Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe

Review of: New Race Politics In America: Understanding Minority And Immigrant Politics edited by Jane Junn and Kerry L. Haynie

This article reviews the book New Race Politics In America: Understanding Minority And Immigrant Politics edited by Jane Junn and Kerry L. Haynie

The Politics of Belonging: Interest Group Identity and Agenda Setting on Immigration

This article explores how interest groups decide policy positions through case studies of three organizations’ shifting stances on the issue of immigration. In all three cases, the AFL-CIO, the Sierra Club, and the Christian Coalition, issue positions are signaling mechanisms central to the construction of an organizational identity. Leadership considers the message the stance on a policy issue sends to potential constituents and allies. Organizational agendas are one tool used by leaders to craft new narratives about what the group stands for, who the group represents, and who belongs. Key determinants of leaderships’ calculation over redrawing the boundaries of inclusion and representation and what signal an issue stance will convey includes organizational strength and a reading of a shifting political terrain. An evolutionary metaphor, instead of a rational actor model, is better suited to understand this critical component of interest group behavior, agenda setting