Modulation of Anthracycline Activity by a Range of Drug Carriers

Major advances in the treatment of leukaemia and lymphoma in the 1960s and 70s led to the euphoric belief that solid tumours would also yield to cytotoxic chemotherapy. Unfortunately this promise has remained largely unfulfilled. Many reasons are cited for this therapeutic failure, but it is generally accepted that drug resistance, either arising 'de novo' or aquired, is a major factor in this problem. The work detailed in this thesis looks at some possible methods of overcoming so-called pharmacological resistance' i.e. drug resistance based on an inability to deliver enough active drug to it's site of action

Parsing The Aggregation- and Photodegradation-Induced Effects of Rhodamine-Sensitized Tio2 and Zro2 Films

The impact of rhodamine aggregates on the photophysical properties of rhodamine dyes adsorbed to TiO2 were investigated using diffuse reflectance spectroscopy, steady-state fluorescence, and time-correlated single photon counting (TCSPC). Photocatalyzed de-alkylation of rhodamine dyes containing tertiary amine groups (5-ROX, R101, and RB) was observed on TiO2, which resulted in a ~50 nm hypsochromic shift. Therefore, concentration dependent diffuse reflectance spectra of R560/TiO2 samples, which contained primary amines, demonstrated the formation of H- and J-aggregates at the expense of the monomers. The formation of J-aggregates resulted in FRET between monomers and J-aggregates which yielded a bathochromic shifted fluorescence spectra as a function of increased dye concentration. Additionally, the J-aggregates were believed to be less fluorescent than the corresponding monomer, which, in addition to the presence of non-fluorescent H-aggregates, led to the quenched fluorescence. Time dependent fluorescent measurements established that electron injection to TiO2 from R560 occurred from both the monomer and J-aggregates, as lifetimes of each species on TiO2 were quenched relative to lifetimes on ZrO2

Proactive Stance of Social Workers and Physicians Toward Working with Individuals and Families Affected by Alcoholism

The University Archives has determined that this item is of continuing value to OSU's history.Presenter: Major John James Cassidy, Ph.D., Clinical Director, Tri Services Alcoholism Recovery Facility, United States Air Force, Tripler Army Medical Center, Honolulu, Hawaii - "Proactive Stance of Social Workers and Physicians Toward Working with Individuals and Families Affected by Alcoholism".The Ohio State University College of Social Wor

Eucharistic Liturgies Of The Church of England 1945-1980

This thesis examines the 'development of Anglican Eucharistic theology from 1945 to the present day as shown by the texts used for the Service of Holy Communion. Both authorized and unauthorized Orders as well as official publications are used as primary sources. In order to gain insight into the meanings of the texts, the debates of the Convocations, the National Assembly of the Church of England, and the General Synod which concerned the Orders are looked at very closely. The writings of the members of the Liturgical Commission of the General Synod are given special consideration. Also used are the various books and pamphlets which appeared as commentaries on the new Orders (often before authorization), especially where they reflected the position of the Catholic or Evangelical wings of the Church of England. The thesis shows how the Church of England progressed towards the Alternative Service Book and shows how the theological emphases of the Church of England moved, or were perceived to move. The conclusion is drawn that the Church of England has developed from the Book of Common Prayer, fixed in what might be called 'the Cranmerian position', to the Alternative Service Book which deliberately allows individuals to take part in the Eucharistic Mystery with varying insights into its theology

Report on Unicity Project

Report: 39 pp.; digital file.This report is an evaluation of a six-week communication project known as Project Unicity, Based on reports from the people involved, surveys and attitude studies, observation and discussion, the report attempts to show the background of the project; provide a descriptive analysis of what happened during the project;and demonstrate the usefulness and ability of a community-based television system

A pilot study of subjective well-being in colorectal cancer patients and their caregivers

Background: Traditional endpoints in oncology are based on measuring the tumor size and combining this with a time factor. Current studies with immunotherapy show that even when median survival is unaltered, a significant proportion of patients can achieve prolonged survival. Objective tumor response does not always mean “overall” improvement, especially if toxicity is harsh. Novel agents are significantly expensive, and it is therefore crucial to measure the impact on “quality” of life, in addition to “quantity”. Materials and methods: We studied the preferences and experiences of cancer patients and their caregivers, measuring subjective well-being (SWB) ratings, EQ5D descriptions and time trade-off preferences. Results: We studied 99 patients and 88 caregivers. Life satisfaction ratings were similar between the two groups, but daily mood was significantly lower in caregivers (P<0.1). Anxiety/depression affected SWB, while pain and mobility did not. Positive thoughts about health were associated with better daily moods in both groups, and stage IV cancer was associated with lower life satisfaction. Cancer in remission was associated with better daily moods, but, interestingly, not with patient life satisfaction. Patients with better daily mood and positive thoughts about family were less willing to “trade-off” life years. Conclusion: Caregivers are as anxious or depressed as patients, and report similar levels of life satisfaction but lower daily mood. A focus on SWB could provide a valid assessment of treatment benefit. Given the interesting results of this pilot study, we suggest a larger study should be conducted, measuring SWB over time

Exploring the Role of the Coach in Fostering Positive Youth Development within an Elite Sport Context

Youth sport is considered an ideal context to foster positive youth development (PYD) through an asset-building approach (Holt et al., 2017; Larson, 2000), yet researchers have questioned whether the pursuit of performance success within elite youth sport may hinder the pursuit of PYD (e.g., Fraser-Thomas & Strachan, 2015). Given extensive research underlining the important role of coaches in fostering PYD through sport (Holt et al., 2017 for review), research is needed to understand the experiences of elite youth sport coaches facilitating PYD within a performance-oriented environment (Fraser-Thomas & Strachan, 2015). Guided by Holt and colleagues (2017) model of PYD through sport, the purpose of this dissertation was to examine the role of the coach in fostering PYD within an elite youth sport context. In manuscript one, I drew upon autoethnographic research methods (Ellis & Bochner, 2000) to explore my experience coaching a Canadian elite minor hockey team, using a PYD approach to foster personal development and performance success. In manuscript two I used similar methodologies to examine my interactions with parents, and how these potentially fostered athlete PYD. Manuscript three explored coaches pursuit of PYD within elite youth sport more broadly through ethnographic research methods (Patton, 2005), as I acted as an assistant coach to four purposefully sampled teams for the duration of one season. Manuscript four examined the content of Hockey Canadas (2016) High Performance 1 coach education manual with specific attention to interpersonal coaching approaches that facilitate PYD. Collectively, findings indicate elite youth sport coaches were able to foster a PYD climate within a performance-oriented environment; however I/they experienced challenges and underlying tensions, particularly in relation to the coach-parent relationship, within a performance-oriented environment. Findings raise questions regarding the overall sport structure of AAA minor hockey in Canada, given the constant tension for coaches striving to attain performance success while balancing the goal of athletes PYD. My shared overall insights of my experiences may evoke other elite youth coaches to reflect on their coaching experiences and practices regarding fostering PYD through sport. Findings are further discussed in terms of contributions to the PYD literature, and future research directions