Provenance of invaders has scale-dependent impacts in a changing wetland ecosystem

Exotic species are associated with a variety of impacts on biodiversity, but it is unclear whether impacts of exotic species differ from those of native species with similar growth forms or native species invading disturbed sites. We compared presence and abundance of native and exotic invaders with changes in wetland plant species diversity over a 28-year period by re-surveying 22 ponds to identify factors correlated with observed changes. We also compared communities found within dense patches of native and exotic emergent species with similar habits. Within patches, we found no categorical diversity differences between areas dominated by native or exotic emergent species. At the pond scale, the cover of the exotic grass Phragmites australis best predicted change in diversity and evenness over time, likely owing to its significant increase in coverage over the study period. These changes in diversity and evenness were strongest in younger, less successionally-advanced ponds. Changes associated with cover of P. australis in these ponds were not consistent with expected diversity decreases, but instead with a dampening of diversity gains, such that the least-invaded ponds increased in diversity the most over the study period. There were more mixed effects on evenness, ranging from a reduction in evenness gains to actual losses of evenness in the ponds with highest invader cover. In this wetland complex, the habit, origin and invasiveness of species contribute to diversity responses in a scale- and context-dependent fashion. Future efforts to preserve diversity should focus on preventing the arrival and spread of invaders that have the potential to cover large areas at high densities, regardless of their origin. Future studies should also investigate more thoroughly how changes in diversity associated with species invasions are impacted by other ongoing ecosystem changes

The biological effects of subacute inhalation of diesel exhaust following addition of cerium oxide nanoparticles in atherosclerosis-prone mice

AbstractBackgroundCerium oxide (CeO2) nanoparticles improve the burning efficiency of fuel, however, little is known about health impacts of altered emissions from the vehicles.MethodsAtherosclerosis-prone apolipoprotein E knockout (ApoE−/−) mice were exposed by inhalation to diluted exhaust (1.7mg/m3, 20, 60 or 180min, 5 day/week, for 4 weeks), from an engine using standard diesel fuel (DE) or the same diesel fuel containing 9ppm cerium oxide nanoparticles (DCeE). Changes in hematological indices, clinical chemistry, atherosclerotic burden, tissue levels of inflammatory cytokines and pathology of the major organs were assessed.ResultsAddition of CeO2 to fuel resulted in a reduction of the number (30%) and surface area (10%) of the particles in the exhaust, whereas the gaseous co-pollutants were increased (6–8%). There was, however, a trend towards an increased size and complexity of the atherosclerotic plaques following DE exposure, which was not evident in the DCeE group. There were no clear signs of altered hematological or pathological changes induced by either treatment. However, levels of proinflammatory cytokines were modulated in a brain region and liver following DCeE exposure.ConclusionsThese results imply that addition of CeO2 nanoparticles to fuel decreases the number of particles in exhaust and may reduce atherosclerotic burden associated with exposure to standard diesel fuel. From the extensive assessment of biological parameters performed, the only concerning effect of cerium addition was a slightly raised level of cytokines in a region of the central nervous system. Overall, the use of cerium as a fuel additive may be a potentially useful way to limit the health effects of vehicle exhaust. However, further testing is required to ensure that such an approach is not associated with a chronic inflammatory response which may eventually cause long-term health effects

CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status

Human immunodeficiency virus (HIV) disease is associated with loss of CD4+ T cells, chronic immune activation, and progressive immune dysfunction. HIV-specific responses, particularly those of CD4+ T cells, become impaired early after infection, before the loss of responses directed against other antigens; the basis for this diminution has not been elucidated fully. The potential role of CD25+CD4+ regulatory T cells (T reg cells), previously shown to inhibit immune responses directed against numerous pathogens, as suppressors of HIV-specific T cell responses was investigated. In the majority of healthy HIV-infected individuals, CD25+CD4+ T cells significantly suppressed cellular proliferation and cytokine production by CD4+ and CD8+ T cells in response to HIV antigens/peptides in vitro; these effects were cell contact dependent and IL-10 and TGF-β independent. Individuals with strong HIV-specific CD25+ T reg cell function in vitro had significantly lower levels of plasma viremia and higher CD4+: CD8+ T cell ratios than did those individuals in whom this activity could not be detected. These in vitro data suggest that CD25+CD4+ T reg cells may contribute to the diminution of HIV-specific T cell immune responses in vivo in the early stages of HIV disease

Astigmatic correction with implantation of a light adjustable vs monofocal lens: a single site analysis of a randomized controlled trial

AIM To evaluate the light adjustable lens (LAL) vs a standard monofocal lens in achieving target astigmatic refraction and improving postoperative uncorrected distance visual acuity (UDVA). METHODS This randomized controlled clinical trial included 40 patients with pre-existing astigmatism and visually significant cataract. Twenty-eight patients received the LAL and 12 control patients received a monofocal intraocular lens (IOL) after cataract extraction at a single institution. The patients with the LAL underwent adjustment by ultraviolet (UV) light postoperatively plus subsequent lock-in procedures and all patients returned to clinic for follow up of study parameters at 6, 9, and 12mo. Manifest refraction, distance visual acuity, and adverse events were recorded at each visit. RESULTS The mean cylinder before adjustment in eyes with the LAL was -0.89±0.58 D (-2.00 to 0.00 D) and -0.34±0.34 D (-1.25 to 0.00 D) after lock-in (P=1.68x10−8). The mean cylinder in patients with the monofocal lens was -1.00±0.32 D (-1.50 to -0.50 D) at 17-21d postoperatively, which was statistically different from the LAL cylinder post lock-in (P=1.43x10−6). UDVA in the LAL group was 20/20 or better in 79% of patients post lock-in with good stability over 12mo compared with 33% of the control patients with UDVA of 20/20 or better. CONCLUSION These results demonstrate that the LAL is more effective in achieving target refractions and improving postoperative UDVA in patients with pre-existing corneal astigmatism than a standard monofocal lens

A fundamental relation between phase and group velocity, and application to the failure of perfectly matched layers in backward-wave structures

http://link.aps.org/doi/10.1103/PhysRevE.79.065601We demonstrate that the ratio of group to phase velocity has a simple relationship to the orientation of the electromagnetic field. In nondispersive materials, opposite group and phase velocity corresponds to fields that are mostly oriented in the propagation direction. More generally, this relationship (including the case of dispersive and negative-index materials) offers a perspective on the phenomena of backward waves and left-handed media. As an application of this relationship, we demonstrate and explain an irrecoverable failure of perfectly matched layer absorbing boundaries in computer simulations for constant cross-section waveguides with backward-wave modes and suggest an alternative in the form of adiabatic isotropic absorbers

Spark: A navigational paradigm for genomic data exploration

Biologists possess the detailed knowledge critical for extracting biological insight from genome-wide data resources, and yet they are increasingly faced with nontrivial computational analysis challenges posed by genome-scale methodologies. To lower this computational barrier, particularly in the early data exploration phases, we have developed an interactive pattern discovery and visualization approach, Spark, designed with epigenomic data in mind. Here we demonstrate Spark's ability to reveal both known and novel epigenetic signatures, including a previously unappreciated binding association between the YY1 transcription factor and the corepressor CTBP2 in human embryonic stem cells

Magnetospheres of Black Hole Systems in Force-Free Plasma

The interaction of black holes with ambient magnetic fields is important for a variety of highly energetic astrophysical phenomena. We study this interaction within the force-free approximation in which a tenuous plasma is assumed to have zero inertia. Blandford and Znajek (BZ) used this approach to demonstrate the conversion of some of the black hole's energy into electromagnetic Poynting flux in stationary and axisymmetric single black hole systems. We adopt this approach and extend it to examine asymmetric and, most importantly, dynamical systems by implementing the fully nonlinear field equations of general relativity coupled to Maxwell's equations. For single black holes, we study in particular the dependence of the Poynting flux and show that, even for misalignments between the black hole spin and the direction of the asymptotic magnetic field, a Poynting flux is generated with a luminosity dependent on such misalignment. For binary black hole systems, we show both in the head-on and orbiting cases that the moving black holes generate a Poynting flux.Comment: 13 pages, 11 figure

Pre-Impact Thermophysical Properties and the Yarkovsky Effect of NASA DART Target (65803) Didymos

The NASA DART (Double Asteroid Redirection Test) spacecraft impacted the secondary body of the binary asteroid (65803) Didymos on 2022 September 26and altered its orbit about the primary body. Before the DART impact, we performed visible and mid-infrared observations to constrain the pre-impact thermophysical properties of the Didymos system and to model its Yarkovsky effect. Analysis of the photometric phase curve derives a Bond albedo of 0.07 ± 0.01, and a thermophysical analysis of the mid-infrared observations derives a thermal inertia of 320 ± 70 J m-2 K-1 s-1/2 and a thermal roughness of 40° ± 3° RMS (root-mean-square) slope. These properties are compatible with the ranges derived for other S-type near-Earth asteroids. Model-to-measurement comparisons of the Yarkovsky orbital drift for Didymos derives a bulk density of 2750 ± 350 kg m-3, which agrees with other independent measures based on the binary mutual orbit. This bulk density indicates that Didymos is spinning at or near its critical spin-limit at which self-gravity balances equatorial centrifugal forces. Furthermore, comparisons with the post-impact infrared observations presented in Rivkin et al. (2023) indicate no change in the thermal inertia of the Didymos system following the DART impact. Finally, orbital temperature simulations indicate that sub-surface water ice is stable over geologic timescales in the polar regions if present. These findings will be investigated in more detail by the upcoming ESA Hera mission.<br/