Verification and validation of the high-performance Lorentz-Orbit Code for Use in Stellarators and Tokamaks (LOCUST)

| openaire: EC/H2020/633053/EU//EUROfusionA novel high-performance computing algorithm, developed in response to the next generation of computational challenges associated with burning plasma regimes in ITER-scale tokamak devices, has been tested and is described herein. The Lorentz-orbit code for use in stellarators and tokamaks (LOCUST) is designed for computationally scalable modelling of fast-ion dynamics, in the presence of detailed first wall geometries and fine 3D magnetic field structures. It achieves this through multiple levels of single instruction, multiple thread parallelism and by leveraging general-purpose graphics processing units. This enables LOCUST to rapidly track the full-orbit trajectories of kinetic Monte Carlo markers to deliver high-resolution fast-ion distribution functions and plasma-facing component power loads. LOCUST has been tested against the prominent NUBEAM and ASCOT fast-ion codes. All codes were compared for collisional plasmas in both high and low-aspect ratio toroidal geometries, with full-orbit and guiding-centre tracking. LOCUST produces statistically consistent results in line with acceptable theoretical and Monte Carlo uncertainties. Synthetic fast-ion D-α diagnostics produced by LOCUST are also compared to experiment using FIDASIM and show good agreement.Peer reviewe

No Cytotoxicity or Genotoxicity of Graphene and Graphene Oxide in Murine Lung Epithelial FE1 Cells in Vitro

International audienceGraphene and graphene oxide receive much attention these years, because they add attractive properties to a wide range of applications and products. Several studies have shown toxicological effects of other carbon-based nanomaterials such as carbon black nanoparticles and carbon nanotubes in vitro and in vivo. Here, we report in-depth physicochemical characterization of three commercial graphene materials, one graphene oxide (GO) and two reduced graphene oxides (rGO) and assess cytotoxicity and genotoxicity in the murine lung epithelial cell line FE1. The studied GO and rGO mainly consisted of 2-3 graphene layers with lateral sizes of 1-2 mu m. GO had almost equimolar content of C, O, and H while the two rGO materials had lower contents of oxygen with C/O and C/H ratios of 8 and 12.8, respectively. All materials had low levels of endotoxin and low levels of inorganic impurities, which were mainly sulphur, manganese, and silicon. GO generated more ROS than the two rGO materials, but none of the graphene materials influenced cytotoxicity in terms of cell viability and cell proliferation after 24 hr. Furthermore, no genotoxicity was observed using the alkaline comet assay following 3 or 24 hr of exposure. We demonstrate that chemically pure, few-layered GO and rGO with comparable lateral size (> 1 mu m) do not induce significant cytotoxicity or genotoxicity in FE1 cells at relatively high doses (5-200 mu g/ml). Environ. Mol. Mutagen. 57:469-482, 2016. (c) 2016 The Authors. Environmental and Molecular Mutagenesis Published by Wiley Periodicals, Inc