-2)

Abstract Different liquisolid formulations of carbamazepine were accomplished by dissolving the drug in the non-toxic hydrophilic liquids, and adsorbing the solution onto the surface of silica. In order to reduce the amounts of carrier and aerosil in liquisolid formulations, some additives namely polyvinylpyrrolidone (PVP), hydroxypropyle methylcellulose (HPMC) and polyethylene glycol (PEG 35000) were added to liquid medication to increase loading factor. The effects of various ratios of carrier to coating material, PVP concentration, effect of aging and type of the carrier on dissolution rate of liquisolid compacts were studied. X-ray crystallography and differential scanning calorimetery (DSC) were used for evaluation of physicochemical properties of carbamazepine in liquisolid formulations. The results showed that the drug loading factor was increased significantly in the presence of additives. Liquisolid formulations containing PVP as additive, exhibited significantly higher drug dissolution rates compared to the compacts prepared by the direct compression technique. It was shown that microcrystalline cellulose had more liquid retention potential in comparison with lactose, and the formulations containing microcrystalline cellulose as carrier, showed higher dissolution rate. By decreasing the ratio of microcrystalline cellulose to silica from 20 to 10, an improvement in dissolution rate was observed. Further decrease in the ratio of microcrystalline cellulose:silica from 10 to 5 resulted in a significant reduction in dissolution rate. Increasing of PVP concentration in liquid medication caused a dramatic increase in dissolution rate at first 30 min. The results showed that the dissolution rate of liquisolid tablets was not significantly affected by storing the tablets at 25 • C/75% relative humidity for a period of 6 months. The results of DSC and X-ray crystallography did not show any changes in crystallinity of the drug and interaction between carbamazepine and exipients during the process

Push-out bond strength of quartz fibre posts to root canal dentin using total-etch and self-adhesive resin cements

Objectives: Several adhesive systems are available for cementation of fibre posts into the root canal. The aim of the present study was to investigate the push-out bond strengths of quartz fibre posts to root dentin with the use of different total-etch and self-adhesive resin cements. Study Design: Ninety single-rooted human premolars were endodontically treated and standardized post-spaces were prepared. Fibre posts were cemented with different luting agents: total-etch (Nexus NX3, Duo-Link, and RelyX ARC) and self-adhesive resin cements (Maxcem Elite, BisCem, and RelyX Unicem). Three post/dentin sections (coronal, middle and apical) were obtained from each specimen, and push-out bond strength test was performed in each section at a cross-head speed of 0.5 mm/min. Data was analyzed with two-factor and one-way analysis of variance and a post-hoc Tukey test at a significance level of p < 0.05. Results: Cement type, canal region, and their interaction significantly influenced bond strength. Significantly higher bond strength values were observed in the apical region of self-adhesive cements. Only Duo-Link and RelyX ARC cements resulted in homogeneous bond strengths. Conclusions: Cementation of quartz fibre posts using self-adhesive cements provided higher push-out bond strengths especially in the apical region, while total-etch cements resulted in more uniform bond strengths in different regions of the root canal. © Medicina Oral

Effect of surface treatment with sandblasting and Er,Cr:YSGG laser on bonding of stainless steel orthodontic brackets to silver amalgam

Objectives: Satisfactory bonding of orthodontic attachments to amalgam is a challenge for orthodontists. The aim of this in vitro study was to compare the shear bond strength of stainless steel orthodontic brackets to silver amalgam treated with sandblasting and Er,Cr:YSGG laser. Study Design: Fifty-four amalgam discs were prepared, polished and divided into three groups: In group 1 (the control group) the premolar brackets were bonded using Panavia F resin cement without any surface treatment; in groups 2 and 3, the specimens were subjected to sandblasting and Er,Cr:YSGG laser respectively, before bracket bonding. After immersing in distilled water at 37°C for 24 hours, all the specimens were tested for shear bond strength. Bond failure sites were evaluated under a stereomicroscope. Data was analyzed using one-way ANOVA and a post hoc Tukey test. Results: The highest and lowest shear bond strength values were recorded in the laser and control groups, respectively. There were significant differences in mean shear bond strength values between the laser and the other two groups (p<0.05). However, there were no significant differences between the sandblast and control groups (p=0.5). Conclusions: Amalgam surface treatment with Er,Cr:YSGG laser increased shear bond strength of stainless steel orthodontic brackets. © Medicina Oral

Effect of 10% Sodium Ascorbate on Bleached Bovine Enamel Surface Morphology and Microhardness

Sodium ascorbate has recently been suggested to compensate decreased bond strength of composite resin to bleached tooth surfaces. The aim of present study was to evaluate the effect of 10% sodium ascorbate on bleached bovine enamel morphology and microhardness considering the possibility of its effect on enamel surface characteristics. A total of 69 bovine enamel slabs were prepared and mounted in acrylic resin. Subsequent to polishing, they were randomly divided into 3 groups of 23 specimens each; 3 for Scanning Electron Microscopy (SEM) analysis and 20 for hardness test. In group 1 the specimens were immersed in distilled water as control group; in group 2 the specimens were bleached with 35% carbamide peroxide for 30 min a week for 3 consecutive weeks; and in group 3 the specimens were exposed to 10% sodium ascorbate for 30 min subsequent to bleaching similar to group 1. After 3 weeks Vickers hardness of the specimens was measured at 3 points with equal distances from each other under a force of 50 g. The mean of the hardness values of each specimen was calculated and data was analyzed by one-way ANOVA (P < 0.05). The highest and lowest microhardness values were observed in group 1 and group 2, respectively. However, there were no statistically significant differences in microhardness between the groups (P = 0.12). The use of 35% carbamide peroxide alone or with 10% sodium ascorbate does not affect bovine enamel hardness. SEM analysis showed a network of sodium ascorbate adsorbed to the bleached enamel surface

Effect of pre-heating on the mechanical properties of silorane-based and methacrylate-based composites

Background: The use of composites in dental restoration has been commonly criticized, due to their underwhelming mechanical properties. This problem may be solved partially by preheating. The present research aims to determine the effect of preheating on the mechanical properties of two different classes of composites. Material and Methods: A Silorane-based (Silorane) and a Methacrylate-based (Z250) composite were preheated to different temperatures (25, 37, and 68 °C) and afterwards were tested with the appropriate devices for each testing protocol. The materialâ s flexural strength, elastic modulus, and Vickers microhardness were evaluated. Two-way ANOVA, and Tukeyâ s post hoc were used to analyze the data. Results: Microhardness and elastic modulus increased with preheating, while flexural strength values did not increase significantly with preheating. Furthermore the methacrylate-based composite (Z250) showed higher values compared to the Silorane-based composite (Silorane) in all the tested properties. Conclusions: Preheating Silorane enhances the compositeâ s microhardness and elastic modulus but does not affect its flexural strength. On the other hand, preheating Z250 increases its microhardness but does not change its flexural strength or elastic modulus. In addition, the Z250 composite shows higher microhardness and flexural strength than Silorane, but the elastic modulus values with preheating are similar. Therefore Z250 seems to have better mechanical properties making it the better choice in a clinical situation

The effect of pre-heating on monomer elution from bulk-fill resin composites

The present study was aimed to evaluate the effect of pre-heating of bulk -fill resin composites on monomer elution from them. Three different types of resin composites were used including Tetric N-Ceram Bulk Fill, X-tra Fill and X-tra Base. 10 cylindrical samples were prepared from each resin composites. Before light curing, 5 samples were pre-heated until reaching 68?C, then 5 other samples were polymerized at room temperature. After 24 hours, release of UDMA, TEGDMA and BIS-GMA monomers were measured by High-Performance Liquid Chromatography analysis. Data analysis was performed by two-way ANOVA test, Games-Howell and Sidak post hoc tests. Pre-heating did not have any statistically significant effect on the mean values of UDMA, TEGDMA and Bis-GMA elution (p>0.05). The greatest amount of released Bis-GMA and UDMA was obtained from Tetric N-Ceram Bulk-fill composite. The greatest amount of released TEGDMA was obtained from X-tra Fill composite. X-tra Base composite showed the lowest amount of monomer release (P<0.001). Pre-heating did not have any effect on monomer release from bulk-fill resin composites. Moreover, the amount and the type of monomers released from various bulk-fill resin composites were not similar

The effect of repeated preheating of dimethacrylate and silorane-based composite resins on marginal gap of class V restorations

Background. One of the problems with composite resin restorations is gap formation at resin‒tooth interface. The present study evaluated the effect of preheating cycles of silorane- and dimethacrylate-based composite resins on gap formation at the gingival margins of Class V restorations. Methods. In this in vitro study, standard Class V cavities were prepared on the buccal surfaces of 48 bovine incisors. For restorative procedure, the samples were randomly divided into 2 groups based on the type of composite resin (group 1: di-methacrylate composite [Filtek Z250]; group 2: silorane composite [Filtek P90]) and each group was randomly divided into 2 subgroups based on the composite temperature (A: room temperature; B: after 40 preheating cycles up to 55°C). Marginal gaps were measured using a stereomicroscope at ×40 and analyzed with two-way ANOVA. Inter- and intra-group comparisons were analyzed with post-hoc Tukey tests. Significance level was defined at P < 0.05. Results. The maximum and minimum gaps were detected in groups 1-A and 2-B, respectively. The effects of composite resin type, preheating and interactive effect of these variables on gap formation were significant (P<0.001). Post-hoc Tukey tests showed greater gap in dimethacrylate compared to silorane composite resins (P< 0.001). In each group, gap values were greater in composite resins at room temperature compared to composite resins after 40 preheating cycles (P<0.001). Conclusion. Gap formation at the gingival margins of Class V cavities decreased due to preheating of both composite re-sins. Preheating of silorane-based composites can result in the best marginal adaptation

Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine)

Different liquisolid formulations of carbamazepine were accomplished by dissolving the drug in the non-toxic hydrophilic liquids, and adsorbing the solution onto the surface of silica. In order to reduce the amounts of carrier and aerosil in liquisolid formulations, some additives namely polyvinylpyrrolidone (PVP), hydroxypropyle methylcellulose (HPMC) and polyethylene glycol (PEG 35000) were added to liquid medication to increase loading factor. The effects of various ratios of carrier to coating material, PVP concentration, effect of aging and type of the carrier on dissolution rate of liquisolid compacts were studied. X-ray crystallography and differential scanning calorimetery (DSC) were used for evaluation of physicochemical properties of carbamazepine in liquisolid formulations. The results showed that the drug loading factor was increased significantly in the presence of additives. Liquisolid formulations containing PVP as additive, exhibited significantly higher drug dissolution rates compared to the compacts prepared by the direct compression technique. It was shown that microcrystalline cellulose had more liquid retention potential in comparison with lactose, and the formulations containing microcrystalline cellulose as carrier, showed higher dissolution rate. By decreasing the ratio of microcrystalline cellulose to silica from 20 to 10, an improvement in dissolution rate was observed. Further decrease in the ratio of microcrystalline cellulose: silica from 10 to 5 resulted in a significant reduction in dissolution rate. Increasing of PVP concentration in liquid medication caused a dramatic increase in dissolution rate at first 30 min. The results showed that the dissolution rate of liquisolid tablets was not significantly affected by storing the tablets at 25 degrees C/75% relative humidity for a period of 6 months. The results of DSC and X-ray crystallography did not show any changes in crystallinity of the drug and interaction between carbamazepine and exipients during the process. (c) 2007 Elsevier B.V. All rights reserved

Cloud computing and trust evaluation: A systematic literature review of the state-of-the-art mechanisms

Cloud computing is a model to enable the convenient access to the network request for sharing the groups of configurable calculating resources. In this environment, confidences are insufficient for the customers to identify the trustworthy cloud service providers. Therefore, in this system, an important challenge is assessing the trustworthiness to enable the users for choosing the trustworthy resources in the cloud infrastructure. However, in the cloud environments, despite the significance of the trust mechanisms and methods, the comprehensive and systematic research and study about the background of the trust evaluation methods between the cloud providers is rare. Hence, in this paper, we analyzed the trust evaluation state of the art mechanisms which are used in the cloud environment so far. Also, we analyzed and compared them in terms of integrity, security, reliability, dependability, safety, dynamicity, confidentiality, scalability, and giving a suggestion for some future research. Also, this article displays a systematic literature review (SLR) on the trust evaluation mechanisms in the cloud environments up to the end of March 2017. We identified 224 articles, which are reduced to 28 primary ones through our article selection process. By presenting the state-of-the-art information and the challenges issues, this survey will directly support academics, researchers, and professionals in their understanding of changes in the trust evaluation mechanisms in the cloud environments. Keywords: Trust, Cloud computing, Cloud service, Cloud provider, Systematic literature revie