Effects of multicomponent exercise training on physical functioning among institutionalized elderly

This quasiexperimental study aimed to measure the effects of 12-week multicomponent exercise training on physical functioning among institutionalized elderly. Forty-three participants (age = 70.88 ± 7.82 years) were self-assigned to an intervention (n=23) or control (n=20) group. Before and after training, cardiorespiratory endurance, arm curl strength, grip strength, lower limb strength, upper and lower limb flexibility, balance, and mobility were assessed. The training included aerobic, resistance, balance and flexibility exercises, performed 3 times per week. Significant increases (P0.05) The control group did not show any significant changes (P>0.05) in any variables. The data suggested that 12-week multicomponent exercise training may improve physical functioning among institutionalized elderly

Reliability and preliminary reference values for the Total Faulty Breathing Scale (TFBS): A cross-sectional study

Background and Aims: The evaluation of breathing function is crucial in the clinical examination of the respiratory system. The Total Faulty Breathing Scale (TFBS) could be used in clinical settings to quantify the measurement of breathing dysfunction. Reliability data for the TFBS are available for males, but there is a requirement to determine reliability for females and to develop reference values. The aim of this study, therefore, was to determine the reliability in females and to establish the preliminary reference values for the TFBS. Methods: Twenty‐three healthy female participants for reliability and 44 (7 male and 37 female) participants for preliminary reference values participated in this cross‐sectional study. For both aspects of the study, participants were instructed to breathe at their own pace with no specific instruction. Then each participant was observed carrying out normal breathing for a period of 10 breaths and deep breathing for a period of 10 breaths while being assessed with the TFBS. Results: Intrarater and interrater reliability of the TFBS showed a kappa value of 0.769 and 0.751, respectively, indicating substantial agreement for female participants. The preliminary reference categories for TFBS were reported to be normal for 20 (45.5%) participants and mild faulty breathing for the remaining 24 (54.4%) participants. Conclusions: The findings of this study suggested that TFBS was reliable to measure breathing function among female participants, and the reference categories may be helpful in the identification of normal and faulty breathing

A new electro-generated o-dianisidine derivative stabilized MWCNT-modified GCE for low potential gallic acid

The exploration of functional group interactions and electro-generated species stabilization on chemically modified electrodes for efficient electro-analytical application is a continuing research area in electrochemistry. In addition, the electrochemical behaviours of the intermediate species, which are generated from the aromatic organic redox mediator and possess both methoxy and amine functional groups, have been rarely studied for electro-analytical applications. For the first time, we report the stabilization of an electro-generated enone derivative of the o-dianisidine (EDo-D) dimer formed as one of the intermediate species during o-dianisidine immobilization. The electro-generated o-dianisidine derivative (o-DD)-stabilized multi-walled carbon nanotube (MWCNT)-modified glassy carbon electrode (GCE/o-DD@MWCNT) exhibited two highly reproducible and, well-defined surface-confined redox couples in a pH 7 phosphate buffer solution (PBS). FTIR analyses indicated the presence of an amine group linkage and an azo product in the o-DD@MWCNT hybrid. UV-Vis and GC-MS analyses confirmed the presence of o-dianisidine in its azo dimer form within the MWCNT. In addition, the enone derivative of the o-dianisidine dimer present on the GCE/o-DD@MWCNT successfully sensed gallic acid (GA) at 0.16 V vs. Ag/AgCl in pH 7 PBS. Highly selective GA detection was achieved with a sensitivity of 0.4580 µA µM-1, a detection range of 100-1300 µM and a detection limit of 144 nM using chronoamperometry. GCE/o-DD@MWCNT also demonstrated effective GA detection in simulated real grape juice and water samples

Classification of SARS-CoV-2 and Non-SARS-CoV-2 Using Machine Learning Algorithms

Due to the continued evolution of the SARS-CoV-2 pandemic, researchers worldwide are working to mitigate, suppress its spread, and better understand it by deploying digital signal processing (DSP) and machine learning approaches. This study presents an alignment-free approach to classify the SARS-CoV-2 using complementary DNA, which is DNA synthesized from the single-stranded RNA virus. Herein, a total of 1582 samples, with different lengths of genome sequences from different regions, were collected from various data sources and divided into a SARS-CoV-2 and a non-SARS-CoV-2 group. We extracted eight biomarkers based on three-base periodicity, using DSP techniques, and ranked those based on a filter-based feature selection. The ranked biomarkers were fed into k-nearest neighbor, support vector machines, decision trees, and random forest classifiers for the classification of SARS-CoV-2 from other coronaviruses. The training dataset was used to test the performance of the classifiers based on accuracy and F-measure via 10-fold cross-validation. Kappa-scores were estimated to check the influence of unbalanced data. Further, 10x10 cross-validation paired t-test was utilized to test the best model with unseen data. Random forest was elected as the best model, differentiating the SARS-CoV-2 coronavirus from other coronaviruses and a control a group with an accuracy of 97.4%, sensitivity of 96.2%, and specificity of 98.2%, when tested with unseen samples. Moreover, the proposed algorithm was computationally efficient, taking only 0.31 seconds to compute the genome biomarkers, outperforming previous studies

Impact of Aerobic and Strengthening Exercise on Quality of Life (QOL), Mental Health and Physical Performance of Elderly People Residing at Old Age Homes

Background: The COVID-19 infection spread rapidly in Malaysia, and elderly people with underlying comorbidities were affected most. The study aimed to determine the effect of exercise on QOL and mental health among elderly people residing in old age homes during the COVID-19 pandemic. Methods: Out of 178 older adults from old age homes in Kedah and Penang States, 39 respondents undertook aerobic and strengthening exercises. A single group pre-test and post-test study was conducted in one government home and nine private homes in the northern region of Malaysia. The DASS-21 scale was used to assess mental health, and the WHOQOL-BREF questionnaire was used to evaluate QOL. Results: After 12 weeks of the exercise programme, scores for the physical domain increased from 53.1 to 61.8, for the psychological domain from 51.8 to 59.3, for the social domain from 53.2 to 60.5 and for the environmental domain from 67.2 to 72.1. Moreover, there was a significant reduction in the depression score from 6.2 to 4.4, the anxiety score from 3.5 to 2.2 and the stress score, from 4.6 to 2.8. Conclusion: Performing aerobic and strengthening exercises for a minimum of 12 weeks may have helped to improve mental health among the elderly during the COVID-19 pandemic, and it may also improve the quality of life for those who are residing in old age homes

Impact of Aerobic and Strengthening Exercise on Quality of Life (QOL), Mental Health and Physical Performance of Elderly People Residing at Old Age Homes

Background: The COVID-19 infection spread rapidly in Malaysia, and elderly people with underlying comorbidities were affected most. The study aimed to determine the effect of exercise on QOL and mental health among elderly people residing in old age homes during the COVID-19 pandemic. Methods: Out of 178 older adults from old age homes in Kedah and Penang States, 39 respondents undertook aerobic and strengthening exercises. A single group pre-test and post-test study was conducted in one government home and nine private homes in the northern region of Malaysia. The DASS-21 scale was used to assess mental health, and the WHOQOL-BREF questionnaire was used to evaluate QOL. Results: After 12 weeks of the exercise programme, scores for the physical domain increased from 53.1 to 61.8, for the psychological domain from 51.8 to 59.3, for the social domain from 53.2 to 60.5 and for the environmental domain from 67.2 to 72.1. Moreover, there was a significant reduction in the depression score from 6.2 to 4.4, the anxiety score from 3.5 to 2.2 and the stress score, from 4.6 to 2.8. Conclusion: Performing aerobic and strengthening exercises for a minimum of 12 weeks may have helped to improve mental health among the elderly during the COVID-19 pandemic, and it may also improve the quality of life for those who are residing in old age homes

New real-time force monitoring device with enhanced accuracy for evaluation of applied force during the joint mobilization technique

BACKGROUND: Force Monitoring Devices (FMDs) reported in the literature to monitor applied force during Joint Mobilization Technique (JMT) possess complex design/bulky which alters the execution of treatment, has poor accuracy and is unable to feel the resistance provided by soft tissues limits its usage in the clinical settings. OBJECTIVES: This study aims to develop a highly accurate, portable FMD and to demonstrate real-time monitoring of force applied by health professionals during JMT without altering its execution. METHODS: The FMD was constructed using the FlexiForce sensor, potential divider, ATmega 328 microcontroller, custom-written software, and liquid crystal display. The calibration, accuracy, and cyclic repeatability of the FMD were tested from 0 to 90 N applied load with a gold standard universal testing machine. For practical demonstration, the FMD was tested for monitoring applied force by a physiotherapist while performing Maitland's grade I to IV over the 6th cervical vertebra among 30 healthy subjects. RESULTS: The obtained Bland-Altman plot limits agreement for accuracy, and cyclic repeatability was -1.57 N to 1.22 N, and -1.26 N to 1.26 N, respectively with standard deviation and standard error of the mean values of 3.77% and 0.73% and 2.15% and 0.23%, respectively. The test-retest reliability of the FMD tested by the same researcher at an interval of one week showed an excellent intra-class correlation coefficient of r= 1.00. The obtained force readings for grade I to IV among 30 subjects ranged from 10.33 N to 45.24 N. CONCLUSIONS: Appreciable performance of the developed FMD suggested that it may be useful to monitor force applied by clinicians during JMT among neck pain subjects and is a useful educational tool for academicians to teach mobilization skills