971 research outputs found
Spatially Explicit Data: Stewardship and Ethical Challenges in Science
Scholarly communication is at an unprecedented turning point created in part by the increasing saliency of data stewardship and data sharing. Formal data management plans represent a new emphasis in research, enabling access to data at higher volumes and more quickly, and the potential for replication and augmentation of existing research. Data sharing has recently transformed the practice, scope, content, and applicability of research in several disciplines, in particular in relation to spatially specific data. This lends exciting potentiality, but the most effective ways in which to implement such changes, particularly for disciplines involving human subjects and other sensitive information, demand consideration. Data management plans, stewardship, and sharing, impart distinctive technical, sociological, and ethical challenges that remain to be adequately identified and remedied. Here, we consider these and propose potential solutions for their amelioration
A single low-energy, iron-poor supernova as the source of metals in the star SMSS J 031300.36-670839.3
The element abundance ratios of four low-mass stars with extremely low
metallicities indicate that the gas out of which the stars formed was enriched
in each case by at most a few, and potentially only one low-energy, supernova.
Such supernovae yield large quantities of light elements such as carbon but
very little iron. The dominance of low-energy supernovae is surprising, because
it has been expected that the first stars were extremely massive, and that they
disintegrated in pair-instability explosions that would rapidly enrich galaxies
in iron. What has remained unclear is the yield of iron from the first
supernovae, because hitherto no star is unambiguously interpreted as
encapsulating the yield of a single supernova. Here we report the optical
spectrum of SMSS J031300.36- 670839.3, which shows no evidence of iron (with an
upper limit of 10^-7.1 times solar abundance). Based on a comparison of its
abundance pattern with those of models, we conclude that the star was seeded
with material from a single supernova with an original mass of ~60 Mo (and that
the supernova left behind a black hole). Taken together with the previously
mentioned low-metallicity stars, we conclude that low-energy supernovae were
common in the early Universe, and that such supernovae yield light element
enrichment with insignificant iron. Reduced stellar feedback both chemically
and mechanically from low-energy supernovae would have enabled first-generation
stars to form over an extended period. We speculate that such stars may perhaps
have had an important role in the epoch of cosmic reionization and the chemical
evolution of early galaxies.Comment: 28 pages, 6 figures, Natur
Comments on Holographic Entanglement Entropy and RG Flows
Using holographic entanglement entropy for strip geometry, we construct a
candidate for a c-function in arbitrary dimensions. For holographic theories
dual to Einstein gravity, this c-function is shown to decrease monotonically
along RG flows. A sufficient condition required for this monotonic flow is that
the stress tensor of the matter fields driving the holographic RG flow must
satisfy the null energy condition over the holographic surface used to
calculate the entanglement entropy. In the case where the bulk theory is
described by Gauss-Bonnet gravity, the latter condition alone is not sufficient
to establish the monotonic flow of the c-function. We also observe that for
certain holographic RG flows, the entanglement entropy undergoes a 'phase
transition' as the size of the system grows and as a result, evolution of the
c-function may exhibit a discontinuous drop.Comment: References adde
Wilsonian Approach to Fluid/Gravity Duality
The problem of gravitational fluctuations confined inside a finite cutoff at
radius outside the horizon in a general class of black hole geometries
is considered. Consistent boundary conditions at both the cutoff surface and
the horizon are found and the resulting modes analyzed. For general cutoff
the dispersion relation is shown at long wavelengths to be that of a
linearized Navier-Stokes fluid living on the cutoff surface. A cutoff-dependent
line-integral formula for the diffusion constant is derived. The
dependence on is interpreted as renormalization group (RG) flow in the
fluid. Taking the cutoff to infinity in an asymptotically AdS context, the
formula for reproduces as a special case well-known results derived
using AdS/CFT. Taking the cutoff to the horizon, the effective speed of sound
goes to infinity, the fluid becomes incompressible and the Navier-Stokes
dispersion relation becomes exact. The resulting universal formula for the
diffusion constant reproduces old results from the membrane
paradigm. Hence the old membrane paradigm results and new AdS/CFT results are
related by RG flow. RG flow-invariance of the viscosity to entropy ratio is shown to follow from the first law of thermodynamics together with
isentropy of radial evolution in classical gravity. The ratio is expected to
run when quantum gravitational corrections are included.Comment: 34 pages, harvmac, clarified boundary conditio
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The combined diabetes and renal control trial (C-DIRECT) - a feasibility randomised controlled trial to evaluate outcomes in multi-morbid patients with diabetes and on dialysis using a mixed methods approach
Background: This cluster randomised controlled trial set out to investigate the feasibility and acceptability of the “Combined Diabetes and Renal Control Trial” (C-DIRECT) intervention, a nurse-led intervention based on motivational interviewing and self-management in patients with coexisting end stage renal diseases and diabetes mellitus (DM ESRD). Its efficacy to improve glycaemic control, as well as psychosocial and self-care outcomes were also evaluated as secondary outcomes.
Methods: An assessor-blinded, clustered randomised-controlled trial was conducted with 44 haemodialysis patients with DM ESRD and ≥ 8% glycated haemoglobin (HbA1c), in dialysis centres across Singapore. Patients were randomised according to dialysis shifts. 20 patients were assigned to intervention and 24 were in usual care. The C-DIRECT intervention consisted of three weekly chair-side sessions delivered by diabetes specialist nurses. Data on recruitment, randomisation, and retention, and secondary outcomes such as clinical endpoints, emotional distress, adherence, and self-management skills measures were obtained at baseline and at 12 weeks follow-up. A qualitative evaluation using interviews was conducted at the end of the trial.
Results: Of the 44 recruited at baseline, 42 patients were evaluated at follow-up. One patient died, and one discontinued the study due to deteriorating health. Recruitment, retention, and acceptability rates of C-DIRECT were generally satisfactory HbA1c levels decreased in both groups, but C-DIRECT had more participants with HbA1c < 8% at follow up compared to usual care. Significant improvements in role limitations due to physical health were noted for C-DIRECT whereas levels remained stable in usual care. No statistically significant differences between groups were observed for other clinical markers and other patient-reported outcomes. There were no adverse effects.
Conclusions: The trial demonstrated satisfactory feasibility. A brief intervention delivered on bedside as part of routine dialysis care showed some benefits in glycaemic control and on QOL domain compared with usual care, although no effect was observed in other secondary outcomes. Further research is needed to design and assess interventions to promote diabetes self-management in socially vulnerable patients
Testis and Antler Dysgenesis in Sitka Black-Tailed Deer on Kodiak Island, Alaska: Sequela of Environmental Endocrine Disruption?
It had been observed that many male Sitka black-tailed deer (Odocoileus hemionus sitkensis) on Kodiak Island, Alaska, had abnormal antlers, were cryptorchid, and presented no evidence of hypospadias. We sought to better understand the problem and investigated 171 male deer for phenotypic aberrations and 12 for detailed testicular histopathology. For the low-lying Aliulik Peninsula (AP), 61 of 94 deer were bilateral cryptorchids (BCOs); 70% of these had abnormal antlers. Elsewhere on the Kodiak Archipelago, only 5 of 65 deer were BCOs. All 11 abdominal testes examined had no spermatogenesis but contained abnormalities including carcinoma in situ–like cells, possible precursors of seminoma; Sertoli cell, Leydig cell, and stromal cell tumors; carcinoma and adenoma of rete testis; and microlithiasis or calcifications. Cysts also were evident within the excurrent ducts. Two of 10 scrotal testes contained similar abnormalities, although spermatogenesis was ongoing. We cannot rule out that these abnormalities are linked sequelae of a mutation(s) in a founder animal, followed by transmission over many years and causing high prevalence only on the AP. However, based on lesions observed, we hypothesize that it is more likely that this testis–antler dysgenesis resulted from continuing exposure of pregnant females to an estrogenic environmental agent(s), thereby transforming testicular cells, affecting development of primordial antler pedicles, and blocking transabdominal descent of fetal testes. A browse (e.g., kelp) favored by deer in this locale might carry the putative estrogenic agent(s)
Generating Temperature Flow for eta/s with Higher Derivatives: From Lifshitz to AdS
We consider charged dilatonic black branes in AdS_5 and examine the effects
of perturbative higher derivative corrections on the ratio of shear viscosity
to entropy density eta/s of the dual plasma. The structure of eta/s is
controlled by the relative hierarchy between the two scales in the plasma, the
temperature and the chemical potential. In this model the background
near-horizon geometry interpolates between a Lifshitz-like brane at low
temperature, and an AdS brane at high temperatures -- with AdS asymptotics in
both cases. As a result, in this construction the viscosity to entropy ratio
flows as a function of temperature, from a value in the IR which is sensitive
to the dynamical exponent z, to the simple result expected for an AdS brane in
the UV. Coupling the scalar directly to the higher derivative terms generates
additional temperature dependence, and leads to a particularly interesting
structure for eta/s in the IR.Comment: Plots and references added. Journal version of the pape
Holographic c-theorems in arbitrary dimensions
We re-examine holographic versions of the c-theorem and entanglement entropy
in the context of higher curvature gravity and the AdS/CFT correspondence. We
select the gravity theories by tuning the gravitational couplings to eliminate
non-unitary operators in the boundary theory and demonstrate that all of these
theories obey a holographic c-theorem. In cases where the dual CFT is
even-dimensional, we show that the quantity that flows is the central charge
associated with the A-type trace anomaly. Here, unlike in conventional
holographic constructions with Einstein gravity, we are able to distinguish
this quantity from other central charges or the leading coefficient in the
entropy density of a thermal bath. In general, we are also able to identify
this quantity with the coefficient of a universal contribution to the
entanglement entropy in a particular construction. Our results suggest that
these coefficients appearing in entanglement entropy play the role of central
charges in odd-dimensional CFT's. We conjecture a new c-theorem on the space of
odd-dimensional field theories, which extends Cardy's proposal for even
dimensions. Beyond holography, we were able to show that for any
even-dimensional CFT, the universal coefficient appearing the entanglement
entropy which we calculate is precisely the A-type central charge.Comment: 62 pages, 4 figures, few typo's correcte
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Sodium and Health: Old Myths and a Controversy Based on Denial
Purpose of Review
The scientific consensus on which global health organizations base public health policies is that high sodium intake increases blood pressure (BP) in a linear fashion contributing to cardiovascular disease (CVD). A moderate reduction in sodium intake to 2000 mg per day helps ensure that BP remains at a healthy level to reduce the burden of CVD.
Recent Findings
Yet, since as long ago as 1988, and more recently in eight articles published in the European Heart Journal in 2020 and 2021, some researchers have propagated a myth that reducing sodium does not consistently reduce CVD but rather that lower sodium might increase the risk of CVD. These claims are not well-founded and support some food and beverage industry’s vested interests in the use of excessive amounts of salt to preserve food, enhance taste, and increase thirst. Nevertheless, some researchers, often with funding from the food industry, continue to publish such claims without addressing the numerous objections. This article analyzes the eight articles as a case study, summarizes misleading claims, their objections, and it offers possible reasons for such claims.
Summary
Our study calls upon journal editors to ensure that unfounded claims about sodium intake be rigorously challenged by independent reviewers before publication; to avoid editorial writers who have been co-authors with the subject paper’s authors; to require statements of conflict of interest; and to ensure that their pages are used only by those who seek to advance knowledge by engaging in the scientific method and its collegial pursuit. The public interest in the prevention and treatment of disease requires no less
Comparison of embedded and added motor imagery training in patients after stroke: Study protocol of a randomised controlled pilot trial using a mixed methods approach
Copyright @ 2009 Schuster et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Background: Two different approaches have been adopted when applying motor imagery (MI) to stroke patients. MI can be conducted either added to conventional physiotherapy or integrated within therapy sessions. The proposed study aims to compare the efficacy of embedded MI to an added MI intervention. Evidence from pilot studies reported in the literature suggests that both approaches can improve performance of a complex motor skill involving whole body movements, however, it remains to be demonstrated, which is the more effective one.Methods/Design: A single blinded, randomised controlled trial (RCT) with a pre-post intervention design will be carried out. The study design includes two experimental groups and a control group (CG). Both experimental groups (EG1, EG2) will receive physical practice of a clinical relevant motor task ('Going down, laying on the floor, and getting up again') over a two week intervention period: EG1 with embedded MI training, EG2 with MI training added after physiotherapy. The CG will receive standard physiotherapy intervention and an additional control intervention not related to MI.The primary study outcome is the time difference to perform the task from pre to post-intervention. Secondary outcomes include level of help needed, stages of motor task completion, degree of motor impairment, balance ability, fear of falling measure, motivation score, and motor imagery ability score. Four data collection points are proposed: twice during baseline phase, once following the intervention period, and once after a two week follow up. A nested qualitative part should add an important insight into patients' experience and attitudes towards MI. Semi-structured interviews of six to ten patients, who participate in the RCT, will be conducted to investigate patients' previous experience with MI and their expectations towards the MI intervention in the study. Patients will be interviewed prior and after the intervention period.Discussion: Results will determine whether embedded MI is superior to added MI. Findings of the semi-structured interviews will help to integrate patient's expectations of MI interventions in the design of research studies to improve practical applicability using MI as an adjunct therapy technique
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