Colony and individual life-history responses to temperature in a social insect pollinator

Pollinating insects are of major ecological and commercial importance, yet they may be facing ecological disruption from a changing climate. Despite this threat, few studies have investigated the life-history responses of pollinators to experimentally controlled changes in temperature, which should be especially informative for species with complex life histories such as eusocial insects. This study uses the key pollinator Bombus terrestris, a eusocial bumble bee with an annual colony cycle, to determine how temperature affects life-history traits at both individual and colony levels. In two laboratory experiments, we reared B. terrestris colonies at either 20°C or 25°C, and measured differences in a set of life-history traits including colony longevity, queen longevity, worker longevity, production of workers, production of sexuals (queen and male production) and growth schedule, as well as effects on thermoregulatory behaviours. Higher rearing temperature had a significant positive effect on colony longevity in one of the two experiments but no significant effects on queen or worker longevity. Higher rearing temperature significantly increased colony size but did not affect the timing of peak colony size. It was also associated with significantly higher queen production but had no effect on the production of workers or males or the timing of male production. Higher temperature colonies exhibited significantly more wing-fanning by workers and significantly less wax canopy construction. Hence an increase in rearing temperature of a few degrees increased colony longevity, colony size and queen production. However, individual longevity was not affected and so may have been buffered by changes in costly thermoregulatory behaviours. We conclude that eusocial insects may show complex phenotypic responses to projected temperature increases under climate change, including effects on productivity and reproduction at the colony level. Such effects should be considered when predicting the impact of climate change on the provision of essential pollination services

Edge effects in game theoretic dynamics of spatially structured tumours

Background: Analysing tumour architecture for metastatic potential usually focuses on phenotypic differences due to cellular morphology or specific genetic mutations, but often ignore the cell's position within the heterogeneous substructure. Similar disregard for local neighborhood structure is common in mathematical models. Methods: We view the dynamics of disease progression as an evolutionary game between cellular phenotypes. A typical assumption in this modeling paradigm is that the probability of a given phenotypic strategy interacting with another depends exclusively on the abundance of those strategies without regard local heterogeneities. We address this limitation by using the Ohtsuki-Nowak transform to introduce spatial structure to the go vs. grow game. Results: We show that spatial structure can promote the invasive (go) strategy. By considering the change in neighbourhood size at a static boundary -- such as a blood-vessel, organ capsule, or basement membrane -- we show an edge effect that allows a tumour without invasive phenotypes in the bulk to have a polyclonal boundary with invasive cells. We present an example of this promotion of invasive (EMT positive) cells in a metastatic colony of prostate adenocarcinoma in bone marrow. Interpretation: Pathologic analyses that do not distinguish between cells in the bulk and cells at a static edge of a tumour can underestimate the number of invasive cells. We expect our approach to extend to other evolutionary game models where interaction neighborhoods change at fixed system boundaries.Comment: 14 pages, 3 figures; restructured abstract, added histology to fig. 1, added fig. 3, discussion of EMT introduced and cancer biology expande

Orbital selective and tunable Kondo effect of magnetic adatoms on graphene: Correlated electronic structure calculations

We have studied the effect of dynamical correlations on the electronic structure of single Co adatoms on graphene monolayers with a recently developed novel method for nanoscopic materials that combines density functional calculations with a fully dynamical treatment of the strongly interacting 3d-electrons. The coupling of the Co 3d-shell to the graphene substrate and hence the dynamic correlations are strongly dependent on the orbital symmetry and the system parameters (temperature, distance of the adatom from the graphene sheet, gate voltage). When the Kondo effect takes place, we find that the dynamical correlations give rise to strongly temperature-dependent peaks in the Co 3d-spectra near the Fermi level. Moreover, we find that the Kondo effect can be tuned by the application of a gate voltage. It turns out that the position of the Kondo peaks is pinned to the Dirac points of graphene rather than to the chemical potential.Comment: 12 pages, 7 figure

EXAMINING QUALITY INDICATOR RATES FOR OLDER HOME CARE CLIENTS WITH DUAL SENSORY IMPAIRMENT (DSI) AND EXPLORING THE HETEROGENEITY WITHIN DSI.

Older adults with impairments in both hearing and vision, called dual sensory impairment (DSI), are at an increased risk of negative health outcomes such as impaired communication and difficulties with mobility. It is unknown whether DSI is associated with potential quality of care issues. This study used a set of home care quality indicators (HCQIs) to examine potential quality issues in older clients (65+) with DSI. Further, it looked to explore how HCQI rates differed based on the geographic region of care and whether the client’s level of hearing and vision impairment was related to certain HCQIs. The HCQIs were generated from data collected using the Resident Assessment Instrument for Home Care and capture undesirable outcomes (e.g., falls, cognitive decline). Higher rates indicate a greater frequency of experiencing the issue. In this sample (n=352,656), the average age was 82.8 years (sd=7.9), the majority were female (63.2%), and 20.5% experienced DSI. Compared to those without DSI, clients with DSI had higher rates across 20 of the 22 HCQIs. The HCQI rates differed by geographic region, with specific regions consistently performing worse than others. Finally, the level of hearing and vision impairment was related to certain HCQIs more than others, for example hearing impairment appeared to be more related to the quality indicator measuring communication difficulty. Overall, the hope is that this information can help to identify some of the potential issues around quality and in turn, assist in continually improving the services being provided to these clients