both methods P0.90

Performance of an environmental test to detect Mycobacterium bovis infection in badger social groups

A study by Courtenay and others (2006) demonstrated that the probability of detecting Mycobacterium bovis by PCR in soil samples from the spoil heaps of main badger setts correlated with the prevalence of excretion (infectiousness) of captured badgers belonging to the social group. It has been proposed that such a test could be used to target badger culling to setts containing infectious animals (Anon 2007). This short communication discusses the issues surrounding this concept, with the intention of dispelling any misconceptions among relevant stakeholders (farmers, policy makers and conservationists)

The Grizzly, November 3, 1978

Task Force Proposes Curricular Revisions: Faculty Discusses Broad Academic Changes • Computer Programs To Be Studied • Reed This Message • Liberal Education for a Modern World • Letters to the Editor • Campus Committees Graded • Springsteen Revisited • Halloween Horrors! • Annual Messiah Rehearsal • French Club Wined and Dined • GM: Looking Good For \u2779 • Soccer Trounces Widener • Founders\u27 Convocation • Harriers Cap 12-1 Season • Mermaids Anticipate Slick Season • Hockey J. V.s With No Losses • Zetans Take Intramural Football Championship • News in Brief: Egdon Heath to Rock T. G.; Forum Presents Workshop, Performance; Ursinus Appoints Band Directorhttps://digitalcommons.ursinus.edu/grizzlynews/1005/thumbnail.jp

Book Review Roundtable: Kathryn E. Stoner’s Russia Resurrected: Its Power and Purpose in a New Global Order and James Reilly’s Orchestration: China’s Economic Statecraft Across Asia and Europe

This double book review roundtable examines the drivers and international influence of Russia and China. It features Kathryn Stoner’s Russia Resurrected: Its Power and Purpose in a New Global Order and James Reilly’s Orchestration: China’s Economic Statecraft Across Asia and Europe

Removing Orbital Debris with Lasers

Orbital debris in low Earth orbit (LEO) are now sufficiently dense that the use of LEO space is threatened by runaway collisional cascading. A problem predicted more than thirty years ago, the threat from debris larger than about 1 cm demands serious attention. A promising proposed solution uses a high power pulsed laser system on the Earth to make plasma jets on the objects, slowing them slightly, and causing them to re-enter and burn up in the atmosphere. In this paper, we reassess this approach in light of recent advances in low-cost, light-weight modular design for large mirrors, calculations of laser-induced orbit changes and in design of repetitive, multi-kilojoule lasers, that build on inertial fusion research. These advances now suggest that laser orbital debris removal (LODR) is the most cost-effective way to mitigate the debris problem. No other solutions have been proposed that address the whole problem of large and small debris. A LODR system will have multiple uses beyond debris removal. International cooperation will be essential for building and operating such a system.Comment: 37 pages, 15 figures, in preparation for submission to Advances in Space Researc

Characterization of MSB Synapses in Dissociated Hippocampal Culture with Simultaneous Pre- and Postsynaptic Live Microscopy

Multisynaptic boutons (MSBs) are presynaptic boutons in contact with multiple postsynaptic partners. Although MSB synapses have been studied with static imaging techniques such as electron microscopy (EM), the dynamics of individual MSB synapses have not been directly evaluated. It is known that the number of MSB synapses increases with synaptogenesis and plasticity but the formation, behavior, and fate of individual MSB synapses remains largely unknown. To address this, we developed a means of live imaging MSB synapses to observe them directly over time. With time lapse confocal microscopy of GFP-filled dendrites in contact with VAMP2-DsRed-labeled boutons, we recorded both MSBs and their contacting spines hourly over 15 or more hours. Our live microscopy showed that, compared to spines contacting single synaptic boutons (SSBs), MSB-contacting spines exhibit elevated dynamic behavior. These results are consistent with the idea that MSBs serve as intermediates in synaptic development and plasticity

Impact of polygenic risk for coronary artery disease and cardiovascular medication burden on cognitive impairment in psychotic disorders

Background: Cognitive impairment is a core deficit across psychotic disorders, the causes and therapeutics of which remain unclear. Epidemiological observations have suggested associations between cognitive dysfunction in psychotic disorders and cardiovascular risk factors, but an underlying etiology has not been established. Methods: Neuropsychological performance using the Brief Assessment of Cognition in Schizophrenia (BACS) was assessed in 616 individuals of European ancestry (403 psychosis, 213 controls). Polygenic risk scores for coronary artery disease (PRSCAD) were quantified for each participant across 13 p-value thresholds (PT 0.5-5e-8). Cardiovascular and psychotropic medications were categorized for association analyses. Each PRSCAD was examined in relation to the BACS and the optimized PT was confirmed with five-fold cross-validation and independent validation. Functional enrichment analyses were used to identify biological mechanisms linked to PRSCAD-cognition associations. Multiple regression analyses examined PRSCAD under the optimal PT and medication burden in relation to the BACS composite and subtest scores. Results: Higher PRSCAD was associated with lower BACS composite scores (p = 0.001) in the psychosis group, primarily driven by the Verbal Memory subtest (p \u3c 0.001). Genes linked to multiple nervous system related processes and pathways were significantly enriched in PRSCAD. After controlling for PRSCAD, a greater number of cardiovascular medications was also correlated with worse BACS performance in patients with psychotic disorders (p = 0.029). Conclusions: Higher PRSCAD and taking more cardiovascular medications were both significantly associated with cognitive impairment in psychosis. These findings indicate that cardiovascular factors may increase the risk for cognitive dysfunction and related functional outcomes among individuals with psychotic disorders

The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release

<p>Objectives: Macrophages are central to the inflammatory processes driving rheumatoid arthritis (RA) synovitis. The molecular pathways that are induced in synovial macrophages and thereby promote RA disease pathology remain poorly understood.</p> <p>Methods: We used microarray to characterise the transcriptome of synovial fluid (SF) macrophages compared with matched peripheral blood monocytes from patients with RA (n=8).</p> <p>Results: Using in silico pathway mapping, we found that pathways downstream of the cholesterol activated liver X receptors (LXRs) and those associated with Toll-like receptor (TLR) signalling were upregulated in SF macrophages. Macrophage differentiation and tumour necrosis factor α promoted the expression of LXRα. Furthermore, in functional studies we demonstrated that activation of LXRs significantly augmented TLR-driven cytokine and chemokine secretion.</p> <p>Conclusions: The LXR pathway is the most upregulated pathway in RA synovial macrophages and activation of LXRs by ligands present within SF augments TLR-driven cytokine secretion. Since the natural agonists of LXRs arise from cholesterol metabolism, this provides a novel mechanism that can promote RA synovitis.</p&gt

Derivation of a Protein Risk Score for Cardiovascular Disease Among a Multiracial and Multiethnic HIV+ Cohort

Background Cardiovascular disease risk prediction models underestimate CVD risk in people living with HIV (PLWH). Our goal is to derive a risk score based on protein biomarkers that could be used to predict CVD in PLWH. Methods and Results In a matched case-control study, we analyzed normalized protein expression data for participants enrolled in 1 of 4 trials conducted by INSIGHT (International Network for Strategic Initiatives in Global HIV Trials). We used dimension reduction, variable selection and resampling methods, and multivariable conditional logistic regression models to determine candidate protein biomarkers and to generate a protein score for predicting CVD in PLWH. We internally validated our findings using bootstrap. A protein score that was derived from 8 proteins (including HGF [hepatocyte growth factor] and interleukin-6) was found to be associated with an increased risk of CVD after adjustment for CVD and HIV factors (odds ratio: 2.17 [95% CI: 1.58-2.99]). The protein score improved CVD prediction when compared with predicting CVD risk using the individual proteins that comprised the protein score. Individuals with a protein score above the median score were 3.10 (95% CI, 1.83-5.41) times more likely to develop CVD than those with a protein score below the median score. Conclusions A panel of blood biomarkers may help identify PLWH at a high risk for developing CVD. If validated, such a score could be used in conjunction with established factors to identify CVD at-risk individuals who might benefit from aggressive risk reduction, ultimately shedding light on CVD pathogenesis in PLWH