Characterizing droplet combustion of pure and multi-component liquid fuels in a microgravity environment

The importance of understanding the effects of fuel composition, length scales, and other parameters on the combustion of liquid fuels has motivated the examination of simple flames which have easily characterized flow fields and hence, the potential of being modeled accurately. One such flame for liquid fuel combustion is the spherically symmetric droplet flame which can be achieved in an environment with sufficiently low gravity (i.e., low buoyancy). To examine fundamental characteristics of spherically symmetric droplet combustion, a drop tower facility has been employed to provide a microgravity environment to study droplet combustion. This paper gives a brief review of results obtained over the past three years under NASA sponsorship (grant NAG3-987)

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease

Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown. We hypothesized that the transcriptional regulator of the stress response, heat shock factor 1 (HSF1), would play an important role in prion disease. Uninoculated HSF1 knockout (KO) mice used in our study do not show signs of neurodegeneration as assessed by survival, motor performance, or histopathology. When inoculated with Rocky Mountain Laboratory (RML) prions HSF1 KO mice had a dramatically shortened lifespan, succumbing to disease ≈20% faster than controls. Surprisingly, both the onset of home-cage behavioral symptoms and pathological alterations occurred at a similar time in HSF1 KO and control mice. The accumulation of proteinase K (PK)-resistant PrP also occurred with similar kinetics and prion infectivity accrued at an equal or slower rate. Thus, HSF1 provides an important protective function that is specifically manifest after the onset of behavioral symptoms of prion disease

Hydrogenation of alkynyl substituted aromatics over rhodium/silica

The cascade reactions of phenylacetylene to ethylcyclohexane and 1-phenyl-1-propyne to propylcyclohexane were studied individually, under deuterium and competitively at 343 K and 3 barg pressure over a Rh/silica catalyst. Both systems gave similar activation energies for alkyne hydrogenation (56 ± 4 kJ mol−1 for phenylacetylene and 50 ± 4 kJ mol−1 for 1-phenyl-1-propyne). Over fresh catalyst the order of reactivity was styrene > phenylacetylene ≫ ethylbenzene. Whereas with the cascade hydrogenation starting with phenylacetylene, styrene hydrogenated much slower phenylacetylene even once all the phenylacetylene was hydrogenated. The activity of ethylbenzene was also reduced in the cascade reaction and after styrene hydrogenation. These reductions in rate were likely due to carbon laydown from phenylacetylene and styrene. Similar behavior was observed with the 1-phenyl-1-propyne cascade. Deuterium experiments revealed similar positive KIEs for phenylacetylene (2.6) and 1-phenyl-1-propyne (2.1). Ethylbenzene hydrogenation/deuteration gave a KIE of 1.6 obtained after styrene hydrogenation in contrast to the inverse KIE of 0.4 found with ethylbenzene hydrogenation/deuteration over a fresh catalyst, indicating a change in rate determining step. Competitive hydrogenation between phenylacetylene and styrene reduced the rate of phenylacetylene hydrogenation but increased selectivity to ethylbenzene suggesting a change in the flux of sub-surface hydrogen. In the competitive reaction between 1-phenyl-1-propyne and propylbenzene, the rate of hydrogenation of 1-phenyl-1-propyne was increased and the rate of alkene isomerization was decreased, likely due to an increase in the hydrogen flux for hydrogenation and a decrease in the hydrogen species active in methylstyrene isomerization

General practice pharmacists in Australia:A systematic review

BACKGROUND: The inclusion of pharmacists into general practices in Australia has expanded in recent years. This systematic review aimed to synthesise the literature of qualitative and quantitative studies, and identify the knowledge gaps, related to pharmacists working in general practice in Australia. METHODS: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, EBSCOhost, EMBASE, and the Cochrane Library were searched from the inception of databases to January 2021. The search was focused on studies investigating general practice pharmacists in Australia. The quality of each study was appraised using the Mixed Method Appraisal Tool criteria. The narrative synthesis approach was utilised to describe data due to the heterogeneity among study designs and measures. RESULTS: Twenty-five studies were included in this review. General practice pharmacists engaged in various non-dispensing patient care services, with medication management reviews being the primary activity reported. General practice pharmacists’ characteristics and an environment with a willingness of collaboration were the notable influencing factors for successfully including pharmacists in general practices. Factors that posed a challenge to the adoption of general practice pharmacists were lack of funding and other resources, poorly defined roles, and absence of mentoring/training. CONCLUSION: This review has summarised the characteristics, activities, benefits, barriers, and facilitators of including pharmacists in general practices in Australia. General practice pharmacists are well accepted by stakeholders, and they can engage in a range of patient-centred activities to benefit patients. There is a need for more robust research to explore the patient and economic outcomes related to clinical activities that a pharmacist can perform in general practice, as a foundation to developing an appropriate and sustainable funding model. The findings of this review will be beneficial for pharmacists, researchers, policymakers, and readers who wish to implement the role of general practice pharmacists in the future

Strongly Anisotropic Magnesiowüstite in Earth's Lower Mantle

The juxtaposition of a liquid iron‐dominant alloy against a mixture of silicate and oxide minerals at Earth's core‐mantle boundary is associated with a wide range of complex seismological features. One category of observed structures is ultralow‐velocity zones, which are thought to correspond to either aggregates of partially molten material or solid, iron‐enriched assemblages. We measured the phonon dispersion relations of (Mg,Fe) O magnesiowüstite containing 76 mol % FeO, a candidate ultralow‐velocity zone phase, at high pressures using high‐energy resolution inelastic X‐ray scattering. From these measurements, we find that magnesiowüstite becomes strongly elastically anisotropic with increasing pressure, potentially contributing to a significant proportion of seismic anisotropy detected near the base of the mantle

Mechanisms Controlling the Degradation of Poly (methyl methacrylate) Prior to Piloted Ignition

Research paper presented at the International Combustion Symposium 2002 and published by in the Proceedings of the Combustion Institute.Degradation of Type-G PMMA (Rohm and Haas) plates was studied prior to piloted ignition. The onset of pyrolysis was estimated by means of an infrared camera with an MMA filter, a small load cell, thermocouples, and flow visualization. Onset of gasification due to material pyrolysis occurs significantly earlier than piloted ignition. Therefore, models of standard test methods such as ASTM-E-1321 must incorporate pre-ignition gasification to properly model the ignition process. To better establish the mechanisms controlling the degradation process, controlled mass loss tests were conducted with shavings from the PMMA plates. Tests in nitrogen and oxygenated atmospheres were conducted with thermogravimetric analysis and evolved gas measurements using a quadrupole mass spectrometer. Results indicated a one step degradation process in pure N while a two-step reaction could be observed in the presence of O2 . As O2 fraction increased, the onset of degradation shifted to lower temperatures but the second step correlated well with that of N2 degradation. The evolved gas measurements suggest that both reactions were limited by mass transport, with the first reaction limited by O2 diffusion into the sample. Mass transport limitations were identified by abrupt changes in the slope of production rate of evolved gases, and this indicates the importance of coupling TGA measurements with evolved gas analysis for detecting mass transport limitations. Implications of these results on interpreting material flammability tests are discussed in this paper

Ariel - Volume 4 Number 6

Editors David A. Jacoby Eugenia Miller Tom Williams Associate Editors Paul Bialas Terry Burt Michael Leo Gail Tenikat Editor Emeritus and Business Manager Richard J. Bonnano Movie Editor Robert Breckenridge Staff Richard Blutstein Mary F. Buechler J.D. Kanofsky Rocket Weber David Maye

Casimir-Polder interaction between an atom and a small magnetodielectric sphere

On the basis of macroscopic quantum electrodynamics and point-scattering techniques, we derive a closed expression for the Casimir-Polder force between a ground-state atom and a small magnetodielectric sphere in an arbitrary environment. In order to allow for the presence of both bodies and media, local-field corrections are taken into account. Our results are compared with the known van der Waals force between two ground-state atoms. To continuously interpolate between the two extreme cases of a single atom and a macroscopic sphere, we also derive the force between an atom and a sphere of variable radius that is embedded in an Onsager local-field cavity. Numerical examples illustrate the theory.Comment: 9 pages, 4 figures, minor addition

Cholesterol Alters the Orientation and Activity of the Influenza Virus M2 Amphipathic Helix in the Membrane

The influenza virus M2 amphipathic helix (M2AH) alters membrane curvature in a cholesterol-dependent manner, mediating viral membrane scission during influenza virus budding. Here, we have investigated the biophysical effects of cholesterol on the ability of an M2AH peptide to manipulate membrane properties. We see that the ability of the M2AH to interact with membranes and form an α-helix is independent of membrane cholesterol concentration; however, cholesterol affects the angle of the M2AH peptide within the membrane. This change in membrane orientation affects the ability of the M2AH to alter lipid order. In lowcholesterol membranes, the M2AH is inserted near the level of the lipid head groups, increasing lipid order, which may contribute to generation of the membrane curvature. As the cholesterol content increases, the M2AH insertion becomes flatter and slightly deeper in the membrane below the lipid headgroups, where the polar face can continue to interact with the headgroups while the hydrophobic face binds cholesterol. This changed orientation minimizes lipid packing defects and lipid order changes, likely reducing the generation of membrane curvature. Thus, cholesterol regulates M2 membrane scission by precisely modulating M2AH positioning within the membrane. This has implications for the understanding of many of amphipathic-helix-driven cellular budding processes that occur in specific lipid environments

High Frequency Peakers: young radio sources or flaring blazars?

We present new, simultaneous, multifrequency observations of 45 out of the 55 candidate High Frequency Peakers (HFP) selected by Dallacasa et al. (2000), carried out 3 to 4 years after a first set of observations. Our sub-sample consists of 10 galaxies, 28 stellar objects (``quasars'') and 7 unidentified sources. Both sets of observations are sensitive enough to allow the detection of variability at the 10% level or lower. While galaxies do not show significant variability, most quasars do. Seven of them no longer show the convex spectrum which is the defining property of Gigahertz Peaked Spectrum (GPS)/HFP sources and are interpreted as blazars caught by Dallacasa et al. (2000) during a flare, when a highly self-absorbed component dominated the emission. In general, the variability properties (amplitude, timescales, correlation between peak luminosity and peak frequency of the flaring component) of the quasar sub-sample resemble those of blazars. We thus conclude that most HFP candidates identified with quasars may well be flaring blazars.Comment: 20 pages, 18 figures, accepted for publication in Astronomy & Astrophysic