CRiBAC: Community-centric role interaction based access control model

As one of the most efficient solutions to complex and large-scale problems, multi-agent cooperation has been in the limelight for the past few decades. Recently, many research projects have focused on context-aware cooperation to dynamically provide complex services. As cooperation in the multi-agent systems (MASs) becomes more common, guaranteeing the security of such cooperation takes on even greater importance. However, existing security models do not reflect the agents' unique features, including cooperation and context-awareness. In this paper, we propose a Community-based Role interaction-based Access Control model (CRiBAC) to allow secure cooperation in MASs. To do this, we refine and extend our preliminary RiBAC model, which was proposed earlier to support secure interactions among agents, by introducing a new concept of interaction permission, and then extend it to CRiBAC to support community-based cooperation among agents. We analyze potential problems related to interaction permissions and propose two approaches to address them. We also propose an administration model to facilitate administration of CRiBAC policies. Finally, we present the implementation of a prototype system based on a sample scenario to assess the proposed work and show its feasibility. © 2012 Elsevier Ltd. All rights reserved

Severity of curvularia stem blight disease of cassava in West Africa

In diagnostic surveys, Curvularia stem blight affected 9, 13, and 38% of cassava fields, respectively, in Benin, Ghana, and Nigeria. Disease incidence (number of plants with visible symptoms per total sampled) ranged between 0 and 80%, and severity (number of lesions) between 2 and 25 lesions per stem. In greenhouse studies, the fungus inhibited shoot growth depending on the degree of bud colonization, such that when buds were completely colonized, they failed to sprout. Partially colonized buds sprouted, but depending on genotype, overall growth was reduced 20 to 50% compared with healthy stems. Shoot growth for all artificially inoculated cultivars was consistently lower than for the respective noninoculated plants, and they suffered up to 50% leaf abscission. In two field localities, shoot sprouting for cultivars TMS 30572 and Odongbo was reduced 4 to 18% and 26 to 58% compared with noninoculated stems

Dissociative covalent adaptable networks from unsaturated polyesters

Unsaturated polyesters (UPEs) are a class of thermosetting resins which are prevalent in the polymer industry, offering excellent durability in many applications. However, their permanent crosslinks prevent re-use or recycling at their end-of-life. This problem is addressed using UPEs to generate dissociative covalent adaptable networks (CANs). Poly(propylene maleate) and poly(propylene fumarate) were copolymerised with furan-functionalised crosslinkers to form networks comprising reversible Diels-Alder cycloadducts. The thermal properties of each material were analysed by differential scanning calorimetry (DSC), showing that the furan-maleate networks dissociated at 130 °C compared to the furan-fumarate networks which dissociated at a significantly lower temperature (100 °C). The network formed from poly(propylene maleate) using a flexible trifunctional furan crosslinker provided the largest increase in T g and T rDA, producing the highest gel fraction (99 %) and a stable plateau modulus of 10 MPa by DMA. The networks reform at ambient temperature, although the rate of formation can be increased significantly by mild heating at 65 °C. Overall, the results indicate that furan-maleate CANs behave like reference furan-maleimide networks. Thermal analysis indicated that the furan-maleate cycloadduct was retained by heating to 150 °C, whereas isomerisation of maleate to fumarate was observed after repeated heating cycles to 180 °C. Mechanical testing showed that a bond strength of almost 10 MPa was achieved using these CANs as adhesives, which could be readily modified through changes in copolymer composition

Nucleon Charge and Magnetization Densities from Sachs Form Factors

Relativistic prescriptions relating Sachs form factors to nucleon charge and magnetization densities are used to fit recent data for both the proton and the neutron. The analysis uses expansions in complete radial bases to minimize model dependence and to estimate the uncertainties in radial densities due to limitation of the range of momentum transfer. We find that the charge distribution for the proton is significantly broad than its magnetization density and that the magnetization density is slightly broader for the neutron than the proton. The neutron charge form factor is consistent with the Galster parametrization over the available range of Q^2, but relativistic inversion produces a softer radial density. Discrete ambiguities in the inversion method are analyzed in detail. The method of Mitra and Kumari ensures compatibility with pQCD and is most useful for extrapolating form factors to large Q^2.Comment: To appear in Phys. Rev. C. Two new figures and accompanying text have been added and several discussions have been clarified with no significant changes to the conclusions. Now contains 47 pages including 21 figures and 2 table

Dynamical Renormalization Group Approach to Quantum Kinetics in Scalar and Gauge Theories

We derive quantum kinetic equations from a quantum field theory implementing a diagrammatic perturbative expansion improved by a resummation via the dynamical renormalization group. The method begins by obtaining the equation of motion of the distribution function in perturbation theory. The solution of this equation of motion reveals secular terms that grow in time, the dynamical renormalization group resums these secular terms in real time and leads directly to the quantum kinetic equation. We used this method to study the relaxation in a cool gas of pions and sigma mesons in the O(4) chiral linear sigma model. We obtain in relaxation time approximation the pion and sigma meson relaxation rates. We also find that in large momentum limit emission and absorption of massless pions result in threshold infrared divergence in sigma meson relaxation rate and lead to a crossover behavior in relaxation. We then study the relaxation of charged quasiparticles in scalar electrodynamics (SQED). While longitudinal, Debye screened photons lead to purely exponential relaxation, transverse photons, only dynamically screened by Landau damping lead to anomalous relaxation, thus leading to a crossover between two different relaxational regimes. We emphasize that infrared divergent damping rates are indicative of non-exponential relaxation and the dynamical renormalization group reveals the correct relaxation directly in real time. Finally we also show that this method provides a natural framework to interpret and resolve the issue of pinch singularities out of equilibrium and establish a direct correspondence between pinch singularities and secular terms. We argue that this method is particularly well suited to study quantum kinetics and transport in gauge theories.Comment: RevTeX, 40 pages, 4 eps figures, published versio

No additional prognostic value of genetic information in the prediction of vascular events after cerebral ischemia of arterial origin

Background: Patients who have suffered from cerebral ischemia have a high risk of recurrent vascular events. Predictive models based on classical risk factors typically have limited prognostic value. Given that cerebral ischemia has a heritable component, genetic information might improve performance of these risk models. Our aim was to develop and compare two models: one containing traditional vascular risk factors, the other also including genetic information. Methods and Results: We studied 1020 patients with cerebral ischemia and genotyped them with the Illumina Immunochip. Median follow-up time was 6.5 years; the annual incidence of new ischemic events (primary outcome, n=198) was 3.0%. The prognostic model based on classical vascular risk factors had an area under the receiver operating characteristics curve (AUC-ROC) of 0.65 (95% confidence interval 0.61-0.69). When we added a genetic risk score based on prioritized SNPs from a genome-wide association study of ischemic stroke (using summary statistics from the METASTROKE study which included 12389 cases and 62004 controls), the AUC-ROC remained the same. Similar results were found for the secondary outcome ischemic stroke. Conclusions: We found no additional value of genetic information in a prognostic model for the risk of ischemic events in patients with cerebral ischemia of arterial origin. This is consistent with a complex, polygenic architecture, where many genes of weak effect likely act in concert to influence the heritable risk of an individual to develop (recurrent) vascular events. At present, genetic information cannot help clinicians to distinguish patients at high risk for recurrent vascular events

Genetic overlap between diagnostic subtypes of ischemic stroke

Background and Purpose: Despite moderate heritability, the phenotypic heterogeneity of ischemic stroke has hampered gene discovery, motivating analyses of diagnostic subtypes with reduced sample sizes. We assessed evidence for a shared genetic basis among the 3 major subtypes: large artery atherosclerosis (LAA), cardioembolism, and small vessel disease (SVD), to inform potential cross-subtype analyses. Methods: Analyses used genome-wide summary data for 12 389 ischemic stroke cases (including 2167 LAA, 2405 cardioembolism, and 1854 SVD) and 62 004 controls from the Metastroke consortium. For 4561 cases and 7094 controls, individual-level genotype data were also available. Genetic correlations between subtypes were estimated using linear mixed models and polygenic profile scores. Meta-analysis of a combined LAA-SVD phenotype (4021 cases and 51 976 controls) was performed to identify shared risk alleles. Results: High genetic correlation was identified between LAA and SVD using linear mixed models (rg=0.96, SE=0.47, P=9×10-4) and profile scores (rg=0.72; 95% confid

Selenium and vitamin E for prevention of non–muscle-invasive bladder cancer recurrence and progression

Importance Selenium and vitamin E have been identified as promising agents for the chemoprevention of recurrence and progression of non–muscle-invasive bladder cancer. Objective To determine whether selenium and/or vitamin E may prevent disease recurrence in patients with newly diagnosed NMIBC. Design, Setting, and Participants This multicenter, prospective, double-blinded, placebo-controlled, 2 × 2 factorial randomized clinical trial included patients with newly diagnosed NMIBC recruited from 10 secondary or tertiary care hospitals in the UK. A total of 755 patients were screened for inclusion; 484 did not meet the inclusion criteria, and 1 declined to participate. A total of 270 patients were randomly assigned to 4 groups (selenium plus placebo, vitamin E plus placebo, selenium plus vitamin E, and placebo plus placebo) in a double-blind fashion between July 17, 2007, and October 10, 2011. Eligibility included initial diagnosis of NMIBC (stages Ta, T1, or Tis); randomization within 12 months of first transurethral resection was required. Interventions Oral selenium (200 μg/d of high-selenium yeast) and matched vitamin E placebo, vitamin E (200 IU/d of d-alfa-tocopherol) and matched selenium placebo, selenium and vitamin E, or placebo and placebo. Main Outcome and Measures Recurrence-free interval (RFI) on an intention-to-treat basis (analyses completed on November 28, 2022). Results The study randomized 270 patients (mean [SD] age, 68.9 [10.4] years; median [IQR] age, 69 [63-77] years; 202 male [75%]), with 65 receiving selenium and vitamin E placebo, 71 receiving vitamin E and selenium placebo, 69 receiving selenium and vitamin E, and 65 receiving both placebos. Median overall follow-up was 5.5 years (IQR, 5.1-6.1 years); 228 patients (84%) were followed up for more than 5 years. Median treatment duration was 1.5 years (IQR, 0.9-2.5 years). The study was halted because of slow accrual. For selenium (n = 134) vs no selenium (n = 136), there was no difference in RFI (hazard ratio, 0.92; 95% CI, 0.65-1.31; P = .65). For vitamin E (n = 140) vs no vitamin E (n = 130), there was a statistically significant detriment to RFI (hazard ratio, 1.46; 95% CI, 1.02-2.09; P = .04). No significant differences were observed for progression-free interval or overall survival time with either supplement. Results were unchanged after Cox proportional hazards regression modeling to adjust for known prognostic factors. In total, 1957 adverse events were reported; 85 were serious adverse events, and all were considered unrelated to trial treatment. Conclusions and Relevance In this randomized clinical trial of selenium and vitamin E, selenium supplementation did not reduce the risk of recurrence in patients with NMIBC, but vitamin E supplementation was associated with an increased risk of recurrence. Neither selenium nor vitamin E influenced progression or overall survival. Vitamin E supplementation may be harmful to patients with NMIBC, and elucidation of the underlying biology is required