Detecting Large Concept Extensions for Conceptual Analysis

When performing a conceptual analysis of a concept, philosophers are interested in all forms of expression of a concept in a text---be it direct or indirect, explicit or implicit. In this paper, we experiment with topic-based methods of automating the detection of concept expressions in order to facilitate philosophical conceptual analysis. We propose six methods based on LDA, and evaluate them on a new corpus of court decision that we had annotated by experts and non-experts. Our results indicate that these methods can yield important improvements over the keyword heuristic, which is often used as a concept detection heuristic in many contexts. While more work remains to be done, this indicates that detecting concepts through topics can serve as a general-purpose method for at least some forms of concept expression that are not captured using naive keyword approaches

Influence of Seabed Morphology and Substrate Composition On Mass-Transport Flow Processes and Pathways: Insights From the Magdalena Fan, Offshore Colombia

Although the effects of interactions between turbidity currents and the seabed have been widely studied, the roles of substrate and bathymetry on the emplacement of mass-transport complexes (MTCs) remain poorly constrained. This study investigates the effect of bathymetric variability and substrate heterogeneity on the distribution, morphology, and internal characteristics of nine MTCs imaged within a 3D seismic volume in the southern Magdalena Fan, offshore Colombia. The MTCs overlie substrate units composed mainly of channel–levee-complex sets, with subsidiary deposits of MTCs. MTC dispersal was influenced by tectonic relief, associated with a thin-skinned, deep-water fold-and-thrust belt, and by depositional relief, associated with the underlying channel–levee-complex sets; it was the former that exerted the first-order control on the location of mass-transport pathways. Channel–levee-complex sets channelized, diverted, or blocked mass flows, with the style of response largely controlled by their orientation with respect to the direction of the incoming flow and by the height of the levees with respect to flow thickness. MTC erosion can be relatively deep above channel-fill deposits, whereas more subtle erosional morphologies are observed above adjacent levee units. In the largest MTC, the distribution of the seismic facies is well imaged, being influenced by the underlying bathymetry, with internal horizontal contraction occurring updip of bathymetric highs, erosion and bypass predominating above higher gradient slopes, and increased disaggregation characterizing the margins. Hence, bathymetric irregularities and substrate heterogeneity together influence the pathways, geometries, and internal characteristics of MTCs, which could in turn influence flow rheology, runout distances, the presence and continuity of underlying reservoirs, and the capacity of MTCs to act as either hydrocarbon seals or reservoirs

Influence of Seabed Morphology and Substrate Composition On Mass-Transport Flow Processes and Pathways: Insights From the Magdalena Fan, Offshore Colombia

Although the effects of interactions between turbidity currents and the seabed have been widely studied, the roles of substrate and bathymetry on the emplacement of mass-transport complexes (MTCs) remain poorly constrained. This study investigates the effect of bathymetric variability and substrate heterogeneity on the distribution, morphology, and internal characteristics of nine MTCs imaged within a 3D seismic volume in the southern Magdalena Fan, offshore Colombia. The MTCs overlie substrate units composed mainly of channel–levee-complex sets, with subsidiary deposits of MTCs. MTC dispersal was influenced by tectonic relief, associated with a thin-skinned, deep-water fold-and-thrust belt, and by depositional relief, associated with the underlying channel–levee-complex sets; it was the former that exerted the first-order control on the location of mass-transport pathways. Channel–levee-complex sets channelized, diverted, or blocked mass flows, with the style of response largely controlled by their orientation with respect to the direction of the incoming flow and by the height of the levees with respect to flow thickness. MTC erosion can be relatively deep above channel-fill deposits, whereas more subtle erosional morphologies are observed above adjacent levee units. In the largest MTC, the distribution of the seismic facies is well imaged, being influenced by the underlying bathymetry, with internal horizontal contraction occurring updip of bathymetric highs, erosion and bypass predominating above higher gradient slopes, and increased disaggregation characterizing the margins. Hence, bathymetric irregularities and substrate heterogeneity together influence the pathways, geometries, and internal characteristics of MTCs, which could in turn influence flow rheology, runout distances, the presence and continuity of underlying reservoirs, and the capacity of MTCs to act as either hydrocarbon seals or reservoirs

iRFP is a real time marker for transformation based assays in high content screening

Anchorage independent growth is one of the hallmarks of oncogenic transformation. Here we show that infrared fluorescent protein (iRFP) based assays allow accurate and unbiased determination of colony formation and anchorage independent growth over time. This protocol is particularly compatible with high throughput systems, in contrast to traditional methods which are often labor-intensive, subjective to bias and do not allow further analysis using the same cells. Transformation in a single layer soft agar assay could be documented as early as 2 to 3 days in a 96 well format, which can be easily combined with standard transfection, infection and compound screening setups to allow for high throughput screening to identify therapeutic targets

Using the UM dynamical cores to reproduce idealised 3-D flows

This is the final version of the article. Available from the publisher via the DOI in this record.Published by Copernicus Publications on behalf of the European Geosciences UnionWe demonstrate that both the current (New Dynamics), and next generation (ENDGame) dynamical cores of the UK Met Office global circulation model, the UM, reproduce consistently, the long-term, large-scale flows found in several published idealised tests. The cases presented are the Held-Suarez test, a simplified model of Earth (including a stratosphere), and a hypothetical tidally locked Earth. Furthermore, we show that using simplifications to the dynamical equations, which are expected to be justified for the physical domains and flow regimes we have studied, and which are supported by the ENDGame dynamical core, also produces matching long-term, large-scale flows. Finally, we present evidence for differences in the detail of the planetary flows and circulations resulting from improvements in the ENDGame formulation over New Dynamics.We would like to thank Paul Ullrich and Kevin Heng for their valuable comments, when reviewing this manuscript. We would also like to thank Tom Melvin for his expert advice, and both Charline Marzin and Douglas Boyd for technical help. This work is supported by the European Research Council under the European Community’s Seventh Framework Programme (FP7/2007-2013 Grant Agreement no. 247060) and by the Consolidated STFC grant ST/J001627/1. This work is also partly supported by the Royal Society award WM090065. The calculations for this paper were performed on the DiRAC Facility jointly funded by STFC, the Large Facilities Capital Fund of BIS, and the University of Exeter

Contralateral manual compensation for velocity-dependent force perturbations

It is not yet clear how the temporal structure of a voluntary action is coded allowing coordinated bimanual responses. This study focuses on the adaptation to and compensation for a force profile presented to one stationary arm which is proportional to the velocity of the other moving arm. We hypothesised that subjects would exhibit predictive coordinative responses which would co-vary with the state of the moving arm. Our null hypothesis is that they develop a time-dependent template of forces appropriate to compensate for the imposed perturbation. Subjects were trained to make 500 ms duration reaching movements with their dominant right arm to a visual target. A force generated with a robotic arm that was proportional to the velocity of the moving arm and perpendicular to movement direction acted on their stationary left hand, either at the same time as the movement or delayed by 250 or 500 ms. Subjects rapidly learnt to minimise the final end-point error. In the delay conditions, the left hand moved in advance of the onset of the perturbing force. In test conditions with faster or slower movement of the right hand, the predictive actions of the left hand co-varied with movement speed. Compensation for movement-related forces appeared to be predictive but not based on an accurate force profile that was equal and opposite to the imposed perturbatio

Ready or not? Expectations of faculty and medical students for clinical skills preparation for clerkships

Background: Preclerkship clinical-skills training has received increasing attention as a foundational preparation for clerkships. Expectations among medical students and faculty regarding the clinical skills and level of skill mastery needed for starting clerkships are unknown. Medical students, faculty teaching in the preclinical setting, and clinical clerkship faculty may have differing expectations of students entering clerkships. If students' expectations differ from faculty expectations, students may experience anxiety. Alternately, congruent expectations among students and faculty may facilitate integrated and seamless student transitions to clerkships. Aims: To assess the congruence of expectations among preclerkship faculty, clerkship faculty, and medical students for the clinical skills and appropriate level of clinical-skills preparation needed to begin clerkships. Methods: Investigators surveyed preclinical faculty, clerkship faculty, and medical students early in their basic clerkships at a North American medical school that focuses on preclerkship clinical-skills development. Survey questions assessed expectations for the appropriate level of preparation in basic and advanced clinical skills for students entering clerkships. Results: Preclinical faculty and students had higher expectations than clerkship faculty for degree of preparation in most basic skills. Students had higher expectations than both faculty groups for advanced skills preparation. Conclusions: Preclinical faculty, clerkship faculty, and medical students appear to have different expectations of clinical-skills training needed for clerkships. As American medical schools increasingly introduce clinical-skills training prior to clerkships, more attention to alignment, communication, and integration between preclinical and clerkship faculty will be important to establish common curricular agendas and increase integration of student learning. Clarification of skills expectations may also alleviate student anxiety about clerkships and enhance their learning

Social relationship experiences of transgender people and their relational partners: A meta-synthesis

This is the final version. Available on open access from Elsevier via the DOI in this recordRationale: Social relationships are important in bolstering health and well-being for everyone in the general population. For transgender people, strong supportive social relationships may be paramount to their overall health and well-being due to their marginalised status in society. Objective: This review aimed to investigate what is currently known about social relationship experiences of transgender people and their relational partners (e.g., family members, romantic partners). Method: Thirty-nine qualitative papers were extracted from Web of Science, Scopus, Cochrane, and PubMed that related to social relationships of transgender people. These papers were analysed via a qualitative meta-synthesis. Results: Forty-nine second order themes were identified, initially organised into relational partner clusters (e.g., family, friends, work colleagues) for specific phenomena, then these were synthesized into five overarching conceptual themes: (1) Development of relationships through transition and beyond, (2) Coping strategies of transgender people and their relational partners, (3) Reciprocal support in social relationships, (4) Stigma enacted and ameliorated interpersonally, and (5) Influence of stigma on social health and well-being. Discussion and conclusions: These overarching themes show the potential characteristics that assist in the health-buffering role of social relationships for transgender people and their relational partners. Of particular note, stigma was reported as a common negative experience by transgender people and their relational partners, and open communicative social relationships had positive effects on self-conceptualisations of identity, which were inferred to protect against the damaging effects of stigma. We discuss the various implications and applications of this meta-synthesis to future research and clinical settings as well as how it can inform healthcare policy to support transgender people.Devon Partnership NHS Trus

Pathological Features of Breast Cancer seen in Northwestern Tanzania: A Nine Years Retrospective Study.

Breast cancer is more common in Western Countries compared to African populations. However in African population, it appears that the disease tends to be more aggressive and occurring at a relatively young age at the time of presentation. The aim of this study was to describe the trend of Breast Cancer in Northwestern Tanzania. This was a retrospective study which involved all cases of breast cancer diagnosed histologically at Bugando Medical Center from 2002 to 2010. Histological results and slides were retrieved from the records in the Pathology department, clinical information and demographic data for patients were retrieved from surgical wards and department of medical records. Histology slides were re-evaluated for the histological type, grade (By modified Bloom-Richardson score), and presence of necrosis and skin involvement. Data was entered and analyzed by SPSS computer software version 15. There were 328 patients histologically confirmed to have breast cancer, the mean age at diagnosis was 48.7 years (+/- 13.1). About half of the patients (52.4%) were below 46 years of age, and this group of patients had significantly higher tendency for lymph node metastasis (p = 0.012). The tumor size ranged from 1 cm to 18 cm in diameter with average (mean) of 5.5 cm (+/- 2.5), and median size of 6 cm. Size of the tumor (above 6 cm in diameter) and presence of necrosis within the tumor was significantly associated with high rate of lymph node metastasis (p = 0.000). Of all patients, 64% were at clinical stage III (specifically IIIB) and 70.4% had lymph node metastasis at the time of diagnosis. Only 4.3% of the patients were in clinical stage I at the time of diagnosis. Majority of the patients had invasive ductal carcinoma (91.5%) followed by mucinous carcinoma (5.2%), Invasive lobular carcinoma (3%) and in situ ductal carcinoma (0.3%). In all patients, 185 (56.4%) had tumor with histological grade 3. Breast cancer in this region show a trend towards relative young age at diagnosis with advanced stage at diagnosis and high rate of lymph node metastasis. Poor Referral system, lack of screening programs and natural aggressive biological behavior of tumor may contribute to advanced disease at the time of diagnosis

Systematic variation in food web body-size structure linked to external subsidies.

The relationship between body mass (M) and size class abundance (N) depicts patterns of community structure and energy flow through food webs. While the general assumption is that M and N scale linearly (on log-log axes), nonlinearity is regularly observed in natural systems, and is theorized to be driven by nonlinear scaling of trophic level (TL) with M resulting in the rapid transfer of energy to consumers in certain size classes. We tested this hypothesis with data from 31 stream food webs. We predicted that allochthonous subsidies higher in the web results in nonlinear M-TL relationships and systematic abundance peaks in macroinvertebrate and fish size classes (latter containing salmonids), that exploit terrestrial plant material and terrestrial invertebrates, respectively. Indeed, both M-N and M-TL significantly deviated from linear relationships and the observed curvature in M-TL scaling was inversely related to that observed in M-N relationships. Systemic peaks in M-N, and troughs in M-TL occurred in size classes dominated by generalist invertebrates, and brown trout. Our study reveals how allochthonous resources entering high in the web systematically shape community size structure and demonstrates the relevance of a generalized metabolic scaling model for understanding patterns of energy transfer in energetically 'open' food webs