Production scheduling with fixed lot sizes and constrained total capacity

A heuristic model is developed for obtaining the monthly production schedule in a multiproduct shop with a constraint on aggregate capacity

An X-ray absorption spectroscopic study at the mercury LIII edge on phenylmercury(II) oxygen species

The X-ray absorption spectra of the reference and model compounds HgCl2, PhHgCl, PhHgOAc and [(PhHg)2OH][BF4].H2O have been analysed in both the XANES and EXAFS regions, and the technique was extended to determine the structures of (PhHg)2O, PhHgOH, and the basic salts PhHgOH.PhHgNO3 and PhHgOH.(PhHg)2SO4, which were previously structurally uncharacterised. Results indicate that (PhHg)2O is a molecular species with Hg-O-Hg 135°, while PhHgOH contains the [(PhHg)2OH]+ cation and is better formulated as [(PhHg)2OH]OH. The same cation is also featured in the two basic salts. Electrospray mass spectral studies of PhHgOH in aqueous solutions show that [PhHgOH2]+, [(PhHg)2OH]+ and [(PhHg)3O]+ co-exist in solution in a pH-dependent equilibrium

A Spatially Distributed Energy Balance Snowmelt Model

This paper describes an energy balance snowmelt model developed for the prediction of rapid snowmelt rates responsible for soil erosion and water input to a distributed water balance model. The model uses a lumped representation of the snowpack with two state variables, namely, water equivalent and energy content relative to a reference state of water in the ice phase at 0 degrees Celcius. This energy content is used to determine snowpack average temperature of liquid fraction. This representation of the snowpack is used to determine snowpack average temperature of liquid fraction. This representation of the snowpack is used in a distributed version of the model with each of these state variables modeled at each point on a rectangular grid corresponding to a digital elevation model. Inputs are air temperature, precipitation, wind speed, humidity and radiation at hourly time steps. The model uses physically based calculations of radiative, sensible, latent and advective heat exchanges. An equilibrium parameterization of snow surface temperature accounts for differences between snow surface temperature and average snowpack temperature without having to introduce additional state variables. Melt outlfow is a function of the liquid fraction, using Darcy\u27s law. This allows the model to account for continued outlflow even when the energy balance is negative. A detailed description of the model is given together with results of tests of individual components and the complete model against data collected at the Central Sierra Snow Laboratory, California; Reynolds Creek Experimental Watershed, Boise Idaho; and at the Utah State University drainage research farm, Logan Utah. The testing includes comparisons against melt outflow collected in lysimeters and melt collectors, surface snow temperatures collected using infrared temperature sensors and depth and water equivalent measured using snow core samplers

Representing Structural Information of Helical Charge Distributions in Cylindrical Coordinates

Structural information in the local electric field produced by helical charge distributions, such as dissolved DNA, is revealed in a straightforward manner employing cylindrical coordinates. Comparison of structure factors derived in terms of cylindrical and helical coordinates is made. A simple coordinate transformation serves to relate the Green function in cylindrical and helical coordinates. We also compare the electric field on the central axis of a single helix as calculated in both systems.Comment: 11 pages in plain LaTex, no figures. Accepted for publication in PRE March, 199

Reformulation initiative for partial replacement of saturated with unsaturated fats in dairy foods attenuates the increase in LDL cholesterol and improves flow-mediated dilatation compared with conventional dairy: the randomized, controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) study

Background Modifying dairy fat composition by increasing the MUFA content is a potential strategy to reduce dietary SFA intake for cardiovascular disease (CVD) prevention in the population. Objectives To determine the effects of consuming SFA-reduced, MUFA-enriched (modified) dairy products, compared with conventional dairy products (control), on the fasting cholesterol profile (primary outcome), endothelial function assessed by flow-mediated dilatation (FMD; key secondary outcome), and other cardiometabolic risk markers. Methods A double-blind, randomized, controlled crossover 12-wk intervention was conducted. Participants with a 1.5-fold higher (moderate) CVD risk than the population mean replaced habitual dairy products with study products (milk, cheese, and butter) to achieve a high-fat, high-dairy isoenergetic daily dietary exchange [38% of total energy intake (%TE) from fat: control (dietary target: 19%TE SFA; 11%TE MUFA) and modified (16%TE SFA; 14%TE MUFA) diet]. Results Fifty-four participants (57.4% men; mean ± SEM age: 52 ± 3 y; BMI: 25.8 ± 0.5 kg/m2) completed the study. The modified diet attenuated the rise in fasting LDL cholesterol observed with the control diet (0.03 ± 0.06 mmol/L and 0.19 ± 0.05 mmol/L, respectively; P = 0.03). Relative to baseline, the %FMD response increased after the modified diet (0.35% ± 0.15%), whereas a decrease was observed after the control diet (−0.51% ± 0.15%; P< 0.0001). In addition, fasting plasma nitrite concentrations increased after the modified diet, yet decreased after the control diet (0.02 ± 0.01 μmol/L and −0.03 ± 0.02 μmol/L, respectively; P = 0.01). Conclusions In adults at moderate CVD risk, consumption of a high-fat diet containing SFA-reduced, MUFA-enriched dairy products for 12 wk showed beneficial effects on fasting LDL cholesterol and endothelial function compared with conventional dairy products. Our findings indicate that fatty acid modification of dairy products may have potential as a public health strategy aimed at CVD risk reduction. This trial was registered at clinicaltrials.gov as NCT02089035

New Method to Calculate Electrical Forces Acting on a Sphere in an Electrorheological Fluid

We describe a method to calculate the electrical force acting on a sphere in a suspension of dielectric spheres in a host with a different dielectric constant, under the assumption that a spatially uniform electric field is applied. The method uses a spectral representation for the total electrostatic energy of the composite. The force is expressed as a certain gradient of this energy, which can be expressed in a closed analytic form rather than evaluated as a numerical derivative. The method is applicable even when both the spheres and the host have frequency-dependent dielectric functions and nonzero conductivities, provided the system is in the quasistatic regime. In principle, it includes all multipolar contributions to the force, and it can be used to calculate multi-body as well as pairwise forces. We also present several numerical examples, including host fluids with finite conductivities. The force between spheres approaches the dipole-dipole limit, as expected, at large separations, but departs drastically from that limit when the spheres are nearly in contact. The force may also change sign as a function of frequency when the host is a slightly conducting fluid.Comment: 29 pages, 8 figures, Accepted for Publication in Physical Review

Cherenkov Radiation from e+e−e^+e^- Pairs and Its Effect on νe\nu_e Induced Showers

We calculate the Cherenkov radiation from an $e^+e^-$ pair at small separations, as occurs shortly after a pair conversion. The radiation is reduced (compared to that from two independent particles) when the pair separation is smaller than the wavelength of the emitted light. We estimate the reduction in light in large electromagnetic showers, and discuss the implications for detectors that observe Cherenkov radiation from showers in the Earth's atmosphere, as well as in oceans and Antarctic ice.Comment: Final version, with minor changes, to appear in PRD. 5 pages with 4 figure

Exposure to Nickel, Chromium, or Cadmium Causes Distinct Changes in the Gene Expression Patterns of a Rat Liver Derived Cell Line

Many heavy metals, including nickel (Ni), cadmium (Cd), and chromium (Cr) are toxic industrial chemicals with an exposure risk in both occupational and environmental settings that may cause harmful outcomes. While these substances are known to produce adverse health effects leading to disease or health problems, the detailed mechanisms remain unclear. To elucidate the processes involved in the toxicity of nickel, cadmium, and chromium at the molecular level and to perform a comparative analysis, H4-II-E-C3 rat liver-derived cell lines were treated with soluble salts of each metal using concentrations derived from viability assays, and gene expression patterns were determined with DNA microarrays. We identified both common and unique biological responses to exposure to the three metals. Nickel, cadmium, chromium all induced oxidative stress with both similar and unique genes and pathways responding to this stress. Although all three metals are known to be genotoxic, evidence for DNA damage in our study only exists in response to chromium. Nickel induced a hypoxic response as well as inducing genes involved in chromatin structure, perhaps by replacing iron in key proteins. Cadmium distinctly perturbed genes related to endoplasmic reticulum stress and invoked the unfolded protein response leading to apoptosis. With these studies, we have completed the first gene expression comparative analysis of nickel, cadmium, and chromium in H4-II-E-C3 cells