Deep Optical Observations of Compact Groups of Galaxies

Compact groups of galaxies appear to be extremely dense, making them likely sites of intense galaxy interaction, while their small populations make them relatively simple to analyze. In order to search for optical interaction tracers such as diffuse light and galaxy tidal features in Hickson compact groups (HCGs), we carried out deep photometry in three filters on a sample of HCGs with $ROSAT$ observations. Using a modeling procedure to subtract the light of bright early-type galaxies, we found shell systems and extended envelopes around many, but not all, of those galaxies. Only one group in our sample, HCG 94, has diffuse light in the group potential (with a luminosity of 7 L$^*$); the other groups do not contain more than 1/3 L$^*$ in diffuse light. With the exception of HCG 94 (which is the most X-ray--luminous HCG), we found no correlation between the presence of shells or other tidal features and the X-ray luminosity of a group. Better predictors of detectable group X-ray emission are a low spiral fraction and belonging to a larger galaxy condensation---neither of which are correlated with optical disturbances in the group galaxies. Two elliptical galaxies that are extremely optically luminous but X-ray--faint are found to have shells and very complex color structures. This is likely due to recent infall of gas-rich material into the galaxies, which would produce both the disruption of stellar orbits and a significant amount of star formation.Comment: 24 pages, to appear in October 1995 Astronomical Journal; postscript text and figures (low resolution scans, tar'ed and compressed) available at ftp://astro.lsa.umich.edu/pub/get/pildis

A conceptual design of a large aperture microwave radiometer geostationary platform

A conceptual design of a Large Aperture Microwave Radiometer (LAMR) Platform has been developed and technology areas essential to the design and on-orbit viability of the platform have been defined. Those technologies that must be developed to the requirement stated here for the LAMR mission to be viable include: advanced radiation resistant solar cells, integrated complex structures, large segmented reflector panels, sub 3 kg/m(exp 2) areal density large antennas, and electric propulsion systems. Technology areas that require further development to enhance the capabilities of the LAMR platform (but are not essential for viability) include: electrical power storage, on-orbit assembly, and on-orbit systems checkout and correction

Systematic review of SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes

Background Despite the number of medications for type 2 diabetes, many people with the condition do not achieve good glycaemic control. Some existing glucose-lowering agents have adverse effects such as weight gain or hypoglycaemia. Type 2 diabetes tends to be a progressive disease, and most patients require treatment with combinations of glucose-lowering agents. The sodium glucose co-transporter 2 (SGLT2) receptor inhibitors are a new class of glucose-lowering agents. Objective To assess the clinical effectiveness and safety of the SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes. Data sources MEDLINE, Embase, Cochrane Library (all sections); Science Citation Index; trial registries; conference abstracts; drug regulatory authorities; bibliographies of retrieved papers. Inclusion criteria Randomised controlled trials of SGLT2 receptor inhibitors compared with placebo or active comparator in type 2 diabetes in dual or combination therapy. Methods Systematic review. Quality assessment used the Cochrane risk of bias score. Results Seven trials, published in full, assessed dapagliflozin and one assessed canagliflozin. Trial quality appeared good. Dapagliflozin 10 mg reduced HbA1c by −0.54% (weighted mean differences (WMD), 95% CI −0.67 to −0.40) compared to placebo, but there was no difference compared to glipizide. Canagliflozin reduced HbA1c slightly more than sitagliptin (up to −0.21% vs sitagliptin). Both dapagliflozin and canagliflozin led to weight loss (dapagliflozin WMD −1.81 kg (95% CI −2.04 to −1.57), canagliflozin up to −2.3 kg compared to placebo). Limitations Long-term trial extensions suggested that effects were maintained over time. Data on canagliflozin are currently available from only one paper. Costs of the drugs are not known so cost-effectiveness cannot be assessed. More data on safety are needed, with the Food and Drug Administration having concerns about breast and bladder cancers. Conclusions Dapagliflozin appears effective in reducing HbA1c and weight in type 2 diabetes, although more safety data are needed

Relationships between cord blood leptin and ghrelin levels, milk intake and weight gain in human infants

Leptin and ghrelin are hormones involved in the regulation of appetite and adiposity. Leptin suppresses appetite and induces weight loss; ghrelin stimulates appetite and promotes weight gain. The study reported in this thesis was designed to examine the relationship of cord blood leptin and ghrelin with milk intake over the first week of life, and with infant growth up to twelve weeks of age. One hundred term formula fed newborns were recruited at birth. Leptin and ghrelin were measured in cord blood by radioimmunoassay. Milk intake was measured by weighing of bottles of formula milk before and after feeding. Measurements of weight, length and head circumference were taken at birth, seven days and at twelve weeks of age. A number of control variables were also measured. Birthweight was a significant predictor of mean milk intake, which rose significantly from days 1 to 7, with no difference between males and females. Weight gain or loss in the early neonatal period was a direct and significant consequence of milk intake consumed over that period. There was no relationship between cord blood leptin or ghrelin (controlling for birthweight) on the infants' milk intake over the first 24 hours of life or on their mean milk intake over the first week of life. Weight gain was significantly correlated with birthweight, with higher birthweight associated with lower weight gain. There was no relationship between cord leptin and weight gain to three months of age after adjusting for birthweight; but lower cord ghrelin levels were significantly associated with slower weight gain

Comparative Microbial Dynamics in Crassostrea virginica and Crassostrea ariakensis

Considerations to introduce the Suminoe or Asian oyster Crassostrea ariakensis along the East Coast have raised many questions regarding ecology, economics, and human health. To date, research has focused primarily on the ecological and socioeconomic implications of this initiative, yet few studies have assessed its potential impact on public health. Our work compares the rates of bioaccumulation, depuration and post harvest decay of indicator organisms (such as E. coli) and Vibrio sp. between Crassostrea virginica and Crassostrea ariakensis in the laboratory. Preliminary results suggest that the rates of bioaccumulation of E. coli in Crassostrea ariakensis were significantly lower than those for Crassostrea virginica, depuration of E. coli was variable between the two species, and Crassostrea ariakensis post harvest decay rates of Vibrio sp. were significantly lower than Crassostrea virginica. This research provides coastal managers with insight into the response of Crassostrea ariakensis to bacteria, an important consideration for determining appropriate management strategies for this species. Further field-based studies will be necessary to elucidate the mechanisms responsible for the differences in rates of bioaccumulation and depuration. (PDF contains 40 pages

Elevated pCO2 enhances bacterioplankton removal of organic carbon.

Factors that affect the removal of organic carbon by heterotrophic bacterioplankton can impact the rate and magnitude of organic carbon loss in the ocean through the conversion of a portion of consumed organic carbon to CO2. Through enhanced rates of consumption, surface bacterioplankton communities can also reduce the amount of dissolved organic carbon (DOC) available for export from the surface ocean. The present study investigated the direct effects of elevated pCO2 on bacterioplankton removal of several forms of DOC ranging from glucose to complex phytoplankton exudate and lysate, and naturally occurring DOC. Elevated pCO2 (1000-1500 ppm) enhanced both the rate and magnitude of organic carbon removal by bacterioplankton communities compared to low (pre-industrial and ambient) pCO2 (250 -~400 ppm). The increased removal was largely due to enhanced respiration, rather than enhanced production of bacterioplankton biomass. The results suggest that elevated pCO2 can increase DOC consumption and decrease bacterioplankton growth efficiency, ultimately decreasing the amount of DOC available for vertical export and increasing the production of CO2 in the surface ocean

Balancing conservation with national development: a socio-economic case study of the alternatives to the Serengeti Road

Developing countries often have rich natural resources but poor infrastructure to capitalize on them, which leads to significant challenges in terms of balancing poverty alleviation with conservation. The underlying premise in development strategies is to increase the socio-economic welfare of the people while simultaneously ensuring environmental sustainability, however these objectives are often in direct conflict. National progress is dependent on developing infrastructure such as effective transportation networks, however roads can be ecologically catastrophic in terms of disrupting habitat connectivity and facilitating illegal activity. How can national development and conservation be balanced? The proposed Serengeti road epitomizes the conflict between poverty alleviation on one hand, and the conservation of a critical ecosystem on the other. We use the Serengeti as an exemplar case-study in which the relative economic and social benefits of a road can be assessed against the ecological impacts. Specifically, we compare three possible transportation routes and ask which route maximizes the socio-economic returns for the people while minimizing the ecological costs. The findings suggest that one route in particular that circumnavigates the Serengeti links the greatest number of small and medium sized entrepreneurial businesses to the largest labour force in the region. Furthermore, this route connects the most children to schools, provisions the greatest access to hospitals, and opens the most fertile crop and livestock production areas, and does not compromise the ecology and tourism revenue of the Serengeti. This route would improve Tanzania’s food security and self-reliance and would facilitate future infrastructure development which would not be possible if the road were to pass through the Serengeti. This case study provides a compelling example of how a detailed spatial analysis can balance the national objectives of poverty alleviation while maintaining ecological integrity