“A malignant, seething hatework”: an introduction to U.S. 21st century hardcore horror

The proliferation of U.S. horror films in the 21 st century has engendered an increase in critical and academic response which has almost exclusively focused on the conventions of mainstream horror cinema. That is, films sanctioned by classificatory bodies, released through mid to large production companies and exhibited via selected to wide theatrical releases. While academic work, drawing from film and cultural studies, has provided a much needed engagement with the popularity and themes of contemporary U.S. horror they have tended to exclude marginal or ‘hidden’ hardcore horror film examples. Therefore, this article will provide an introductory account of the films that form part of this horror sub-genre, from Eric Stanze’s Scrapbook (2000) through Fred Vogel’s August Underground trilogy (2001 – 2007) to Stephen Biro’s American Guinea Pig: Bouquet of Guts and Gore (2014). The article will briefly map out the criteria for a definition of hardcore horror before discussing some of its key examples. It is not my intention to simply interpret the films but to look at their ‘archaeology’ to account for the production practices, marketing and distribution strategies, and film reception. The importance of looking at hardcore horror in terms of an archaeology is to reintegrate its marginal status and cultural practices so that a wider examination of the cultural field of U.S. horror in terms of how it is made and experienced can be advanced

“A malignant, seething hatework”: an introduction to U.S. 21st century hardcore horror

The proliferation of U.S. horror films in the 21 st century has engendered an increase in critical and academic response which has almost exclusively focused on the conventions of mainstream horror cinema. That is, films sanctioned by classificatory bodies, released through mid to large production companies and exhibited via selected to wide theatrical releases. While academic work, drawing from film and cultural studies, has provided a much needed engagement with the popularity and themes of contemporary U.S. horror they have tended to exclude marginal or ‘hidden’ hardcore horror film examples. Therefore, this article will provide an introductory account of the films that form part of this horror sub-genre, from Eric Stanze’s Scrapbook (2000) through Fred Vogel’s August Underground trilogy (2001 – 2007) to Stephen Biro’s American Guinea Pig: Bouquet of Guts and Gore (2014). The article will briefly map out the criteria for a definition of hardcore horror before discussing some of its key examples. It is not my intention to simply interpret the films but to look at their ‘archaeology’ to account for the production practices, marketing and distribution strategies, and film reception. The importance of looking at hardcore horror in terms of an archaeology is to reintegrate its marginal status and cultural practices so that a wider examination of the cultural field of U.S. horror in terms of how it is made and experienced can be advanced

The role of rapid diagnostic tests in managing adults with pneumonia in low-resource settings

In well-resourced settings the systematic use of rapid diagnostics tests (e.g. pneumococcal urinary antigen test) that define the causal pathogen to direct therapy has not resulted in significantly improved outcomes in adults with pneumonia. The management of pneumonia in many low-resource settings is complicated by a substantial burden of tuberculosis and HIV-associated opportunistic infections, in addition to the usual spectrum of pathogens seen in well-resourced settings. Clinical features alone do not reliably distinguish between these different aetiologies and physicians often have to treat empirically. Given the limitations in diagnostic laboratory capability present in most low-resource settings, rapid and point-of-care diagnostic tests could become valuable tools to guide treatment decisions. Pneumococcal and Legionella urinary antigen tests are specific and moderately sensitive, but their utility in low-resource settings is uncertain. The Xpert MTB/RIF (Cepheid, USA) platform and rapid assays for urinary lipoarabinomannan can substantially speed up tuberculosis diagnosis; the current challenge is to translate this into earlier treatment and hopefully improve patient outcome. In HIV-infected patients, 1-3-β-D-glucan is a serum marker of Pneumocystis jirovecii infection with excellent sensitivity. Further studies are needed to assess the clinical utility and cost-effectiveness of these rapid diagnostic assays when they are incorporated into treatment algorithms.</p

The (Un)Christian Road Warrior: The Crisis of Religious Representation in The Book of Eli (2010)

In a recent review of The Book of Eli (JRF 14:1), Adam Porter has claimed that the movie is an “affirm[ation] of God and an exploration of “the way religion can be used, both positively and negatively”. In our article, we will argue instead that the role of religion in the movie is much more ambiguous than this and that the movie not only fails to resolve the differences between putative ‘positive’ and ‘negative’ uses of religion, but, indeed, is also based on a highly problematic understanding of the role of religion and particularly religious texts within society

Robust Classification of Functional and Quantitative Image Data Using Functional Mixed Models

This paper describes how to perform classification of complex, high-dimensional functional data using the functional mixed model (FMM) framework. The FMM relates a functional response to a set of predictors through functional fixed and random effects, which allows it to account for various factors and between-function correlations. Classification is performed through training the model treating class as one of the fixed effects, and then predicting on the test data using posterior predictive probabilities of class. Through a Bayesian scheme, we are able to adjust for factors affecting both the functions and the class designations. While the method we present can be applied to any FMM-based method, we provide details for two specific Bayesian approaches: the Gaussian, wavelet-based functional mixed model (G-WFMM) and the robust, wavelet-based functional mixed model (R-WFMM). Both methods perform modeling in the wavelet space, which yields parsimonious representations for the functions, and can naturally adapt to local features and complex nonstationarities in the functions. The R-WFMM allows potentially heavier tails for features of the functions indexed by particular wavelet coefficients, leading to a down weighting of outliers that makes the method robust to outlying functions or regions of functions. The models are applied to a pancreatic cancer mass spectroscopy data set and compared with some other recently developed functional classification methods

The Impact of Immunocompromise on Outcomes of COVID-19 in Children and Young People - A Systematic Review and Meta-Analysis

Background: Despite children and young people (CYP) having a low risk for severe Coronavirus disease 2019 (COVID-19) outcomes, there is still a degree of uncertainty related to their risk in the context of immunodeficiency or immunosuppression, primarily due to significant reporting bias in most studies, as CYP characteristically experience milder or asymptomatic COVID-19 infection and the severe outcomes tend to be overestimated. Methods: A comprehensive systematic review to identify globally relevant studies in immunosuppressed CYP and CYP in general population (defined as younger than 25 years of age) up to 31st October 2021 (to exclude vaccinated populations), was performed. Studies were included if they reported the two primary outcomes of our study, admission to intensive therapy unit (ITU) and mortality, while data on other outcomes, such as hospitalisation and need for mechanical ventilation were also collected. A meta-analysis estimated the pooled proportion for each severe COVID-19 outcome, using the inverse variance method. Random effects models were used to account for interstudy heterogeneity. Findings: The systematic review identified 30 eligible studies for each of the two populations investigated: immunosuppressed CYP (n=793) and CYP in general population (n=102,022). Our meta-analysis found higher estimated prevalence for hospitalization (46% vs. 16%), ITU admission (12% vs. 2%), mechanical ventilation (8% vs. 1%) and increased mortality due to severe COVID-19 infection (6.5% vs. 0.2%) in immunocompromised CYP compared to CYP in general population. This shows an overall trend for more severe outcomes of COVID-19 infection in immunocompromised CYP, similar to adult studies. Interpretation: This is the only up to date meta-analysis in immunocompromised CYP with high global relevance, which excluded reports from hospitalised cohorts alone and included 35% studies from low- and medium-income countries. Future research is required to characterise individual subgroups of immunocompromised patients, as well as impact of vaccination on severe COVID-19 outcomes. Funding: There was no funding source specifically dedicated for this study. CC is supported by a National Institute of Health Research (NIHR) Biomedical Research Centre (BRC) at University College London Hospital (UCLH). The study was performed within the Centre for Adolescent Rheumatology Versus Arthritis at University College London (UCL), UCL Hospital and Great Ormond Street Hospital (GOSH) supported by grants from Versus Arthritis (21593 and 20164), Great Ormond Street Children’s Charity, and the NIHR-BRC at both GOSH and UCLH

Experimental results for nulling the effective thermal expansion coefficient of fused silica fibres under a static stress

We have experimentally demonstrated that the effective thermal expansion coefficient of a fused silica fibre can be nulled by placing the fibre under a particular level of stress. Our technique involves heating the fibre and measuring how the fibre length changes with temperature as the stress on the fibre was systematically varied. This nulling of the effective thermal expansion coefficient should allow for the complete elimination of thermoelastic noise and is essential for allowing second generation gravitational wave detectors to reach their target sensitivity. To our knowledge this is the first time that the cancelation of the thermal expansion coefficient with stress has been experimentally observed

How dо pesticides get into honey?

Honey is nature’s sweetest gift. But did you know that honey may contain pesticides? Farmers use pesticides to kill pests that harm their crops. But pesticides also hurt honey bees and other beneficial insects. Furthermore, when bees collect nectar from flowers which received pesticide treatments, these chemicals make their way into the honey. In the past, scientists found neonicotinoids (a class of pesticides) in about half of the honey samples collected in the United Kingdom. Since 2014, the European Union banned neonicotinoids in flowering crops that bees visit. We wanted to know how effective this policy was. Does UK honey still contain neonicotinoids? Here, we collected and tested honey samples from beekeepers across the UK. We found that about a fifth of all honey contained neonicotinoids. These chemicals are not at dangerous levels for human health but may harm the bees in the long run

Tell formation processes as indicated from geoarchaeological and geochemical investigations at Xeropolis, Euboea, Greece

Xeropolis is a tell site on the island of Euboea, Greece just to the east of the village of Lefkandi, and was occupied from the Early Bronze Age to the Early Iron Age. Excavations in recent years have provided an opportunity to investigate site formation processes using geoarchaeological and geochemical techniques. Sediments derived from the tell on the southern side have been lost by coastal erosion whilst those on the north mantle the flanking slope. Of particular interest is a homogeneous and unstratified deposit of over 2 m which overlies the archaeology near the southern perimeter of the summit area. The soil structure as evident in thin sections indicates a high degree of bioturbation, probably stimulated by recent manuring and cultivation. The implication is that tillage erosion has had a major impact on the morphology as well as on the surface soils of the tell. Despite such reworking and redeposition of near surface materials, it is still possible from multi-element analysis to identify the geochemical distinctiveness of six archaeological contexts (pit, house, plaster floor, alley, road and yard); pits and floors have high loadings of all elements except Pb; in contrast pits and floors have the lowest elemental concentrations