Lipase catalyzed kinetic resolution of <img src='/image/spc_char/alpha.gif' border=0> -phenyl-2-nitroalcohols

1961-1965It has been demonstrated that optically pure (S)--phenyl-2-nitroalcohols can be efficiently prepared by kinetic resolution of the corresponding 2-nitroalcohols involving amino lipase from Pseudomonas fluorescens. In the case of -phenyl-2-nitroalcohols, the corresponding (R)-acetates are also obtained in good optical and chemical yield along with the (S)-alcohols