Cemented hemi arthroplasty for unstable intertrochanteric fractures in elderly

Background: The incidence of the intertrochanteric fractures is increasing in recent times. It is found that more and more of these fractures are seen in elderly. The treatment of these fractures was historically non surgical. The use of dynamic hip screw and angled blade plate in the surgical management of these fractures is a recent practice. The objective of the study was to analyse the role of cemented hemi-arthroplasty in the treatment of unstable inter trochanteric fractures in elderly.Methods: This study was conducted between June 2014 to June 2016. Results were analysed prospectively. From a total 94 inter trochanteric fractures admitted during this period 20 patients were chosen who fulfilled our inclusion criteria. All the patients were treated in Malla Reddy Institute of Medical Sciences. Primary cemented hemiarthroplasty was done in the entire patient by a senior faculty member. The results were assessed according to Harris hip score.Results: There were 13 females and 7 males in our study. The average age was 69.2 years. There was Evan’s type 1-c 11, 1-d 7 and 1-e 2 in numbers all the patients were followed up for a period of 18 months.Conclusions: In our short study, it is concluded that the primary cemented hemi arthroplasty is a good option in unstable inter trochanteric fractures in elderly

Amplification of Fluctuations in Unstable Systems with Disorder

We study the early-stage kinetics of thermodynamically unstable systems with quenched disorder. We show analytically that the growth of initial fluctuations is amplified by the presence of disorder. This is confirmed by numerical simulations of morphological phase separation (MPS) in thin liquid films and spinodal decomposition (SD) in binary mixtures. We also discuss the experimental implications of our results.Comment: 15 pages, 4 figure

Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors.

Inhibition of PIKfyve phosphoinositide kinase selectively kills autophagy-dependent cancer cells by disrupting lysosome homeostasis. Here, we show that PIKfyve inhibitors can also selectively eliminate pluripotent embryonal carcinoma cells (ECCs), embryonic stem cells, and induced pluripotent stem cells under conditions where differentiated cells remain viable. PIKfyve inhibitors prevented lysosome fission, induced autophagosome accumulation, and reduced cell proliferation in both pluripotent and differentiated cells, but they induced death only in pluripotent cells. The ability of PIKfyve inhibitors to distinguish between pluripotent and differentiated cells was confirmed with xenografts derived from ECCs. Pretreatment of ECCs with the PIKfyve specific inhibitor WX8 suppressed their ability to form teratocarcinomas in mice, and intraperitoneal injections of WX8 into mice harboring teratocarcinoma xenografts selectively eliminated pluripotent cells. Differentiated cells continued to proliferate, but at a reduced rate. These results provide a proof of principle that PIKfyve specific inhibitors can selectively eliminate pluripotent stem cells in vivo as well as in vitro

Mitigation of nitrous oxide emissions in grazing systems through nitrifcation inhibitors: a meta‑analysis

Grasslands are the largest contributor of nitrous oxide (N2O) emissions in the agriculture sector due to livestock excreta and nitrogen fertilizers applied to the soil. Nitrification inhibitors (NIs) added to N input have reduced N2O emissions, but can show a range of efficiencies depending on climate, soil, and management conditions. A meta-analysis study was conducted to investigate the factors that influence the efficiency of NIs added to fertilizer and excreta in reducing N2O emissions, focused on grazing systems. Data from peer-reviewed studies comprising 2164 N2O emission factors (EFs) of N inputs with and without NIs addition were compared. The N2O EFs varied according to N source (0.0001–8.25%). Overall, NIs reduced the N2O EF from N addition by 56.6% (51.1–61.5%), with no difference between NI types (Dicyandiamide—DCD; 3,4-Dimethylpyrazole phosphate—DMPP; and Nitrapyrin) or N source (urine, dung, slurry, and fertilizer). The NIs were more efficient in situations of high N2O emissions compared with low; the reduction was 66.0% when EF>1.5% of N applied compared with 51.9% when EF≤0.5%. DCD was more efficient when applied at rates>10 kg ha−1. NIs were less efficient in urine with lower N content (≤7 g kg−1). NI efficiency was negatively correlated with soil bulk density, and positively correlated with soil moisture and temperature. Better understanding and management of NIs can optimize N2O mitigation in grazing systems, e.g., by mapping N2O risk and applying NI at variable rate, contributing to improved livestock sustainabilit

Wavelength-resolved Reverberation Mapping of quasar CTSC30.10: Dissecting MgII and FeII emission regions

We present the results of the reverberation monitoring aimed at MgII broad line and FeII pseudocontinuum for the luminous quasar CTS C30.10 (z = 0.90052) with the Southern African Large Telescope covering the years 2012-2021. We aimed at disentangling the MgII and UV FeII variability and the first measurement of UV FeII time delay for a distant quasar. We used several methods for time-delay measurements and determined both FeII and MgII time delays as well as performed a wavelength-resolved time delay study for a combination of MgII and FeII in the 2700 - 2900 \AA restframe wavelength range. We obtain the time delay for MgII of $275.5^{+12.4}_{-19.5}$ days in the rest frame, while for FeII we have two possible solutions of $270.0^{+13.8}_{-25.3}$ days and $180.3^{+26.6}_{-30.0}$ in the rest frame. Combining this result with the old measurement of FeII UV time delay for NGC 5548 we discuss for the first time the radius-luminosity relation for UV FeII with the slope consistent with $0.5$ within uncertainties. Since FeII time delay has a shorter time-delay component but lines are narrower than MgII, we propose that the line delay measurement is biased towards the BLR part facing the observer, with the bulk of the Fe II emission may arise from the more distant BLR region, one that is shielded from the observer.Comment: 22 pages, 19 Figures, 6 Tables, Submitted to Astronomy and Astrophysics, Comments are welcom

Wavelength-resolved reverberation mapping of intermediate redshift quasars HE 0413-4031 and HE 0435-4312: Dissecting Mg II, optical Fe II, and UV Fe II emission regions

We present the wavelength-resolved reverberation mapping (RM) of combined MgII and UV FeII broad-line emissions for two intermediate redshifts (z$\sim$1), luminous quasars - HE 0413-4031 and HE 0435-4312, monitored by the SALT and 1-m class telescopes between 2012-2022. Through this technique, we aim to disentangle the Mg II and FeII emission regions and to build a radius-luminosity relation for UV FeII emission, which has so far remained unconstrained. Several methodologies have been applied to constrain the time delays for total MgII and FeII emissions. In addition, this technique is performed to quantify the inflow or outflow of broad-line region gas around the supermassive black hole and to disentangle the emission/emitting regions from lines produced in proximity to each other. The mean total FeII time delay is nearly equal to the mean total Mg II time delay for HE 0435-4312 suggesting a co-spatiality of their emissions. However, in HE 0413-4031, the mean FeII time delay is found to be longer than the mean MgII time delay, suggesting that FeII is produced at longer distances from the black hole. The UV Fe II R-L relation is updated with these two quasars and compared with the optical FeII relation, which suggests that the optical FeII region is located further than the UV FeII by a factor of 1.7-1.9 i.e. $R_{\rm FeII-opt}\sim(1.7-1.9)R_{\rm FeII-UV}$. We detected a weak pattern in the time delay vs. wavelength relation, suggesting that the MgII broad-line originates a bit closer to the SMBH than the UV FeII, however, the difference is not very significant. Comparison of MgII, UV, and optical FeII R-L relations suggests that the difference may be larger for lower-luminosity sources, possibly with the MgII emission originating further from the SMBH. In the future, more RM data will be acquired to put better constraints on these trends, in particular the UV FeII R-L relation.Comment: 24 pages, 16 figures, 5 tables, Accepted for publication in A&A, in Pres

Ideas for Improving the Field of Machine Learning: Summarizing Discussion from the NeurIPS 2019 Retrospectives Workshop

This report documents ideas for improving the field of machine learning, which arose from discussions at the ML Retrospectives workshop at NeurIPS 2019. The goal of the report is to disseminate these ideas more broadly, and in turn encourage continuing discussion about how the field could improve along these axes. We focus on topics that were most discussed at the workshop: incentives for encouraging alternate forms of scholarship, re-structuring the review process, participation from academia and industry, and how we might better train computer scientists as scientists. Videos from the workshop can be accessed at https://slideslive.com/neurips/west-114-115-retrospectives-a-venue-for-selfreflection-in-ml-researc

Gramene 2013: comparative plant genomics resources

Gramene (http://www.gramene.org) is a curated online resource for comparative functional genomics in crops and model plant species, currently hosting 27 fully and 10 partially sequenced reference genomes in its build number 38. Its strength derives from the application of a phylogenetic framework for genome comparison and the use of ontologies to integrate structural and functional annotation data. Whole-genome alignments complemented by phylogenetic gene family trees help infer syntenic and orthologous relationships. Genetic variation data, sequences and genome mappings available for 10 species, including Arabidopsis, rice and maize, help infer putative variant effects on genes and transcripts. The pathways section also hosts 10 species-specific metabolic pathways databases developed in-house or by our collaborators using Pathway Tools software, which facilitates searches for pathway, reaction and metabolite annotations, and allows analyses of user-defined expression datasets. Recently, we released a Plant Reactome portal featuring 133 curated rice pathways. This portal will be expanded for Arabidopsis, maize and other plant species. We continue to provide genetic and QTL maps and marker datasets developed by crop researchers. The project provides a unique community platform to support scientific research in plant genomics including studies in evolution, genetics, plant breeding, molecular biology, biochemistry and systems biology

Evolution in the split-peak structure across the Peak Effect region in single crystals of 2H2H-NbSe2_2

We have explored the presence of a two-peak feature spanning the peak effect (PE) region in the ac susceptibility data and the magnetization hysteresis measurements over a wide field-temperature regime in few weakly pinned single crystals of $2H$-NbSe$_2$, which display reentrant characteristic in the PE curve near $T_c$(0). We believe that the two-peak feature evolves into distinct second magnetization peak anomaly well separated from the PE with gradual enhancement in the quenched random pinning.Comment: 9 figure