Recovery-orientiertes Arbeiten im klinischen Kontext – stärkt das „Weddinger Modell“ die Selbstwirksamkeitserwartung und Resilienz?

Introduction Treatment of severe mental disorders aims not only at the reduction of symptoms but rather at the (re)establishment of personal wellbeing and social functioning, a process termed “recovery”. The concept of recovery comprises elements such as resilience and expected self-efficacy (ESE); it has been extensively studied in the USA, UK, Australia and Austria. This study employs the “Weddinger Modell” (WM), a comprehensive treatment concept particularly tailored to satisfy the needs of mentally ill inpatients in an urban area in Germany (Berlin) in terms of its impact on recovery. For that purpose, a specifically developed questionnaire (“Weddinger Resilienzfragebogen”) covering sociodemographic, biographic and disorder-related factors, was used to assess resilience, and another questionnaire (“Fragebogen zu Kompetenz- und Kontrollüberzeugungen“) to assess the expected self-efficacy. Furthermore, this explorative data collection explored the influence of sociodemographic factors on the ESE and analyzed the newly developed questionnaire regarding its structure and standards of quality. Methods We followed a naturalistic, quasi-experimental study design with surveys of two cohorts, cohort1 N=176 and cohort2 N=197, collected from a university department before and after the introduction of the “Weddinger Modell” and at the same time compared with control subjects recruited from external departments. The main analyses comprised a treatment group out of cohort2 N=83 tested by “Weddinger Resilienzfragebogen” and N=73 tested by “Fragebogen zu Kompetenz- und Kontrollüberzeugungen”. Results The treatment group showed no significant improvement neither with regard to resilience nor expected self-efficacy. The questionnaire testing resilience (“Weddinger Resilienz-fragebogen”) proved to be sufficient for construct validity. The explorative factor yielded only one factor. The educational status was identified as positively, in contrast suicidality negatively influencing the expected self-efficacy. Discussion This study, in contrast to earlier studies, failed to show effects of treatment interventions oriented to elements concerning recovery, here the “Weddinger Modell”, in particular resilience and expected self-efficacy, applied to severely mentally ill patients. This may be due to methodological problems. We found the cohorts and control groups to be inhomogeneous probably for further uncontrolled factors. Furthermore, the duration of this therapeutic intervention was probably too short to engender positive effects.Einleitung Die Behandlung von schweren psychischen Erkrankungen zielt nicht allein auf die Reduktion von Symptomen ab, sondern auch auf das (Wieder-) Erreichen persönlichen Wohlergehens und sozialer Teilhabe. Dieser Prozess wird „Recovery” genannt und umfasst Elemente der Resilienz und der Selbstwirksamkeitserwartung (SWE). Recovery wurde vor allem in den USA, Großbritannien, Australien und Österreich untersucht. Diese Studie untersucht das Behandlungskonzept „Weddinger Modell” (WM), welches speziell auf die Bedürfnisse von stationär behandelten psychisch Erkrankten im urbanen Raum in Berlin-Wedding (Deutschland) zugeschnitten ist, hinsichtlich seines Einflusses auf die SWE und Resilienz. Weitere Ziele der Studie waren die explorative Untersuchung von soziodemografischen Einflussfaktoren auf die SWE und die Untersuchung von Faktorenstruktur und Testgütekriterien des selbst entworfenen „Resilienzfragebogens“. Methoden Wir setzten ein naturalistisches, quasi-experimentelles, Studiendesign ein. Es wurden stationär behandelte Patienten in der Psychiatrischen Universitätsklinik der Charité im St. Hedwig Krankenhaus (PUK SHK) in zwei voneinander unabhängigen Kohorten vor und nach Einführung des WM untersucht. Hierzu wurden jeweils zeitgleich Kontrolluntersuchungen in Vergleichskrankenhäusern durchgeführt. Insgesamt wurden in Kohorte1 N=176 und in Kohorte2 N=197 Patienten eingeschlossen. Für die Hauptanalysen ergaben sich für die Interventionsgruppe in der PUK SHK Fallzahlen von N=83 (Resilienzfragebogen) und N=73 (Fragebogen zu Kompetenz- und Kontrollüberzeugungen). Ergebnisse Es konnte in der Interventionsgruppe keine signifikante Verbesserung – weder der Resilienz noch der SWE – gefunden werden. Der „Weddinger Resilienzfragebogen” wies eine gute Konstruktvalidität auf. Die explorative Faktorenanalyse ergab nur einen Faktor. Als positiver Einflussfaktor auf die SWE konnten der Bildungsstatus und als negativer Einfluss die Suizidalität exploriert werden. Diskussion Diese Studie konnte im Gegensatz zu früheren Studien keinen Effekt einer Behandlung nach Recovery-orientierten Modellen wie dem „Weddinger Modell” auf die beschriebenen Elemente von Recovery (Resilienz und Selbstwirksamkeitserwartung) bei stationär behandelten schwer psychisch Erkrankten zeigen. Ursachen könnten in der Methodik der Studie liegen. So lag eine Inhomogenität bezüglich der Kohorten und Vergleichsgruppen vor, die sich vermutlich auf weitere, nicht kontrollierte Faktoren erstreckt. Außerdem kamen möglicherweise positive Auswirkungen durch die kurze Dauer der therapeutischen Intervention des „Weddinger Modells” nicht zum Tragen

An Assessment of Customers Readiness, Loyalty and Satisfaction on E - Banking Services: A Nigerian Perspective

Despite the importance of electronic banking in many financial institutions, fewer studies have focused on customers’ satisfaction and customers readiness especially in an African setting. With the recent development in the information and technology world many customers have embraced e-banking. In this study, we measured the effect of customers’ readiness, loyalty and satisfaction on electronic banking services. We majorly used questionnaire that was designed on a 5-point scale to be able to collect good quantitative data. This study established that there is a significantly positive relationship between electronic banking readiness and customer’s satisfaction. The study recommended that more emphasis and efforts be laid on targeting individual clients, a more persuasive promotion of the e-banking should be conducted more regularly and banks should ensure nothing interrupts the flow of service delivery. In addition, electronic banking service providers ought to look out for indicators of innovative ways of creating awareness about the service through participation in trade organizations, exhibitions as well as adoption of new technologies on internet banking. Keywords: Internet banking, Information Technology, electronic banking adoption, end user satisfaction, fulfillmen

A clinical study to evaluate the combined effect of Yavaksharayukta Swarnamakshika with Varanadi Kashaya in benign prostatic hyperplasia

Benign Prostatic Hyperplasia (BPH) is the adenomatous hyperplasia of the periurethral part of the prostate gland that occurs especially in men over 50 years old and that tends to obstruct urination by constricting the urethra. Overall nearly 80% of men will develop BPH, and as many as 30% will receive treatment for it. The present study was a clinical validation and standardization of Ayurvedic medicines which can provide an improved response to the disease as the present conventional practices are not satisfactory. The study design was interventional. Twenty patients satisfying the selection criteria were selected from the OPD of Government Ayurveda College, Trivandrum. 125 mg of Swarnamakshika and Yavakshara were advised to take with Madhu, followed by 48 ml of Varanadikashaya for a period of 45 days. Assessments were done before and after the study using assessment criteria. The study was statistically significant in symptomatic relief. The study therefore concludes that the combination is effective in the management of BPH

Effect of Nano-Silica on the Physical, Mechanical and Thermal Properties of the Natural Rubber Latex Modified Concrete

452-457The preparation and properties of latex modified concrete (LMC), nano silica modified concrete (nSMC) and silica-latex modified concrete (SLMC) have been investigated in this study. Properties like compressive strength, tensile strength, flexural strength, thermal characteristics and water absorption have been evaluated. The 7-day compressive strength has increased 37% (30.15 N/mm2) after the inclusion of nano silica and latex. The composite has showed considerable improvements in splitting tensile strength (3.24 N/mm2), flexural strength (6.05 N/mm2) and thermal conductivity, while it lowered the water absorption rate. The property increase has been attributed to the pore filling and pozzolanic activity of nano silica and densification of matrix by natural rubber latex and nano silica. The results of this study have suggested that the addition of nano silica and latex could be a relevant technique toward conventional concrete as a key material along with energy efficient construction and building technology

Effect of Nano-Silica on the Physical, Mechanical and Thermal Properties of the Natural Rubber Latex Modified Concrete

The preparation and properties of latex modified concrete (LMC), nano silica modified concrete (nSMC) and silica-latex modified concrete (SLMC) have been investigated in this study. Properties like compressive strength, tensile strength, flexural strength, thermal characteristics and water absorption have been evaluated. The 7-day compressive strength has increased 37% (30.15 N/mm2) after the inclusion of nano silica and latex. The composite has showed considerable improvements in splitting tensile strength (3.24 N/mm2), flexural strength (6.05 N/mm2) and thermal conductivity, while it lowered the water absorption rate. The property increase has been attributed to the pore filling and pozzolanic activity of nano silica and densification of matrix by natural rubber latex and nano silica. The results of this study have suggested that the addition of nano silica and latex could be a relevant technique toward conventional concrete as a key material along with energy efficient construction and building technology

Canvass: a crowd-sourced, natural-product screening library for exploring biological space

NCATS thanks Dingyin Tao for assistance with compound characterization. This research was supported by the Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health (NIH). R.B.A. acknowledges support from NSF (CHE-1665145) and NIH (GM126221). M.K.B. acknowledges support from NIH (5R01GM110131). N.Z.B. thanks support from NIGMS, NIH (R01GM114061). J.K.C. acknowledges support from NSF (CHE-1665331). J.C. acknowledges support from the Fogarty International Center, NIH (TW009872). P.A.C. acknowledges support from the National Cancer Institute (NCI), NIH (R01 CA158275), and the NIH/National Institute of Aging (P01 AG012411). N.K.G. acknowledges support from NSF (CHE-1464898). B.C.G. thanks the support of NSF (RUI: 213569), the Camille and Henry Dreyfus Foundation, and the Arnold and Mabel Beckman Foundation. C.C.H. thanks the start-up funds from the Scripps Institution of Oceanography for support. J.N.J. acknowledges support from NIH (GM 063557, GM 084333). A.D.K. thanks the support from NCI, NIH (P01CA125066). D.G.I.K. acknowledges support from the National Center for Complementary and Integrative Health (1 R01 AT008088) and the Fogarty International Center, NIH (U01 TW00313), and gratefully acknowledges courtesies extended by the Government of Madagascar (Ministere des Eaux et Forets). O.K. thanks NIH (R01GM071779) for financial support. T.J.M. acknowledges support from NIH (GM116952). S.M. acknowledges support from NIH (DA045884-01, DA046487-01, AA026949-01), the Office of the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Medical Research Program (W81XWH-17-1-0256), and NCI, NIH, through a Cancer Center Support Grant (P30 CA008748). K.N.M. thanks the California Department of Food and Agriculture Pierce's Disease and Glassy Winged Sharpshooter Board for support. B.T.M. thanks Michael Mullowney for his contribution in the isolation, elucidation, and submission of the compounds in this work. P.N. acknowledges support from NIH (R01 GM111476). L.E.O. acknowledges support from NIH (R01-HL25854, R01-GM30859, R0-1-NS-12389). L.E.B., J.K.S., and J.A.P. thank the NIH (R35 GM-118173, R24 GM-111625) for research support. F.R. thanks the American Lebanese Syrian Associated Charities (ALSAC) for financial support. I.S. thanks the University of Oklahoma Startup funds for support. J.T.S. acknowledges support from ACS PRF (53767-ND1) and NSF (CHE-1414298), and thanks Drs. Kellan N. Lamb and Michael J. Di Maso for their synthetic contribution. B.S. acknowledges support from NIH (CA78747, CA106150, GM114353, GM115575). W.S. acknowledges support from NIGMS, NIH (R15GM116032, P30 GM103450), and thanks the University of Arkansas for startup funds and the Arkansas Biosciences Institute (ABI) for seed money. C.R.J.S. acknowledges support from NIH (R01GM121656). D.S.T. thanks the support of NIH (T32 CA062948-Gudas) and PhRMA Foundation to A.L.V., NIH (P41 GM076267) to D.S.T., and CCSG NIH (P30 CA008748) to C.B. Thompson. R.E.T. acknowledges support from NIGMS, NIH (GM129465). R.J.T. thanks the American Cancer Society (RSG-12-253-01-CDD) and NSF (CHE1361173) for support. D.A.V. thanks the Camille and Henry Dreyfus Foundation, the National Science Foundation (CHE-0353662, CHE-1005253, and CHE-1725142), the Beckman Foundation, the Sherman Fairchild Foundation, the John Stauffer Charitable Trust, and the Christian Scholars Foundation for support. J.W. acknowledges support from the American Cancer Society through the Research Scholar Grant (RSG-13-011-01-CDD). W.M.W.acknowledges support from NIGMS, NIH (GM119426), and NSF (CHE1755698). A.Z. acknowledges support from NSF (CHE-1463819). (Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health (NIH); CHE-1665145 - NSF; CHE-1665331 - NSF; CHE-1464898 - NSF; RUI: 213569 - NSF; CHE-1414298 - NSF; CHE1361173 - NSF; CHE1755698 - NSF; CHE-1463819 - NSF; GM126221 - NIH; 5R01GM110131 - NIH; GM 063557 - NIH; GM 084333 - NIH; R01GM071779 - NIH; GM116952 - NIH; DA045884-01 - NIH; DA046487-01 - NIH; AA026949-01 - NIH; R01 GM111476 - NIH; R01-HL25854 - NIH; R01-GM30859 - NIH; R0-1-NS-12389 - NIH; R35 GM-118173 - NIH; R24 GM-111625 - NIH; CA78747 - NIH; CA106150 - NIH; GM114353 - NIH; GM115575 - NIH; R01GM121656 - NIH; T32 CA062948-Gudas - NIH; P41 GM076267 - NIH; R01GM114061 - NIGMS, NIH; R15GM116032 - NIGMS, NIH; P30 GM103450 - NIGMS, NIH; GM129465 - NIGMS, NIH; GM119426 - NIGMS, NIH; TW009872 - Fogarty International Center, NIH; U01 TW00313 - Fogarty International Center, NIH; R01 CA158275 - National Cancer Institute (NCI), NIH; P01 AG012411 - NIH/National Institute of Aging; Camille and Henry Dreyfus Foundation; Arnold and Mabel Beckman Foundation; Scripps Institution of Oceanography; P01CA125066 - NCI, NIH; 1 R01 AT008088 - National Center for Complementary and Integrative Health; W81XWH-17-1-0256 - Office of the Assistant Secretary of Defense for Health Affairs through the Peer Reviewed Medical Research Program; P30 CA008748 - NCI, NIH, through a Cancer Center Support Grant; California Department of Food and Agriculture Pierce's Disease and Glassy Winged Sharpshooter Board; American Lebanese Syrian Associated Charities (ALSAC); University of Oklahoma Startup funds; 53767-ND1 - ACS PRF; PhRMA Foundation; P30 CA008748 - CCSG NIH; RSG-12-253-01-CDD - American Cancer Society; RSG-13-011-01-CDD - American Cancer Society; CHE-0353662 - National Science Foundation; CHE-1005253 - National Science Foundation; CHE-1725142 - National Science Foundation; Beckman Foundation; Sherman Fairchild Foundation; John Stauffer Charitable Trust; Christian Scholars Foundation)Published versionSupporting documentatio

Discovery of unconventional chiral charge order in kagome superconductor KV3Sb5

Intertwining quantum order and nontrivial topology is at the frontier of condensed matter physics. A charge density wave (CDW) like order with orbital currents has been proposed as a powerful resource for achieving the quantum anomalous Hall effect in topological materials and for the hidden phase in cuprate high-temperature superconductors. However, the experimental realization of such an order is challenging. Here we use high-resolution scanning tunnelling microscopy (STM) to discover an unconventional charge order in a kagome material KV3Sb5, with both a topological band structure and a superconducting ground state. Through both topography and spectroscopic imaging, we observe a robust 2x2 superlattice. Spectroscopically, an energy gap opens at the Fermi level, across which the 2x2 charge modulation exhibits an intensity reversal in real-space, signaling charge ordering. At impurity-pinning free region, the strength of intrinsic charge modulations further exhibits chiral anisotropy with unusual magnetic field response. Theoretical analysis of our experiments suggests a tantalizing unconventional chiral CDW in the frustrated kagome lattice, which can not only lead to large anomalous Hall effect with orbital magnetism, but also be a precursor of unconventional superconductivity.Comment: Orbital magnetism calculation adde

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or completely untested. To address this issue, the Canvass library of natural products was assembled, in collaboration with academic and industry researchers, for quantitative high-throughput screening (qHTS) across a diverse set of cell-based and biochemical assays. Characterization of the library in terms of physicochemical properties, structural diversity, and similarity to compounds in publicly available libraries indicates that the Canvass library contains many structural elements in common with approved drugs. The assay data generated were analyzed using a variety of quality control metrics, and the resultant assay profiles were explored using statistical methods, such as clustering and compound promiscuity analyses. Individual compounds were then sorted by structural class and activity profiles. Differential behavior based on these classifications, as well as noteworthy activities, are outlined herein. One such highlight is the activity of (−)-2(S)-cathafoline, which was found to stabilize calcium levels in the endoplasmic reticulum. The workflow described here illustrates a pilot effort to broadly survey the biological potential of natural products by utilizing the power of automation and high-throughput screening

The khmer software package: enabling efficient nucleotide sequence analysis

The khmer package is a freely available software library for working efficiently with fixed length DNA words, or k-mers. khmer provides implementations of a probabilistic k-mer counting data structure, a compressible De Bruijn graph representation, De Bruijn graph partitioning, and digital normalization. khmer is implemented in C++ and Python, and is freely available under the BSD license at https://github.com/dib-lab/khmer/