'Genealogical misfortunes': Achille Mbembe's (re-)writing of postcolonial Africa

In his latest work, Sortir de la grande nuit, the Cameroonian social theorist, Achille Mbembe nuances his description of the ontological status of the postcolonial African subject, which he had theorized extensively in his best-known text, On the Postcolony, and at the same time exploits the conceptual resources of a number of Jean-Luc Nancy’s lexical innovations. This recent text is also a reprise of an earlier autobiographical essay, and the gesture of this ‘reinscription’ is critical to our understanding of Mbembe’s status as a contemporary ‘postcolonial thinker’, and the way in which he positions himself within a certain intellectual genealogy of postcolonial theory. Within this trajectory, I argue that we can read fruitfully his relationship to three influential figures: Jacques Derrida, Jean-Luc Nancy and Ruben Um Nyobè

Fixed and Flexible Rates: A Renewal of The Debate

The paper reviews the extent to which a decade of analysis and experience has altered thinking about the choice of an exchange rate system. The advantages of flexible rates are viewed to have been exaggerated. They do not permit governments to have permanently higher rates of economic activity at the expense of higher inflation as some thought. Further, the slow speed of adjustment to relative price changes limits the contribution of flexible rates to external adjustment in the short-run, and the degree of insulation from external influences that they provide. Finally, flexible rates tend to be fluctuating rates, and, although there is little empirical evidence so far showing that the fluctuations have had adverse effects on trade and capital flows, the exchange rate instability more than any other factor has led to a certain disillusionment with the floating rate system. Notwithstanding the drawbacks of flexible rates, there will be a continuing need for exchange rate flexibility over the next few years, and some analysis is given of the problems of achieving greater stability under flexible rates or the requisite amount of flexibility under pegged rates.

Schwannomatosis of the Spinal Accessory Nerve: A Case Report.

Schwannomatosis is a distinct syndrome characterized by multiple peripheral nerve schwannomas that can be sporadic or familial in nature. Cases affecting the lower cranial nerves are infrequent. Here, the authors present a rare case of schwannomatosis affecting the left spinal accessory nerve. Upon genetic screening, an in-frame insertion at codon p.R177 of the Sox 10 gene was observed. There were no identifiable alterations in NF1, NF2, LZTR1, and SMARCB1. This case demonstrates a rare clinical presentation of schwannomatosis in addition to a genetic aberration that has not been previously reported in this disease context

Cavity induced vibration of flexible hydrofoils

The objective of this work is to investigate the influence of cavity-induced vibrations on the dynamic response and stability of a NACA66 hydrofoil at 8° angle of attack at Re=750 000 via combined experimental measurements and numerical simulations. The rectangular, cantilevered hydrofoil is assumed to be rigid in the chordwise direction, while the spanwise bending and twisting deformations are represented using a two-degrees-of-freedom structural model. The multiphase flow is modeled with an incompressible, unsteady Reynolds Averaged Navier–Stokes solver with the k–ω Shear Stress Transport (SST) turbulence closure model, while the phase evolutions are modeled with a mass-transport equation based cavitation model. The numerical predictions are compared with experimental measurements across a range of cavitation numbers for a rigid and a flexible hydrofoil with the same undeformed geometries. The results showed that foil flexibility can lead to: (1) focusing – locking – of the frequency content of the vibrations to the nearest sub-harmonics of the foil׳s wetted natural frequencies, and (2) broadening of the frequency content of the vibrations in the unstable cavitation regime, where amplifications are observed in the sub-harmonics of the foil natural frequencies. Cavitation was also observed to cause frequency modulation, as the fluid density, and hence fluid induced (inertial, damping, and disturbing) forces fluctuated with unsteady cavitation.The authors gratefully acknowledge Ms. Kelly Cooper (program manager) and the Office of Naval Research (ONR), for their financial support through Grant nos. N00014-11-1-0833 and N0014-12-C-0585, as well as ONR Global and Dr. Woei-Min Lin (program manager) through grant no. N62909-12-1-7076

Wave-averaged balance: a simple example

In the presence of inertia-gravity waves, the geostrophic and hydrostatic balance that characterises the slow dynamics of rapidly rotating, strongly stratified flows holds in a time-averaged sense and applies to the Lagrangian-mean velocity and buoyancy. We give an elementary derivation of this wave-averaged balance and illustrate its accuracy in numerical solutions of the three-dimensional Boussinesq equations, using a simple configuration in which vertically planar near-inertial waves interact with a barotropic anticylonic vortex. We further use the conservation of the wave-averaged potential vorticity to predict the change in the barotropic vortex induced by the waves

Scattering of swell by currents

The refraction of surface gravity waves by currents leads to spatial modulations in the wave field and, in particular, in the significant wave height. We examine this phenomenon in the case of waves scattered by a localised current feature, assuming (i) the smallness of the ratio between current velocity and wave group speed, and (ii) a swell-like, highly directional wave spectrum. We apply matched asymptotics to the equation governing the conservation of wave action in the four-dimensional position--wavenumber space. The resulting explicit formulas show that the modulations in wave action and significant wave height past the localised current are controlled by the vorticity of the current integrated along the primary direction of the swell. We assess the asymptotic predictions against numerical simulations using WAVEWATCH III for a Gaussian vortex. We also consider vortex dipoles to demonstrate the possibility of `vortex cloaking' whereby certain currents have (asymptotically) no impact on the significant wave height. We discuss the role of the ratio of the two small parameters characterising assumptions (i) and (ii) above and show that caustics are only significant for unrealistically large values of this ratio, corresponding to unrealistically narrow directional spectra

High-content live cell imaging with RNA probes: advancements in high-throughput antimalarial drug discovery

<p>Abstract</p> <p>Background</p> <p>Malaria, a major public health issue in developing nations, is responsible for more than one million deaths a year. The most lethal species, <it>Plasmodium falciparum</it>, causes up to 90% of fatalities. Drug resistant strains to common therapies have emerged worldwide and recent artemisinin-based combination therapy failures hasten the need for new antimalarial drugs. Discovering novel compounds to be used as antimalarials is expedited by the use of a high-throughput screen (HTS) to detect parasite growth and proliferation. Fluorescent dyes that bind to DNA have replaced expensive traditional radioisotope incorporation for HTS growth assays, but do not give additional information regarding the parasite stage affected by the drug and a better indication of the drug's mode of action. Live cell imaging with RNA dyes, which correlates with cell growth and proliferation, has been limited by the availability of successful commercial dyes.</p> <p>Results</p> <p>After screening a library of newly synthesized stryrl dyes, we discovered three RNA binding dyes that provide morphological details of live parasites. Utilizing an inverted confocal imaging platform, live cell imaging of parasites increases parasite detection, improves the spatial and temporal resolution of the parasite under drug treatments, and can resolve morphological changes in individual cells.</p> <p>Conclusion</p> <p>This simple one-step technique is suitable for automation in a microplate format for novel antimalarial compound HTS. We have developed a new <it>P. falciparum </it>RNA high-content imaging growth inhibition assay that is robust with time and energy efficiency.</p

Clinical Management of Congenital Hypogonadotropic Hypogonadism

The initiation and maintenance of reproductive capacity in humans is dependent on pulsatile secretion of the hypothalamic hormone GnRH. Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder that results from the failure of the normal episodic GnRH secretion, leading to delayed puberty and infertility. CHH can be associated with an absent sense of smell, also termed Kallmann syndrome, or with other anomalies. CHH is characterized by rich genetic heterogeneity, with mutations in >30 genes identified to date acting either alone or in combination. CHH can be challenging to diagnose, particularly in early adolescence where the clinical picture mirrors that of constitutional delay of growth and puberty. Timely diagnosis and treatment will induce puberty, leading to improved sexual, bone, metabolic, and psychological health. In most cases, patients require lifelong treatment, yet a notable portion of male patients (approximate to 10% to 20%) exhibit a spontaneous recovery of their reproductive function. Finally, fertility can be induced with pulsatile GnRH treatment or gonadotropin regimens in most patients. In summary, this review is a comprehensive synthesis of the current literature available regarding the diagnosis, patient management, and genetic foundations of CHH relative to normal reproductive development.Peer reviewe