Making Connaught Place (New Delhi, India) Bicycle And Pedestrian Friendly

India is a place where people have walked miles since ancient times for basic day-to-day needs like water, food, education, shopping, entertainment, tourism, and shelter. However, the rapid growth in population and urbanization is changing the way people live and commute. The urban sprawl is pushing people to the outskirts of the city core because of which personal automobiles is becoming the main source of transportation. This is leading to congestion on roads for most times of the day. The objective of this thesis is to explore and examine how to improve pedestrian and bicycle facilities in a prominent commercial and retail center in New Delhi, India and to identify design strategies to alleviate the problems of air pollution and traffic congestion. Due to rapid urbanization and globalization, the number of motorized vehicles between 2008 and 2018 has increased by 17% in New Delhi (According to Delhi Traffic Police). The population rise within the same time has been 55% as per the census of India. Government organizations have identified polluting emissions from vehicles as a dominant source of high air pollution levels in Delhi. There is an urgent need to plan for non-motorized transport (NMT) as pedestrian facilities and green infrastructure can help to enhance the environment of the capital city. The concern is less about the willingness of people to use NMT and more about the absence of proper facilities. Connaught Place in New Delhi is a good example because increase in automobile traffic has adversely impacted the physical environment around the area. It is a major business and economic hub of great historical importance for the city. This thesis aims to propose a planned layout to accommodate the users and make the busy circle pedestrian and bicycle friendly

New Directions in Workforce Development: Do They Lead to Gains For Women?

In order to achieve gender equality, it is critical to resurrect women’s interests as a driving force in the formulation of workforce development policies and programs. Current workforce strategies are centered on helping economically disadvantaged individuals gain employment in high demand industries that offer opportunities to earn family-sustaining wages. Yet many of these high-growth industries consist of male-dominated occupations, which provide lower earnings and advancement potential for women. Because women continue to be channeled into lower-paying fields, demand-driven workforce policies may result in lower earnings for women. To address gender biases, increased emphasis should be placed on selecting jobs that lead to economic self-sufficiency, helping women access male dominated jobs, building career ladders for traditionally female-dominated fields, investing in math and science preparation for women, and closing the gender wage gap

Synthesis, characterization, drug likeliness and biological activity of imidazopyridine derivatives as anti-tubercular agents

305-312Tuberculosis is a global threat that is in urgent need for new molecules. In the same perspective, Imidazopyridine derivatives have been synthesized against target ATP synthase. It is an important enzyme that provides energy for the cell to use through the synthesis of adenosine triphosphate (ATP). ATP is the most commonly used "energy currency" of cells from most organisms. Bedaquiline that primarily targets ATP now is most effective in treatment of tuberculosis. All synthesized molecules pass Lipinski rule of 5 and are non-substrate of CYP450 enzymes. They didn’t portray significant anti-tubercular activity

A Quick Review on Data Mining Techniques

In this paper, we studied about the concept of data mining and their techniques. Data mining is a process to extract the pattern in the data from the huge amount of data. For data mining there are some techniques those are apply on the huge amount of data and extract the useful information. In this paper we can study about the categories of these techniques of data mining also to improve their businesses and found excellent results

To Study the Level of Stress among Management Trainees

Abstract Stress is experienced in organizational roles as problems are encountered in performance of the role. The Nature of Stress can be investigated by number of Attributes. There is always a difference in a way of living, of man and woman. Naturally, this also concludes the level of stress they encounter must be different. There Sample was taken from lower and middle age group belonging to various industries having differentiated work experience of zero to One year. Study focused only the management trainees. This study focuses to ensure if stress is actually affected on the basis of Gender. It also helps better appreciation of differences in problems faced by Man and Woman differently. The results of the study can help in formulating a contingency model to enhance organizational performance and effectiveness

Pattern self-medication use of analgesics in Pune, Maharashtra, India

Background: Objective of current study was to find out self-medication pattern and to study awareness of ADRs to analgesics self-medication.Methods: II MBBS students collected the information of names of analgesics self-medication, dose, frequency of administration, health related problem for use of self-medication, source of information for the use of self-medication and information about ADRs. Students also educated the population about ADRs to analgesics with the help of ADR checklist.Results: Paracetamol was most commonly taken as self-medication and 39% persons reported ADRs with paracetamol.  Ibuprofen, diclofenac, paracetamol and aspirin were taken less than WHO DDD for joint pain. 79% study population was ignorant about ADRs to analgesics. Headache (37%) was common health related problem for self-medication of analgesics.   Conclusion: Information about problems with repeated use of analgesics like liver damage, analgesic nephropathy, gastric ulceration/bleeding should be provided by pharmacists either orally or with the help of leaflets or display board. Headache is common health related problem for the use of analgesics as self-medication. Pharmacists should take help of assistance tool to diagnosis headache like screener for migraine and guidelines for chronic headache for timely visit of self-medicating person to physician.

Vaccines and allergic reactions:The past, the current COVID-19 pandemic, and future perspectives

Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur after vaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.</p

Vaccines and allergic reactions:The past, the current COVID-19 pandemic, and future perspectives

Vaccines are essential public health tools with a favorable safety profile and prophylactic effectiveness that have historically played significant roles in reducing infectious disease burden in populations, when the majority of individuals are vaccinated. The COVID-19 vaccines are expected to have similar positive impacts on health across the globe. While serious allergic reactions to vaccines are rare, their underlying mechanisms and implications for clinical management should be considered to provide individuals with the safest care possible. In this review, we provide an overview of different types of allergic adverse reactions that can potentially occur after vaccination and individual vaccine components capable of causing the allergic adverse reactions. We present the incidence of allergic adverse reactions during clinical studies and through post-authorization and post-marketing surveillance and provide plausible causes of these reactions based on potential allergenic components present in several common vaccines. Additionally, we review implications for individual diagnosis and management and vaccine manufacturing overall. Finally, we suggest areas for future research.</p

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M&gt;70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0&lt;e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level