The CaveUT system:Immersive entertainment based on a game engine

We describe recent developments in the CaveUT software, which supports immersive virtual reality installations based on the Unreal Tournament game engine. CaveUT implements several high-end VR features such as real-time stereoscopy with head and hand tracking. We demonstrate the use of CaveUT in the SAS Cube™, a PC-based CAVE™-like immersive four-screen display. One of the main advantages of the system is to support fully immersive VR while retaining the game engine’s advanced features for interaction and behavioral (or AI) systems. We illustrate the use of CaveUT on two installations: an artistic VR installation and an immersive interactive storytelling system

Peer Support through Community Building

This poster describes the progress and lessons learned as a result of newly implemented Faculty Mentoring Program in the IUPUI Herron School of Art and Design

Audit into the Appropriateness of CT Cervical Spine Scan Requesting in the Emergency Department

Introduction:  The use of computed tomography (CT) imaging of the cervical spine (CS) is now the recommended primary screening modality for suspected CS injuries following trauma. The aim of this audit is to review the appropriate use of CS CT imaging in the emergency department (ED) and assess compliance with the National Institute for Health and Care Excellence (NICE) head injury clinical guidelines.Methods: Charts were reviewed for the last 50 trauma patients to receive a CS CT scan following a request from the ED at University Hospital Limerick between 10 July 2013 and 19 December 2013. The NICE clinical guideline 176 on head injury was used as the standard of care. These data were used to perform a retrospective audit to assess patients who satisfied NICE criteria to qualify for a CS CT scan.Results: 45 patients who had undergone a CS CT scan were identified, this group had a mean age of 42 years and 71% of them were male. At least one of the NICE guideline criteria was fulfilled in 100% of patients who had a CS CT, with 2.64 of the criteria fulfilled on average. Plain-film X-ray radiography (PF) was inadequate for diagnosis in 20 (44.4%) patients.Discussion: ED consultants appropriately refer patients for CS CT scans following CS trauma and adhere to NICE head injury clinical guidelines.Conclusion: Having guidelines in place in the ED and adopting CS CT imaging as an initial screening modality following CS injury may reduce time to definitive care and improve resource implications

Lessons to be learned by comparing integrated fisheries stock assessment models (SAMs) with integrated population models (IPMs)

AEP was partially funded by the Cooperative Institute for Climate, Ocean, & Ecosystem Studies (CICOES) under NOAA Cooperative Agreement NA15OAR4320063, Contribution No. 2023-1331.Integrated fisheries stock assessment models (SAMs) and integrated population models (IPMs) are used in biological and ecological systems to estimate abundance and demographic rates. The approaches are fundamentally very similar, but historically have been considered as separate endeavors, resulting in a loss of shared vision, practice and progress. We review the two approaches to identify similarities and differences, with a view to identifying key lessons that would benefit more generally the overarching topic of population ecology. We present a case study for each of SAM (snapper from the west coast of New Zealand) and IPM (woodchat shrikes from Germany) to highlight differences and similarities. The key differences between SAMs and IPMs appear to be the objectives and parameter estimates required to meet these objectives, the size and spatial scale of the populations, and the differing availability of various types of data. In addition, up to now, typical SAMs have been applied in aquatic habitats, while most IPMs stem from terrestrial habitats. SAMs generally aim to assess the level of sustainable exploitation of fish populations, so absolute abundance or biomass must be estimated, although some estimate only relative trends. Relative abundance is often sufficient to understand population dynamics and inform conservation actions, which is the main objective of IPMs. IPMs are often applied to small populations of conservation concern, where demographic uncertainty can be important, which is more conveniently implemented using Bayesian approaches. IPMs are typically applied at small to moderate spatial scales (1 to 104 km2), with the possibility of collecting detailed longitudinal individual data, whereas SAMs are typically applied to large, economically valuable fish stocks at very large spatial scales (104 to 106 km2) with limited possibility of collecting detailed individual data. There is a sense in which a SAM is more data- (or information-) hungry than an IPM because of its goal to estimate absolute biomass or abundance, and data at the individual level to inform demographic rates are more difficult to obtain in the (often marine) systems where most SAMs are applied. SAMs therefore require more 'tuning' or assumptions than IPMs, where the 'data speak for themselves', and consequently techniques such as data weighting and model evaluation are more nuanced for SAMs than for IPMs. SAMs would benefit from being fit to more disaggregated data to quantify spatial and individual variation and allow richer inference on demographic processes. IPMs would benefit from more attempts to estimate absolute abundance, for example by using unconditional models for capture-recapture data.Publisher PDFPeer reviewe

Rapid, directed transport of DC-SIGN clusters in the plasma membrane

C-type lectins, including dendritic cell–specific intercellular adhesion molecule-3–grabbing nonintegrin (DC-SIGN), are all-purpose pathogen receptors that exist in nanoclusters in plasma membranes of dendritic cells. A small fraction of these clusters, obvious from the videos, can undergo rapid, directed transport in the plane of the plasma membrane at average speeds of more than 1 μm/s in both dendritic cells and MX DC-SIGN murine fibroblasts ectopically expressing DC-SIGN. Surprisingly, instantaneous speeds can be considerably greater. In MX DC-SIGN cells, many cluster trajectories are colinear with microtubules that reside close to the ventral membrane, and the microtubule-depolymerizing drug, nocodazole, markedly reduced the areal density of directed movement trajectories, suggesting a microtubule motor–driven transport mechanism; by contrast, latrunculin A, which affects the actin network, did not depress this movement. Rapid, retrograde movement of DC-SIGN may be an efficient mechanism for bringing bound pathogen on the leading edge and projections of dendritic cells to the perinuclear region for internalization and processing. Dengue virus bound to DC-SIGN on dendritic projections was rapidly transported toward the cell center. The existence of this movement within the plasma membrane points to an unexpected lateral transport mechanism in mammalian cells and challenges our current concepts of cortex-membrane interactions

Brain Activation During Working Memory Is Altered in Patients With Type 1 Diabetes During Hypoglycemia

OBJECTIVE To investigate the effects of acute hypoglycemia on working memory and brain function in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS Using blood oxygen level–dependent (BOLD) functional magnetic resonance imaging during euglycemic (5.0 mmol/L) and hypoglycemic (2.8 mmol/L) hyperinsulinemic clamps, we compared brain activation response to a working-memory task (WMT) in type 1 diabetic subjects (n = 16) with that in age-matched nondiabetic control subjects (n = 16). Behavioral performance was assessed by percent correct responses. RESULTS During euglycemia, the WMT activated the bilateral frontal and parietal cortices, insula, thalamus, and cerebellum in both groups. During hypoglycemia, activation decreased in both groups but remained 80% larger in type 1 diabetic versus control subjects (P < 0.05). In type 1 diabetic subjects, higher HbA1c was associated with lower activation in the right parahippocampal gyrus and amygdala (R2 = 0.45, P < 0.002). Deactivation of the default-mode network (DMN) also was seen in both groups during euglycemia. However, during hypoglycemia, type 1 diabetic patients deactivated the DMN 70% less than control subjects (P < 0.05). Behavioral performance did not differ between glycemic conditions or groups. CONCLUSIONS BOLD activation was increased and deactivation was decreased in type 1 diabetic versus control subjects during hypoglycemia. This higher level of brain activation required by type 1 diabetic subjects to attain the same level of cognitive performance as control subjects suggests reduced cerebral efficiency in type 1 diabetes

A local-global problem for linear differential equations

An inhomogeneous linear differential equation Ly=f over a global differential field can have a formal solution for each place without having a global solution. The vector space lgl(L) measures this phenomenon. This space is interpreted in terms of cohomology of linear algebraic groups and is computed for abelian differential equations and for regular singular equations. An analogue of Artin reciprocity for abelian differential equations is given. Malgrange's work on irregularity is reproved in terms of cohomology of linear algebraic groups