34 research outputs found
Dietary determinants of changes in waist circumference adjusted for body mass index - a proxy measure of visceral adiposity
Background Given the recognized health effects of visceral fat, the understanding of how diet can modulate changes in the phenotype âwaist circumference for a given body mass index (WCBMI)â, a proxy measure of visceral adiposity, is deemed necessary. Hence, the objective of the present study was to assess the association between dietary factors and prospective changes in visceral adiposity as measured by changes in the phenotype WCBMI. Methods and Findings We analyzed data from 48,631 men and women from 5 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Anthropometric measurements were obtained at baseline and after a median follow-up time of 5.5 years. WCBMI was defined as the residuals of waist circumference regressed on body mass index, and annual change in WCBMI (ÂżWCBMI, cm/y) was defined as the difference between residuals at follow-up and baseline, divided by follow-up time. The association between energy, energy density (ED), macronutrients, alcohol, glycemic index (GI), glycemic load (GL), fibre and ÂżWCBMI was modelled using centre-specific adjusted linear regression, and random-effects meta-analyses to obtain pooled estimates. Men and women with higher ED and GI diets showed significant increases in their WCBMI, compared to those with lower ED and GI [1 kcal/g greater ED predicted a ÂżWCBMI of 0.09 cm (95% CI 0.05 to 0.13) in men and 0.15 cm (95% CI 0.09 to 0.21) in women; 10 units greater GI predicted a ÂżWCBMI of 0.07 cm (95% CI 0.03 to 0.12) in men and 0.06 cm (95% CI 0.03 to 0.10) in women]. Among women, lower fibre intake, higher GL, and higher alcohol consumption also predicted a higher ÂżWCBMI. Conclusions Results of this study suggest that a diet with low GI and ED may prevent visceral adiposity, defined as the prospective changes in WCBMI. Additional effects may be obtained among women of low alcohol, low GL, and high fibre intake
Large-Scale Structure at z~2.5
We have made a statistically complete, unbiased survey of C IV systems toward
a region of high QSO density near the South Galactic Pole using 25 lines of
sight spanning . Such a survey makes an excellent probe of
large-scale structure at early epochs. We find evidence for structure on the
proper Mpc scale ( km Mpc) as
determined by the two point C IV - C IV absorber correlation function, and
reject the null hypothesis that C IV systems are distributed randomly on such
scales at the level. The structure likely reflects the
distance between two groups of absorbers subtending and Mpc at and respectively. There is also a marginal trend for the association of
high rest equivalent width C IV absorbers and QSOs at similar redshifts but
along different lines of sight. The total number of C IV systems detected is
consistent with that which would be expected based on a survey using many
widely separated lines of sight. Using the same data, we also find 11 Mg II
absorbers in a complete survey toward 24 lines of sight; there is no evidence
for Mg II - Mg II or Mg II - QSO clustering, though the sample size is likely
still small to detect such structure if it exists.Comment: 56 pages including 32 of figures, in gzip-ed uuencoded postscript
format, 1 long table not included, aastex4 package. Accepted for publication
in ApJ Supplement
Unitary Positive-Energy Representations of Scalar Bilocal Quantum Fields
The superselection sectors of two classes of scalar bilocal quantum fields in
D>=4 dimensions are explicitly determined by working out the constraints
imposed by unitarity. The resulting classification in terms of the dual of the
respective gauge groups U(N) and O(N) confirms the expectations based on
general results obtained in the framework of local nets in algebraic quantum
field theory, but the approach using standard Lie algebra methods rather than
abstract duality theory is complementary. The result indicates that one does
not lose interesting models if one postulates the absence of scalar fields of
dimension D-2 in models with global conformal invariance. Another remarkable
outcome is the observation that, with an appropriate choice of the Hamiltonian,
a Lie algebra embedded into the associative algebra of observables completely
fixes the representation theory.Comment: 27 pages, v3: result improved by eliminating redundant assumptio
Efficacy of dose-escalated chemoradiation on complete tumour response in patients with locally advanced rectal cancer (RECTAL-BOOST); a phase 2 randomised controlled trial
Purpose
Pathological complete tumour response following chemoradiation in patients with locally advanced rectal cancer (LARC) is associated with favourable prognosis and allows organ-sparing treatment strategies. We aimed to investigate the effect of an external radiation boost to the tumour prior to chemoradiation on pathological or sustained clinical complete tumour response in LARC.
Methods and materials
This multicentre, non-blinded, phase 2, randomised controlled trial followed the trials within cohorts-design, which is a pragmatic trial design allowing cohort participants to be randomized for an experimental intervention. Patients in the intervention group are offered the intervention (and can accept or refuse this), whereas patients in the control group are not notified about the randomisation. Participants of a colorectal cancer cohort referred for chemoradiation of LARC to either of two radiotherapy centres were eligible. Patients were randomised to no boost or an external radiation boost (5 x 3 Gy) without concurrent chemotherapy directly followed by standard pelvic chemoradiation (25 x 2 Gy with concurrent capecitabine). The primary outcome was pathological complete response (pCR, i.e. ypT0N0) in patients with planned surgery at 12 weeks or, as surrogate for pCR, a 2-year sustained clinical complete response for patients treated with an organ preservation strategy. Analyses were intention to treat. The study was registered with ClinicalTrials.gov, number NCTXXXXXX.
Results
Between Sept 2014 and July 2018, 128 patients were randomised. Fifty-one of the 64 (79.7%) patients in the intervention group accepted and received a boost. Compared with the control group, fewer patients in the intervention group had a cT4-stage and a low rectal tumour (31.3% versus 17.2% and 56.3% versus 45.3% respectively), and more patients had a cN2-stage (59.4% versus 70.3% respectively). Rate of pathological or sustained clinical complete tumour response was similar between the groups: 23 of 64 (35.9%, 95%CI 24.3-48.9) in the intervention group versus 24 of 64 (37.5%, 95%CI 25.7-50.5) in the control group (OR=0.94 95%CI 0.46-1.92). Near-complete or complete tumour regression was more common in the intervention group: 34 of 49 (69.4%) versus 24 of 53 (45.3%) in the control group (OR=2.74, 95%CI 1.21-6.18). Grade >3 acute toxicity was comparable: 6 of 64 (9.4%) in the intervention group versus 5 of 64 (7.8%) in the control group (OR=1.22 95%CI 0.35-4.22).
Conclusion
Dose escalation with an external radiotherapy boost to the tumour prior to neoadjuvant chemoradiation did not increase the pathological or sustained clinical complete tumour response rate in LARC