Availability of coal resources in Illinois : Mt. Carmel Quadrangle, southeastern Illinois

"Department of Natural Resources, Illinois State Geological Survey"--Cover.Includes bibliographical references (p. 38-39)

The Iowa Homemaker vol.3, no.8

Table of Contents The Goal of Home Management Courses at Iowa State by Ruth M. Lindquist, page 3 Home Economics Venture Upon “India’s Coral Strand” by Marcia E. Turner, page 4 The Bell Recipe File by Opal Wind, page 4 Carving the Turkey by Viola M. Bell, page 5 An Interview With Scottish Hockey Coach by Lucile Barta, page 5 Two and One-half Miles Saved a Day by Grata Thorne, page 6 Cranberries for Thanksgiving by Katherine Goeppinger, page 7 Who is Responsible for the Child - by “A Bachelor”, page 8 The Evolution of Home Economics at Iowa State by Ruth Elaine Wilson, page 9 Why is a Mulligan? by “Joe Baggs”, page 10 Turning the Corners Up by Laura E. Bublitz, page 10 The Sport of Amateur Housekeeping by Anna Jacobson, page 11 Who’s There and Where by Helen I. Putnam, page 12 Dressing the Homemaker by Margaret Dix, page 1

Regulation and Function of the Interleukin 13 Receptor α 2 During a T Helper Cell Type 2–dominant Immune Response

Highly polarized type 2 cytokine responses can be harmful and even lethal to the host if they are too vigorous or persist too long. Therefore, it is important to elucidate the mechanisms that down-regulate these reactions. Interleukin (IL)-13 has emerged as a central mediator of T helper cell (Th)2-dominant immune responses, exhibiting a diverse array of functional activities including regulation of airway hyperreactivity, resistance to nematode parasites, and tissue remodeling and fibrosis. Here, we show that IL-13 receptor (R)α2 is a critical down-regulatory factor of IL-13–mediated tissue fibrosis induced by the parasitic helminth Schistosoma mansoni. IL-13Rα2 expression was induced after the onset of the fibrotic response, IL-10, IL-13, and Stat6 dependent, and inhibited by the Th1-inducing adjuvant IL-12. Strikingly, schistosome-infected C57BL/6 and BALB/c IL-13Rα2–deficient mice showed a marked exacerbation in hepatic fibrosis, despite displaying no change in granuloma size, tissue eosinophilia, or mastocytosis. Fibrosis increased despite the fact that IL-13 levels decreased significantly in the liver and serum. Importantly, pathology was prevented when IL-13Rα2–deficient mice were treated with a soluble IL-13Rα2-Fc construct, formally demonstrating that their exacerbated fibrotic response was due to heightened IL-13 activity. Together, these studies illustrate the central role played by the IL-13Rα2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response

An ancient founder mutation in PROKR2 impairs human reproduction

Congenital gonadotropin-releasing hormone (GnRH) deficiency manifests as absent or incomplete sexual maturation and infertility. Although the disease exhibits marked locus and allelic heterogeneity, with the causal mutations being both rare and private, one causal mutation in the prokineticin receptor, PROKR2 L173R, appears unusually prevalent among GnRH-deficient patients of diverse geographic and ethnic origins. To track the genetic ancestry of PROKR2 L173R, haplotype mapping was performed in 22 unrelated patients with GnRH deficiency carrying L173R and their 30 first-degree relatives. The mutation's age was estimated using a haplotype-decay model. Thirteen subjects were informative and in all of them the mutation was present on the same ∼123 kb haplotype whose population frequency is ≤10%. Thus, PROKR2 L173R represents a founder mutation whose age is estimated at approximately 9000 years. Inheritance of PROKR2 L173R-associated GnRH deficiency was complex with highly variable penetrance among carriers, influenced by additional mutations in the other PROKR2 allele (recessive inheritance) or another gene (digenicity). The paradoxical identification of an ancient founder mutation that impairs reproduction has intriguing implications for the inheritance mechanisms of PROKR2 L173R-associated GnRH deficiency and for the relevant processes of evolutionary selection, including potential selective advantages of mutation carriers in genes affecting reproductio

Blueprint for Creating a Community of Care and Support for People with Serious Illness

There is growing awareness nationwide about the importance of care during serious illness and at endof-life.2 The Institute of Medicine (IOM) Report, Dying in America, released in 2014, recommends a person-centered, family-oriented approach that honors individual preferences and promotes quality of life. The IOM Report emphasizes that implementing this vision is a matter of national priority and urgency. In Whatcom County, there is a rising tide of initiatives, interest, and excitement about the idea of creating a community of excellence for people with serious illness. Whatcom County has supported a successful Hospice and inpatient palliative care service for a number of years, and we enjoy a community-wide culture of collaboration that has spawned a university-based institute for palliative care. The NWLP Coalition Task Force was established in 2014 and developed a blueprint that articulates a coherent vision and a plan for collaborative community action toward achieving community excellence for end-of-life care. The original Task Force produced five White Papers that helped inform the original Blueprint. Posted on the WAHA website, the papers cover the following topics: Advance Care Planning; Palliative Care; Community Culture; Provider Training; and Financing the Future. The 2014 Blueprint provided brief background statements for each of these topics, along with keys to excellence, community assets, and recommended steps toward realizing the Blueprint vision. Two years into implementation, the NWLP Coalition is issuing this revised blueprint. Under an expanded title that invites community excellence in “serious illness care” as well as end-of-life care, the Coalition is re-affirming the original vision, and revising the Blueprint with new recommendations that reflect projects completed and lessons learned as well as a set of aspirational community measures