1,076 research outputs found
Grass pollen immunotherapy induces Foxp3-expressing CD4(+)CD25(+) cells in the nasal mucosa
Evaluating Mood Changes in Response to Anthropogenic Noise with a Response-Slowing Task in Three Species of Zoo-housed Primates
In the zoo environment, anthropogenic noise is common as sound levels fluctuate due to visitors, construction, habitat design, and special events. In this study, changes in the mood of three species of zoo-housed primates in response to a loud annual event were evaluated with the response-slowing paradigm. In this paradigm, animals experiencing anxiety slow responses on simple cognitive tasks when emotional content is displayed. Following a previously validated approach, we measured latencies to touch potentially threatening (conspecific faces with directed gaze) and non-threatening (conspecific faces with averted gaze) images overlaid on a grey square, relative to neutral control images (grey squares only) on a touchscreen. In Experiment 1, four Japanese macaques (Macaca fuscata) were tested in two conditions: during a baseline (non-stressful) period and opportunistically during three days during which loud jets frequently flew overhead. Results indicated a significant effect of condition, with an increase in latency to touch images of conspecific faces relative to control images during the days of the loud event. In Experiment 2, chimpanzees (Pan troglodytes, n = 4) and western lowland gorillas (Gorilla gorilla gorilla, n = 2) were tested during the same loud event following a similar methodology. The results revealed subtle changes across conditions; however, this was likely driven by the apes increasing their response speed to face stimuli relative to control stimuli over time (habituation). These findings suggest that the macaques, but not the apes, underwent detectable affective changes during the loud event. With additional development, this relatively simple paradigm may be an effective and feasible way to evaluate real-time changes in the mood of zoo-housed animals
Lorentz violating kinematics: Threshold theorems
Recent tentative experimental indications, and the subsequent theoretical
speculations, regarding possible violations of Lorentz invariance have
attracted a vast amount of attention. An important technical issue that
considerably complicates detailed calculations in any such scenario, is that
once one violates Lorentz invariance the analysis of thresholds in both
scattering and decay processes becomes extremely subtle, with many new and
naively unexpected effects. In the current article we develop several extremely
general threshold theorems that depend only on the existence of some energy
momentum relation E(p), eschewing even assumptions of isotropy or monotonicity.
We shall argue that there are physically interesting situations where such a
level of generality is called for, and that existing (partial) results in the
literature make unnecessary technical assumptions. Even in this most general of
settings, we show that at threshold all final state particles move with the
same 3-velocity, while initial state particles must have 3-velocities
parallel/anti-parallel to the final state particles. In contrast the various
3-momenta can behave in a complicated and counter-intuitive manner.Comment: V1: 32 pages, 6 figures, 3 tables. V2: 5 references adde
Parallel gene synthesis in a microfluidic device
The ability to synthesize custom de novo DNA constructs rapidly, accurately and inexpensively is highly desired by researchers, as synthetic genes and longer DNA constructs are enabling to numerous powerful applications in both traditional molecular biology and the emerging field of synthetic biology. However, the current cost of de novo synthesis—driven largely by reagent and handling costs—is a significant barrier to the widespread availability of such technology. In this work, we demonstrate, to our knowledge, the first gene synthesis in a microfluidic environment. The use of microfluidic technology greatly reduces reaction volumes and the corresponding reagent and handling costs. Additionally, microfluidic technology enables large numbers of complex reactions to be performed in parallel. Here, we report the fabrication of a multi-chamber microfluidic device and its use in carrying out the syntheses of several DNA constructs. Genes up to 1 kb in length were synthesized in parallel at minute starting oligonucleotide concentrations (10–25 nM) in four 500 nl reactors. Such volumes are one to two orders of magnitude lower than those utilized in conventional gene synthesis. The identity of all target genes was verified by sequencing, and the resultant error rate was determined to be 1 per 560 bases.Massachusetts Institute of Technology. Center for Bits and AtomsNational Science Foundation (U.S.) (CBA grant CCR-0122419
Effective Theory Approach to the Spontaneous Breakdown of Lorentz Invariance
We generalize the coset construction of Callan, Coleman, Wess and Zumino to
theories in which the Lorentz group is spontaneously broken down to one of its
subgroups. This allows us to write down the most general low-energy effective
Lagrangian in which Lorentz invariance is non-linearly realized, and to explore
the consequences of broken Lorentz symmetry without having to make any
assumptions about the mechanism that triggers the breaking. We carry out the
construction both in flat space, in which the Lorentz group is a global
spacetime symmetry, and in a generally covariant theory, in which the Lorentz
group can be treated as a local internal symmetry. As an illustration of this
formalism, we construct the most general effective field theory in which the
rotation group remains unbroken, and show that the latter is just the
Einstein-aether theory.Comment: 45 pages, no figures
Spatially Explicit Data: Stewardship and Ethical Challenges in Science
Scholarly communication is at an unprecedented turning point created in part by the increasing saliency of data stewardship and data sharing. Formal data management plans represent a new emphasis in research, enabling access to data at higher volumes and more quickly, and the potential for replication and augmentation of existing research. Data sharing has recently transformed the practice, scope, content, and applicability of research in several disciplines, in particular in relation to spatially specific data. This lends exciting potentiality, but the most effective ways in which to implement such changes, particularly for disciplines involving human subjects and other sensitive information, demand consideration. Data management plans, stewardship, and sharing, impart distinctive technical, sociological, and ethical challenges that remain to be adequately identified and remedied. Here, we consider these and propose potential solutions for their amelioration
Stringy Stability of Charged Dilaton Black Holes with Flat Event Horizon
Electrically charged black holes with flat event horizon in anti-de Sitter
space have received much attention due to various applications in Anti-de
Sitter/Conformal Field Theory (AdS/CFT) correspondence, from modeling the
behavior of quark-gluon plasma to superconductor. Crucial to the physics on the
dual field theory is the fact that when embedded in string theory, black holes
in the bulk may become vulnerable to instability caused by brane
pair-production. Since dilaton arises naturally in the context of string
theory, we study the effect of coupling dilaton to Maxwell field on the
stability of flat charged AdS black holes. In particular, we study the
stability of Gao-Zhang black holes, which are locally asymptotically anti-de
Sitter. We find that for dilaton coupling parameter > 1, flat black
holes are stable against brane pair production, however for 0 < < 1,
the black holes eventually become unstable as the amount of electrical charges
is increased. Such instability however, behaves somewhat differently from that
of flat Reissner-Nordstr\"om black holes. In addition, we prove that the
Seiberg-Witten action of charged dilaton AdS black hole of Gao-Zhang type with
flat event horizon (at least in 5-dimension) is always logarithmically
divergent at infinity for finite values of , and is finite and positive
in the case tends to infinity . We also comment on the robustness of
our result for other charged dilaton black holes that are not of Gao-Zhang
type.Comment: Fixed some confusions regarding whether part of the discussions
concern electrically charged hole or magnetically charged one. No changes to
the result
A limited sampling strategy for estimation of the area under the curve (0 to 8 hours) of mycophenolic acid administered three times daily to liver transplant recipients
Rotating black holes with equal-magnitude angular momenta in d=5 Einstein-Gauss-Bonnet theory
We construct rotating black hole solutions in Einstein-Gauss-Bonnet theory in
five spacetime dimensions. These black holes are asymptotically flat, and
possess a regular horizon of spherical topology and two equal-magnitude angular
momenta associated with two distinct planes of rotation. The action and global
charges of the solutions are obtained by using the quasilocal formalism with
boundary counterterms generalized for the case of Einstein-Gauss-Bonnet theory.
We discuss the general properties of these black holes and study their
dependence on the Gauss-Bonnet coupling constant . We argue that most
of the properties of the configurations are not affected by the higher
derivative terms. For fixed the set of black hole solutions terminates
at an extremal black hole with a regular horizon, where the Hawking temperature
vanishes and the angular momenta attain their extremal values. The domain of
existence of regular black hole solutions is studied. The near horizon geometry
of the extremal solutions is determined by employing the entropy function
formalism.Comment: 25 pages, 7 figure
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